Dentinogenic ghost cell tumor – Case report of a rare entity

Abstract

Highlights There are several entities that can cause a head and neck expansive bone lesion and it’s important to consider a neoplastic cause. This report presents the case of a patient with a central dentinogenic ghost cell tumor. The patient underwent an extensive local resection and 10 months after surgery there are no signs of local recurrence. Due to its rarity, increased clinical awareness about this entity is essential to optimize the approach of these patients.

Etiology, management of ptosis in working age group and its surgical outcome – A prospective study

“…The central DGCT having a more aggressive behavior. 7 The average age for the presentation of this lesion is 50 years (range: 17-72 years), with slight male predilection. 8 The frequently affected sites are posterior maxilla and mandible with a slight predilection for mandible.…”

Dentinogenic Ghost Cell Tumor: An Unusual Aggressive Oral Lesion

“…A dentinogenic ghost cell tumor (DGCT) is a rare entity with only about 60 cases reported in the literature. 3 DGCT's are benign, mixed epithelial and mesenchymal odontogenic tumors with locally aggressive behavior. They are a subset of Calcifying Odontogenic Tumors with both a cystic type (Type I) and a solid type (Type II).…”

“…5 The two characteristic features of DGCT that distinguish it from an ameloblastoma and other odontogenic tumors are numerous ghost cells and masses of dentinoid material. 3 Excision is recommended for intraosseous lesions and a more conservative excision is recommended for extraosseous tumors. It is recommended to perform a wide range of resection due to the high reoccurrence rate, and therefore, long-term follow-up is recommended.…”

Dentinogenic Ghost Cell Tumour, a rare case of an African young female patient: Review of literature and report of a case

“…20 These tumours have strong male predilection. 3,10 Of the 7 individual cases reported, four were in males 5,18,19,20 and three in females [21][22][23] . All the females were in the fifth and sixth decade of life.…”

“…1 The appearance of either radiolucency or mixed radiolucent-radiopacity of the lesion directly depends on the degree of calcification. 22 Majority of cases are unilocular but multilocular lesions may be observed 23 These tumours are typically well-defined, often expansile and may result in resorption and divergence of roots of adjacent teeth. 24 Radiologic differential diagnosis of the current case (with mixed radiolucent-radiopacity) includes COC, Adenomatoid Odontogenic Tumour (AOT), Calcifying Odontogenic Epithelial Tumour (CEOT) and Ossifying Fibroma.…”