Deoxynivalenol and its modified forms: key enzymes, inter-individual and interspecies differences in metabolism

Wang, Yating; Li, Jiefeng; Wang, Xu; Wu, Weijie; Nepovimová, Eugenie; Wu, Qinghua; Kuča, Kamil

doi:10.1080/03602532.2022.2088786

Cited by 3 publications

(1 citation statement)

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“…This is consistent with observations from various epidemiological studies [ 9 , 26 ]. However, the ratio of glucuronidated metabolites to total excreted DON also appears to vary between sexes and age groups [ 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. Therefore, within a HBM4EU interlaboratory study, the total urinary DON (free DON, deglucuronidated DON-15-GlcA, and DON-3-GlcA) was selected as the preferred biomarker of DON exposure.…”

Section: Resultsmentioning

confidence: 99%

Human Biomonitoring Guidance Values for Deoxynivalenol Derived under the European Human Biomonitoring Initiative (HBM4EU)

Mengelers,

van den Brand,

Zhao

et al. 2024

Toxins

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The mycotoxin deoxynivalenol (DON) was one of the priority substances in the European Joint Human Biomonitoring Initiative (HBM4EU) project. In this study, to better interpret the actual internal exposure of DON in the general population and safeguard public health, human biomonitoring guidance values of DON for the general population (HBM-GVGenPop) were derived. The HBM-GVGenPop of DON was based on either the total DON (DON and its glucuronides) or DON’s main metabolite (DON-15-GlcA) levels in 24-h urine samples, resulting in a HBM-GVGenPop of 0.023 µg/mL for the total DON or a HBM-GVGenPop of 0.020 µg/mL for DON-15-GlcA. The use of 24-h urine samples is recommended based on the fact that DON and its metabolites have a short elimination half-life (T1/2), and 95% of the cumulative amount was excreted within 12 h after DON intake. The T1/2 for DON, DON-15-GlcA, and total DON were estimated to be 2.55 h, 2.95 h, and 2.95 h, respectively. Therefore, a 24-h urine sample reflects almost all of the DON exposure from the previous day, and this type of sample was considered for the derivation of a HBM-GVGenPop for DON.

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