Deoxynivalenol in cereal-based baby food production process. A review

Pascari, Xenia; Marı́n, Sonia; Ramos, Ana M. González; Gahete, Francisco Molino; Sanchis, Vicente

doi:10.1016/j.foodcont.2018.12.014

Cited by 27 publications

(13 citation statements)

References 84 publications

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“…Deoxynivalenol, also denoted as vomitoxin, is produced by fungi of the Fusarium genus, mainly by Fusarium graminearum and F. culmorum, which are both associated with FHB disease (Fusarium head blight) in cereals, especially oats, barley, wheat rye, and maize, and less frequently in rice, sorghum, and triticale [17,146]; it also contaminated cereal-derived food products such as bread, pasta, or beer. DON is the predominant trichothecene all over the world, although it is among the least toxic of the trichothecenes, and its occurrence is considered to be an indicator of the potential presence of other, more toxic trichothecenes [53].…”

Section: Trichothecenes Type B (Deoxynivalenol)mentioning

confidence: 99%

“…The maximum level of DON of 200 µg/kg was set by the EU in cereal-based baby foods for infants and young children, as well as levels of 750 µg/kg in flour and 500 µg/kg in breads [146]. At high temperatures, DON is a very stable trichothecene (120 • C, moderately stable at 180 • C), as well as soluble in water and in polar solvents such as aqueous methanol, acetonitrile, and ethyl acetate [148], and it is found during the storage and processing of products [100].…”

Section: Trichothecenes Type B (Deoxynivalenol)mentioning

confidence: 99%

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Advances in Occurrence, Importance, and Mycotoxin Control Strategies: Prevention and Detoxification in Foods

Agriopoulou

Stamatelopoulou

Varzakas

2020

Foods

436

388

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Mycotoxins are toxic substances that can infect many foods with carcinogenic, genotoxic, teratogenic, nephrotoxic, and hepatotoxic effects. Mycotoxin contamination of foodstuffs causes diseases worldwide. The major classes of mycotoxins that are of the greatest agroeconomic importance are aflatoxins, ochratoxins, fumonisins, trichothecenes, emerging Fusarium mycotoxins, enniatins, ergot alkaloids, Alternaria toxins, and patulin. Thus, in order to mitigate mycotoxin contamination of foods, many control approaches are used. Prevention, detoxification, and decontamination of mycotoxins can contribute in this purpose in the pre-harvest and post-harvest stages. Therefore, the purpose of the review is to elaborate on the recent advances regarding the occurrence of main mycotoxins in many types of important agricultural products, as well as the methods of inactivation and detoxification of foods from mycotoxins in order to reduce or fully eliminate them.

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Section: Trichothecenes Type B (Deoxynivalenol)mentioning

confidence: 99%

Section: Trichothecenes Type B (Deoxynivalenol)mentioning

confidence: 99%

Advances in Occurrence, Importance, and Mycotoxin Control Strategies: Prevention and Detoxification in Foods

Agriopoulou

Stamatelopoulou

Varzakas

2020

Foods

436

388

View full text Add to dashboard Cite

show abstract

“…(right ear (thickness at 24 h − thickness at 0 h)) − (left ear (thickness at 24 h − thickness at 0 h)) = DTH (µm) (2) The measurements were performed in randomized order and blinded.…”

Section: Vaccine-specific Immunoglobulins (Igs) In Serummentioning

confidence: 99%

“…The mycotoxin deoxynivalenol (DON) is a highly prevalent food contaminant, known to induce immunotoxicity in humans and animals. DON is produced as a secondary metabolite from Fusarium fungus species, which contaminates human food at a global level, especially cereal and grain-based products [ 1 , 2 ]. Acute and chronic exposure to DON have significant negative impact on intestinal, neurological and reproductive systems [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Human Milk Oligosaccharide 3′-GL Improves Influenza-Specific Vaccination Responsiveness and Immunity after Deoxynivalenol Exposure in Preclinical Models

