Denture stomatitis treated with photodynamic therapy: five cases

Mima, Ewerton Garcia de Oliveira; Pavarina, Ana Cláudia; Silva, Mariana Montenegro; Ribeiro, Daniela Garcia; Vergani, Carlos Eduardo; Kurachi, Cristina; Bagnato, Vanderlei Salvador

doi:10.1016/j.tripleo.2011.05.019

Cited by 47 publications

(69 citation statements)

References 37 publications

(59 reference statements)

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“…7,[22][23][24] It is important to establish protocols that enhance the selectivity of the photodynamic process toward microbial targets for the clinical application of aPDT, with minimal collateral damage to the hosts. 25,26 It is also important to establish protocols for the complete removal of bacteria without damaging cells when removing bacteria from cell lines using aPDT.…”

Section: Discussionmentioning

confidence: 99%

Mycoplasma Removal from Cell Culture Using Antimicrobial Photodynamic Therapy

Hasebe

Ishikawa

Shamsul³

et al. 2013

Photomedicine and Laser Surgery

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Objective: The objective of this research was to determine the effectiveness of antimicrobial photodynamic therapy (aPDT) in the removal of mycoplasmas from contaminated cells. Background data: Mycoplasmas often contaminate cell cultures. The cell-contaminating mycoplasmas are removed by antibiotics, but the use of antibiotics usually induces antibiotic-resistant bacteria. aPDT is expected to be a possible alternative to antibiotic treatments for suppressing infections. Materials and Methods: Mycoplasma salivarium (Ms)-infected human embryonic kidney (HEK) 293 cells were irradiated using a red light-emitting diode (LED) in the presence of methylene blue (MB) as a photosensitizer. The Ms viable count was determined using culture on agar plates or using a mycoplasma detection kit. Results: aPDT performed using red LED irradiation was effective in decreasing live Ms in the presence of MB without damaging the HEK293 cells. aPDT removed live Ms from the infected cells after washing the cells with sterilized phosphate-buffered saline (PBS) to decrease the initial number of live Ms before aPDT. Conclusions: This study suggests that aPDT could remove mycoplasmas from contaminated cells.

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Section: Discussionmentioning

confidence: 99%

Mycoplasma Removal from Cell Culture Using Antimicrobial Photodynamic Therapy

Hasebe

Ishikawa

Shamsul³

et al. 2013

Photomedicine and Laser Surgery

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“…Mima et al described the treatment results of five cases infected with C. albicans [76]. Four patients showed a resolution of candidiasis after photodisinfection.…”

Section: Fungicidal Efficacy Of Photodisinfectionmentioning

confidence: 99%

Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases

Prażmo¹,

Kwaśny²,

Łapiński³

et al. 2016

Adv Clin Exp Med

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Section: Introductionmentioning

confidence: 99%

“…In vivo investigations have also demonstrated the photoinactivation of C. albicans using animal models [22][23][24], as well as treatment of patients with OC [25,26]. Hematoporphyrin derivatives (HpD) are among the earliest type of PS used [10], and light-emitting diodes (LED) have been successfully used for PDT due to their lower cost and easier technology than lasers [25,27]. Previous studies have shown that the association of porphyrin and blue LED light resulted in reduction of C. albicans counts in disinfection of dentures [21,25,27] and was also effective in the treatment of denture-related OC [25,26].…”

Section: Introductionmentioning

confidence: 99%

The influence of photodynamic therapy parameters on the inactivation ofCandidaspp:in vitroandin vivostudies

Alves¹,

Mima²,

Dovigo³

et al. 2014

Laser Phys.

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The influence of parameters of photodynamic therapy (PDT), such as pre-irradiation time (PIT), on the inactivation of Candida spp. was assessed in vitro and in vivo. Suspensions of Candida albicans, Candida tropicalis, Candida krusei and Candida glabrata were treated with Photogem R , incubated for 5, 10 or 15 min and illuminated with a blue LED light. Colonies were cultivated and log values of CFU ml −1 were analyzed by ANOVA and Kruskall-Wallis test. For in vivo evaluation, immunosuppressed mice were inoculated with C. albicans. PDT was performed on the dorsum of the tongue by topical administration of Photogem R and illumination after 5, 10 or 15 min. C. albicans was recovered from the tongue and the number of CFU ml −1 was analyzed by ANOVA and Tukey test. Animals were killed and the tongues were surgically removed for histological analysis. Susceptibility of Candida spp. suspensions to PDT was in decreasing order: C. albicans = C. tropicalis < C. krusei < C. glabrata. No significant difference was observed among the different PIT ( p > 0.05), both in vivo and in vitro. A significant reduction ( p < 0.05) of log(CFU ml −1 ) of C. albicans from tongues of mice was observed with no adverse effects in the tissue. PDT was effective to inactivate in vitro Candida spp. and for reduction of C. albicans in vivo, independently of the PIT used.

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Denture stomatitis treated with photodynamic therapy: five cases

Abstract: PDT appears to be an alternative treatment for DS.

Cited by 47 publications

References 37 publications

Mycoplasma Removal from Cell Culture Using Antimicrobial Photodynamic Therapy

Mycoplasma Removal from Cell Culture Using Antimicrobial Photodynamic Therapy

Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases

The influence of photodynamic therapy parameters on the inactivation ofCandidaspp:in vitroandin vivostudies

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