Deoxynivalenol exposure induces liver damage in mice: Inflammation and immune responses, oxidative stress, and protective effects of Lactobacillus rhamnosus GG

Bai, Yongsong; Ma, Kaidi; Li, Jibo; Li, Jianping; Bi, Chongpeng; Shan, Anshan

doi:10.1016/j.fct.2021.112514

Cited by 39 publications

(26 citation statements)

References 64 publications

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“…26 LGG also mitigated DON exposure to liver damage in mice. 7 LGG reduces the absorption of aflatoxin B1 (AFB1) in the gastrointestinal tract by increasing Holstein excretion, and reduces the toxicity of AFB1. 27 Based on these properties, LGG has great potential as an antidote to mycotoxins.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus rhamnosus GG ameliorates deoxynivalenol-induced kidney oxidative damage and mitochondrial injury in weaned piglets

Bai

et al. 2022

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Lactobacillus rhamnosus GG ameliorates deoxynivalenol-induced kidney oxidative damage and mitochondrial injury in weaned piglets

Bai

et al. 2022

Food Funct.

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“…TLR4 can recruit MyD88 to trigger nuclear factor-κB (NF-κB) and promote the transcription of inflammatory factors [ 11 , 12 ]; TLR4 also recognizes lipopolysaccharide and induce pro-inflammatory reaction [ 13 ]. Furthermore, overexpression of TLR4 has been demonstrated to worsen tissue damage and inflammation [ 14 ]. In vivo, cold stress has been proven to activate the TLR4 pathway [ 15 ], resulting in tissue damage, but little research exists on the small intestinal mucosa.…”

Section: Introductionmentioning

confidence: 99%

Dietary Glucose Ameliorates Impaired Intestinal Development and Immune Homeostasis Disorders Induced by Chronic Cold Stress in Pig Model

Sun

Song

Zou

et al. 2022

IJMS

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Endotherms are easily challenged by chronic cold stress. In this study, the development and injury of the small intestine in the Min pig model and Yorkshire pig model under chronic cold stress, and the molecular mechanisms by which glucose supplementation reduces small intestinal mucosal damage were investigated. The results showed that morphological structure lesions of the jejunal mucosa and ileal mucosa were visible in Yorkshire pigs under chronic cold stress. Meanwhile, the Occludin mRNA and protein expression in jejunal mucosa of Yorkshire pigs was decreased. Chronic cold stress enhanced the expression of Toll-like receptor 4 (TLR4), the myeloid differentiation main response 88 (MyD88), nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), cleaved caspase-1, mature-IL-1β, and high-mobility group box 1 (HMGB 1) mRNA and protein expression in jejunal mucosa of Yorkshire pigs, whereas the mRNA and protein of Bax was triggered in ileal mucosa. In Min pigs, no such deleterious consequences were observed. Dietary glucose supplementation ameliorates small intestinal mucosal injury, declined TLR4 and MyD88 expression in jejunal mucosa. In conclusion, chronic cold stress induced the small intestinal mucosa damage in Yorkshire pigs, whereas glucose supplementation mitigated the deleterious effects of chronic cold stress on the small intestine.

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“…Regarding the laboratory data, the higher levels of AST and LDH in the No-Vax in comparison with both the Pre-Vax and Vax groups could be related to their more severe respiratory failure. Hypoxia in COVID-19 patients could lead to hepatocellular necrosis through the marked increase in reactive oxygen species and the following release of hepatotoxic pro-inflammatory factors [ 27 ]. Abnormal levels of LDH can also result from reduced oxygenation [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Evolution of the Clinical Profile and Outcomes of Unvaccinated Patients Affected by Critical COVID-19 Pneumonia from the Pre-Vaccination to the Post-Vaccination Waves in Italy

et al. 2022

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The vaccination campaign and the new SARS-CoV-2 variants may have changed the clinical profile and outcomes of patients admitted to sub-intensive unit care. We conducted a retrospective study aimed to compare the clinical and radiological features of unvaccinated critical COVID-19 patients hospitalized during the last pandemic wave (December 2021–February 2022, No-Vax group) and before starting the vaccination campaign (March–December 2020, Pre-Vax group). The No-Vax group was also compared with vaccinated patients of the same pandemic wave (Vax group). With respect to the Pre-Vax group, the No-Vax group contained a higher percentage of smokers (p = 0.0007) and a lower prevalence of males (p = 0.0003). At admission, the No-Vax patients showed both a higher CT score of pneumonia and a worse severe respiratory failure (p < 0.0001). In the No-Vax group, a higher percentage of deaths occurred, though this was not significant. In comparison with the No-Vax group, the Vax patients were older (p = 0.0097), with a higher Charlson comorbidity index (p < 0.0001) and a significantly lower HRCT score (p = 0.0015). The percentage of deaths was not different between the two groups. The No-Vax patients showed a more severe disease in comparison with the Pre-Vax patients, and were younger and had fewer comorbidities than the Vax patients.

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Deoxynivalenol exposure induces liver damage in mice: Inflammation and immune responses, oxidative stress, and protective effects of Lactobacillus rhamnosus GG

Cited by 39 publications

References 64 publications

Lactobacillus rhamnosus GG ameliorates deoxynivalenol-induced kidney oxidative damage and mitochondrial injury in weaned piglets

Lactobacillus rhamnosus GG ameliorates deoxynivalenol-induced kidney oxidative damage and mitochondrial injury in weaned piglets

Dietary Glucose Ameliorates Impaired Intestinal Development and Immune Homeostasis Disorders Induced by Chronic Cold Stress in Pig Model

Evolution of the Clinical Profile and Outcomes of Unvaccinated Patients Affected by Critical COVID-19 Pneumonia from the Pre-Vaccination to the Post-Vaccination Waves in Italy

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