et al. 2021

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Deoxynivalenol (DON), a highly prevalent mycotoxin food contaminant, is known to have immunotoxic effects. In the current study, the potential of dietary interventions with specific mixtures of trans-galactosyl-oligosaccharides (TOS) to alleviate these effects were assessed in a murine influenza vaccination model. Vaccine-specific immune responses were measured in C57Bl/6JOlaHsd mice fed diets containing DON, TOS or a combination, starting 2 weeks before the first vaccination. The direct effects of TOS and its main oligosaccharide, 3′-galactosyl-lactose (3′-GL), on DON-induced damage were studied in Caco-2 cells, as an in vitro model of the intestinal epithelial barrier. Exposure to DON significantly reduced vaccine-specific immune responses and the percentages of Tbet+ Th1 cells and B cells in the spleen. DON significantly altered epithelial structure and integrity in the ileum and reduced the SCFA levels in the cecum. Adding TOS into DON-containing diets significantly improved vaccine-specific immune responses, restored the immune cell balance in the spleen and increased SCFA concentrations in the cecum. Incubating Caco-2 cells with TOS and 3′-GL in vitro further confirmed their protective effects against DON-induced barrier disruption, supporting immune modulation. Overall, dietary intervention with TOS can attenuate the adverse effects of DON on Th1-mediated immune responses and gut homeostasis. These beneficial properties might be linked to the high levels of 3′-GL in TOS.

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“…Epidemiological studies from different geographical regions have shown that pregnant women and newborns are highly exposed to different mycotoxins (2). Deoxynivalenol (DON), a trichothecene mycotoxin produced by different Fusarium fungi species, is one of the most prevalent mycotoxins occurring in human food (12). DON exhibits intestinal, neurological, reproductive and immunotoxicity (13).…”

Section: Introductionmentioning

confidence: 99%

Exposure to Deoxynivalenol During Pregnancy and Lactation Enhances Food Allergy and Reduces Vaccine Responsiveness in the Offspring in a Mouse Model

et al. 2021

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Deoxynivalenol (DON), a highly prevalent contaminant of grain-based products, is known to induce reproductive- and immunotoxicities. Considering the importance of immune development in early life, the present study investigated the effects of perinatal DON exposure on allergy development and vaccine responsiveness in the offspring. Pregnant mice received control or DON-contaminated diets (12.5 mg/kg diet) during pregnancy and lactation. After weaning, female offspring were sensitized to ovalbumin (OVA) by oral administration of OVA with cholera toxin (CT). Male offspring were injected with Influvac vaccine. OVA-specific acute allergic skin response (ASR) in females and vaccine-specific delayed-type hypersensitivity (DTH) in males were measured upon intradermal antigen challenge. Immune cell populations in spleen and antigen-specific plasma immunoglobulins were analyzed. In female CT+OVA-sensitized offspring of DON-exposed mothers ASR and OVA-specific plasma immunoglobulins were significantly higher, compared to the female offspring of control mothers. In vaccinated male offspring of DON-exposed mothers DTH and vaccine-specific antibody levels were significantly lower, compared to the male offspring of control mothers. In both models a significant reduction in regulatory T cells, Tbet+ Th1 cells and Th1-related cytokine production of the offspring of DON-exposed mothers was observed. In conclusion, early life dietary exposure to DON can adversely influence immune development in the offspring. Consequently, the immune system of the offspring may be skewed towards an imbalanced state, resulting in an increased allergic immune response to food allergens and a decreased immune response to vaccination against influenza virus in these models.

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Deoxynivalenol in cereal-based baby food production process. A review

Abstract: Està subjecte a una llicència de Reconeixement-NoComercial-SenseObraDerivada 4.

Cited by 27 publications

References 84 publications

Advances in Occurrence, Importance, and Mycotoxin Control Strategies: Prevention and Detoxification in Foods

Advances in Occurrence, Importance, and Mycotoxin Control Strategies: Prevention and Detoxification in Foods

Human Milk Oligosaccharide 3′-GL Improves Influenza-Specific Vaccination Responsiveness and Immunity after Deoxynivalenol Exposure in Preclinical Models

Exposure to Deoxynivalenol During Pregnancy and Lactation Enhances Food Allergy and Reduces Vaccine Responsiveness in the Offspring in a Mouse Model

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