Dentinogenic ghost cell tumor: histologic aspects, immunohistochemistry, lectin binding profiles, and biophysical studies

Mori, Masahiko; Kasai, Tadakatsu; Nakai, Michiaki; Sato, Kimihiko; Takeuchi, Hiroshi; Takai, Yoshiaki; Kanematsu, Nobutake

doi:10.1016/s1368-8375(99)00056-1

Cited by 25 publications

(14 citation statements)

References 29 publications

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“…It tends to occur in males and is usually asymptomatic. In the present report of 7 cases, only 1 patient had slight pain and numbness, in agreement with the report of Mori et al 10 .…”

Section: Discussionsupporting

confidence: 94%

The diagnosis and treatment of dentinogenic ghost cell tumor

Sun

Huang

et al. 2009

International Journal of Oral and Maxillofacial Surgery

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“…It tends to occur in males and is usually asymptomatic. In the present report of 7 cases, only 1 patient had slight pain and numbness, in agreement with the report of Mori et al 10 .…”

Section: Discussionsupporting

confidence: 94%

The diagnosis and treatment of dentinogenic ghost cell tumor

Sun

Huang

et al. 2009

International Journal of Oral and Maxillofacial Surgery

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“…3). 81 DGCT is sometimes accompanied by COC, and the DGCT dentinoid materials are eosinophilic, amorphous, and sometimes undergo transformation into osteodentin 82. Furthermore, dendritic cells representing Langerhans cells and melanocytes often infiltrate into tumoral epithelium 83…”

Section: Dentinogenic Ghost Cell Tumormentioning

confidence: 99%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Lee

Kim

2014

Korean J Pathol

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Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differentially, GCOTs are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinoma (GCOC), all derived from calcifying odontogenic cysts (COCs). There is considerable confusion about COCs and GCOTs terminology, but these lesions can be classified as COCs or GCOTs, based on their cystic or tumorous natures, respectively. GCOTs include ameloblastomatous tumors derived from dominant odontogenic cysts classified as CCOTs, ghost cell-rich tumors producing dentinoid materials as DGCTs, and the GCOT malignant counterpart, GCOCs. Many authors have reported CEOTs and GCOTs variably express keratins, β-catenin, BCL-2, BSP, RANKL, OPG, Notch1, Jagged1, TGF-β, SMADs, and other proteins. However, these heterogeneous lesions should be differentially diagnosed to allow for accurate tumor progression and prognosis prediction.

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“…DGCT is a benign neoplasm of odontogenic epithelium predominantly consisting of ameloblastomatous proliferations. Some tumors have a significant component of basaloid hyperchromatic and isomorphic cells, displayed as sheets . Ghost cells and dentin‐like or osteodentin‐like material can also be found .…”

Section: Introductionmentioning

confidence: 99%

“…Retrospective studies, case reports, or case series with a significant number of COC cases have been published in the English scientific literature . In contrast, reports on DGCT and GCOC are scarce . To the best of our knowledge, no systematic review about clinicoradiological appearance and therapy of COC, DGCT, and GCOC has been found in the literature thus far.…”

Section: Introductionmentioning

confidence: 99%