Dependence and reduced motor function in heart failure: future directions for well-being

Hibino, Hidetaka; Gorniak, Stacey L.

doi:10.1007/s10741-021-10145-2

Cited by 2 publications

(1 citation statement)

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“…As such, it is not surprising that HF is associated with poor HRQOL, given that patients with HF present with a cluster of incapacitating symptoms ranging from physical signs and symptoms (dyspnea, orthopnea, bendopnea, nocturnal cough, fatigue, exercise intolerance, palpitations, dizziness, bloating, peripheral edema, ascites, pain, cachexia) to psychological, emotional and mental manifestations (confusion, depression, anxiety, sleep disorders, cognitive impairment) [1,[10][11][12]. These symptoms, either individually or collectively and oftentimes in conjunction with adverse effects from HF treatment per se, interfere with activities of daily living, limit functional performance and disrupt multiple domains of life, ultimately impairing patient's well-being and HRQOL and rendering the patient dependent on caregivers, while leading to social isolation, anxiety and depression [13][14][15][16][17][18][19]. Of note, HRQOL seems to be impaired even in the early asymptomatic phases of HF and continues to deteriorate as HF gradually becomes more overt [20].…”

Section: Introductionmentioning

confidence: 99%

Differences in Health-Related Quality of Life among Patients with Heart Failure

Ventoulis,

Kamperidis,

Abraham

et al. 2024

Medicina

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Heart failure (HF) is characterized by a progressive clinical course marked by frequent exacerbations and repeated hospitalizations, leading to considerably high morbidity and mortality rates. Patients with HF present with a constellation of bothersome symptoms, which range from physical to psychological and mental manifestations. With the transition to more advanced HF stages, symptoms become increasingly more debilitating, interfere with activities of daily living and disrupt multiple domains of life, including physical functioning, psychological status, emotional state, cognitive function, intimate relationships, lifestyle status, usual role activities, social contact and support. By inflicting profuse limitations in numerous aspects of life, HF exerts a profoundly negative impact on health-related quality of life (HRQOL). It is therefore not surprising that patients with HF display lower levels of HRQOL compared not only to the general healthy population but also to patients suffering from other chronic diseases. On top of this, poor HRQOL in patients with HF becomes an even greater concern considering that it has been associated with unfavorable long-term outcomes and poor prognosis. Nevertheless, HRQOL may differ significantly among patients with HF. Indeed, it has consistently been reported that women with HF display poorer HRQOL compared to men, while younger patients with HF tend to exhibit lower levels of HRQOL than their older counterparts. Moreover, patients presenting with higher New York Heart Association (NYHA) functional class (III–IV) have significantly more impaired HRQOL than those in a better NYHA class (I–II). Furthermore, most studies report worse levels of HRQOL in patients suffering from HF with preserved ejection fraction (HFpEF) compared to patients with HF with reduced ejection fraction (HFrEF) or HF with mildly reduced ejection fraction (HFmrEF). Last, but not least, differences in HRQOL have been noted depending on geographic location, with lower HRQOL levels having been recorded in Africa and Eastern Europe and higher in Western Europe in a recent large global study. Based on the observed disparities that have been invariably reported in the literature, this review article aims to provide insight into the underlying differences in HRQOL among patients with HF. Through an overview of currently existing evidence, fundamental differences in HRQOL among patients with HF are analyzed based on sex, age, NYHA functional class, ejection fraction and geographic location or ethnicity.

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