Deorphanizing solute carriers in Saccharomyces cerevisiae for secondary uptake of xenobiotic compounds
Iben Møller-Hansen,
Javier Sáez-Sáez,
Steven A. van der Hoek
et al.
Abstract:The exchange of small molecules between the cell and the environment happens through transporter proteins. Besides nutrients and native metabolic products, xenobiotic molecules are also transported, however it is not well understood which transporters are involved. In this study, by combining exo-metabolome screening in yeast with transporter characterization in Xenopus oocytes, we mapped the activity of 30 yeast transporters toward six small non-toxic substrates. Firstly, using LC–MS, we determined 385 compou… Show more
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