Deoxyribonucleic Acid (Dna) Content of Human Ovarian Tumors in Relation to Histological Grading

Atypical Cells in the Peripheral Blood A Cytological Study Applied to Cancer Research

“…In cases where the values were near to triploidy [102,105,106] or highly polyploid [24,107] the forecast is more unfavorable. Thus the study of the DNA content of circulating cancer cells, at least cancer cells of epithelial origin, may have a definite prognostic value in cancer research [7,8,9,15,103,107], It is worth noting that tumor cells exhibit great constancy in their modified karyotypes. This seems to indicate that they belong to definite cell clones, each type originating from one atypical cell in which the chromosomal abnormality first appeared.…”

DNA Content and Chromosome Number in Twenty–five Human Carcinomas

“…This becomes particul arly useful if we consider that, according to A t k i n [2, 3, 4], A t k i n et al [13], B a d e r et al [14], H a u s c h a et al [18], P a u l e t e -V a n r e l l etal. [33] and R e v e s z and N o r m a n [34,35], the knowledge of chromo some ploidy may be of significance from the point of view of adequate tumour therapy or for the purpose of a better evaluation of the patient's prognosis.…”

“…If we assume that there is some kind of relation between nuclear volume and DNA content in tumor cells, as proposed by V a l e r i [39], and between DNA content and chromosome ploidy, which is likely [1,10,14], then we have to consider the possibility of determining, in an indirect way, the approximate chromosome number in cells of malignant tumours by simple DNA estimation. This becomes particul arly useful if we consider that, according to A t k i n [2,3,4], A t k i n et al [13], B a d e r et al [14], H a u s c h a et al [18], P a u l e t e -V a n r e l l etal.…”