Deoxyribonucleic Acid Synthesis in Oocytes of Mouse Embryos

Peters, Hannah; Levy, Emilia; Crone, Monna

doi:10.1038/195915a0

Cited by 67 publications

(30 citation statements)

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“…No labelled germ cells were found in the ovaries of animals injected with tritiated thymidine after the end of day 4 p.p., the labelling of these ovaries being restricted to the follicular cells (Fig. 19), as occurs in the comparable period in the mouse (Peters et al, 1962) and the rabbit (Peters et a!., 1965).…”

Section: Resultsmentioning

confidence: 99%

“…S w if t (1950) reported that in mouse spermatocytes DNA synthesis occurs during the last premeiotic interphase, i.e., the interval between the last mitotic division and the beginning of meiosis. Peters et al (1962) showed that DNA synthesis in the female germ cells of the mouse is a fairly synchronised process restricted, largely, to three days during foetal life. These three days, vi%., 13th, 14th and 15th postcoitum, coincide with the time at which most of the germ cells enter the first meiotic prophase (B orum, 1961).…”

Section: Introductionmentioning

confidence: 99%

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Oogenesis in the golden hamster (<i>Mesocricetus auratus</i>)

Lemon

Morton

1968

Cytogenet Genome Res

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A study was made of the first meiotic prophase in the female germ cells of the golden hamster (Mesocricetus auratus). It was found to commence immediately after birth, and all the germ cells had entered the diplotene stage by day 9 postpartum. The period during which the germ cells synthesised DNA was determined using an autoradiographic technique, and was found to be restricted to the first four days after birth.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oogenesis in the golden hamster (<i>Mesocricetus auratus</i>)

Lemon

Morton

1968

Cytogenet Genome Res

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“…the order in which oocytes ovulate postnatally follows the order in which oogonia entered meiosis (and cannot re-enter mitosis) in the embryonic ovary. Meiotic entry is not an 'all-or-none' event but a gradual process occurring from e13.5 to e18.5 (Peters et al 1962, Ghafari et al 2007) and progressing in the ovary in a cranialcaudal direction (Bullejos & Koopman 2004). Many oogonia in the fetal mouse (and human) ovary continue mitosis while others enter meiotic prophase (Evans 1982, Fulton et al 2005) and therefore oogonia with fewer or greater numbers of mitotic divisions would respectively transit early or later into meiosis.…”

Section: The Primordial Follicle Reserve: Is It Renewable?mentioning

confidence: 99%

The dynamics of the primordial follicle reserve

Kerr¹,

Myers²,

Anderson³

2013

Reproduction

137

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The female germline comprises a reserve population of primordial (non-growing) follicles containing diplotene oocytes arrested in the first meiotic prophase. By convention, the reserve is established when all individual oocytes are enclosed by granulosa cells. This commonly occurs prior to or around birth, according to species. Histologically, the 'reserve' is the number of primordial follicles in the ovary at any given age and is ultimately depleted by degeneration and progression through folliculogenesis until exhausted. How and when the reserve reaches its peak number of follicles is determined by ovarian morphogenesis and germ cell dynamics involving i) oogonial proliferation and entry into meiosis producing an oversupply of oocytes and ii) large-scale germ cell death resulting in markedly reduced numbers surviving as the primordial follicle reserve. Our understanding of the processes maintaining the reserve comes primarily from genetically engineered mouse models, experimental activation or destruction of oocytes, and quantitative histological analysis. As the source of ovulated oocytes in postnatal life, the primordial follicle reserve requires regulation of i) its survival or maintenance, ii) suppression of development (dormancy), and iii) activation for growth and entry into folliculogenesis. The mechanisms influencing these alternate and complex inter-related phenomena remain to be fully elucidated. Drawing upon direct and indirect evidence, we discuss the controversial concept of postnatal oogenesis. This posits a rare population of oogonial stem cells that contribute new oocytes to partially compensate for the age-related decline in the primordial follicle reserve.Reproduction (2013) 146 R205-R215

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“…They are thought to be in a prolonged G2 phase, since the last round of DNA replication occurred in the embryonic gonad, before the entry of the germ cells into meiosis (Peters et al, 1962;Lima-de-Faria and Borum, 1962). Prolonged arrest in G2 implies that, the DNA replication must be repressed until after the completion of cell division (two meiotic divisions in mouse oocytes).…”

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confidence: 99%