“…He observed no improvement when desoxycorticosterone acetate was used alone and suggested that the results were due to an oxidation product of that sub stance. Landsberg et al (251), using the same treatment, felt that only patients in whom the arthritis was associated with loss of wei:�ht, depres sions, vasomotor disturbances, and loss of locomotive power were likely to benefit from the method of Lewin. Because of the somewhat favorable early reports, there was a widespread use of this combined treatment throughout the country.…”