Dentinogenic Ghost Cell Tumor associated with Odontoma: A unique Histopathological Entity and its Surgical Management

Urs, Aadithya B; Jot, Kiran; Maheswari, R; Gupta, Arpit; Mohanty, Sujata

doi:10.17796/1053-4625-46.2.10

Cited by 5 publications

(5 citation statements)

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“…In our case, odontomas and DGCT coexisted in the same area. This is an extremely rare condition and has only been reported in four other cases besides the present one 11–14 …”

Section: Discussionmentioning

confidence: 55%

“…This is an extremely rare condition and has only been reported in four other cases besides the present one. [11][12][13][14] Surgical excision is the treatment of choice for DGCT, and the extent of surgical excision required depends on the size and location of the lesion. The recurrence rate of DGCT has been reported to be 10%-20%, highlighting the importance of long-term follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…This is an extremely rare condition and has only been reported in four other cases besides the present one. 11 , 12 , 13 , 14 …”

Section: Discussionmentioning

confidence: 99%

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A rare case of dentinogenic ghost cell tumor with concomitant odontoma

Okui

Morioka

Iwahashi

et al. 2023

Clinical Case Reports

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Dentinogenic ghost cell tumor (DGCT), a rare odontogenic tumor accounting for less than 0.5% of all odontogenic tumors, arises from the epithelial remnants of dental lamina or enamel. 1 Odontoma, a benign tumor-like lesion, consists of dental tissues such as enamel, dentin, cementum, and pulp. 2 Although both tumors are benign, they may cause complications depending on their location and size. DGCT is usually asymptomatic and presents as a painless swelling in the oral and maxillofacial region. Radiographically, DGCT appears as a well-defined radiolucent lesion with calcified areas. 3 Histopathologically, it is characterized by the presence of ghost cells, dentin, and calcified tissue. 4 Although DGCT is considered a benign tumor, it can be locally aggressive and has the potential to recur. 5 Here we present an extremely rare case of combined DGCT and odontoma, in which lesions with each pathology occurred at the same site simultaneously in a middle-aged female patient. | CASE REPORTA 32-year-old female presented to Shimane University Hospital with a painless swelling in her left maxilla that had

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“…In our case, odontomas and DGCT coexisted in the same area. This is an extremely rare condition and has only been reported in four other cases besides the present one 11–14 …”

Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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A rare case of dentinogenic ghost cell tumor with concomitant odontoma

Okui

Morioka

Iwahashi

et al. 2023

Clinical Case Reports

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“…In the present case, small areas composed of tubular dentin and dental papilla adjacent to epithelium resembling enamel organ, that were identified as early odontoma, were detected. Whereas, in COC, a simple cyst type of OGCL, about 20% of cases are associated with dental hard tissues resembling odontoma, 9 DGCT with odontoma is extremely rare, only three cases reported in literature, and all of them were central lesions 10 …”

Section: Discussionmentioning

confidence: 99%

“…Whereas, in COC, a simple cyst type of OGCL, about 20% of cases are associated with dental hard tissues resembling odontoma, 9 DGCT with odontoma is extremely rare, only three cases reported in literature, and all of them were central lesions. 10 F I G U R E 4 (a) Ameloblastoma-like nests are seen in mature connective tissue stroma. Ki-67 labeling index is 2% (insert).…”

Section: Pathological Findingsmentioning

confidence: 99%

Ghost cell odontogenic carcinoma arising in dentinogenic ghost cell tumor, peripheral: A case report

Sakamoto

Ando

Mizuta

et al. 2023

Pathology International

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Ghost cell odontogenic carcinoma (GCOC) is an extremely rare intraosseous malignant odontogenic tumor with prominent ghost cell keratinization and dentinoid formation. Here, we present the first case of GCOC arising in dentinogenic ghost cell tumor (DGCT), peripheral. The patient was a man in his 60s with an exophytic mass in the anterior part of lower gingiva. The resected tumor measured 4.5 cm in maximum diameter. Histologically, the nonencapsulated tumor proliferated in the gingiva without bone invasion. It was predominantly composed of ameloblastoma‐like nests and islands of basaloid cells with ghost cells and dentinoid in the mature connective tissue, suggesting DGCT, peripheral. As minor components, sheets of atypical basaloid cells and ameloblastic carcinoma‐like nests with pleomorphism and high proliferative activity (Ki‐67 labeling index up to 40%) consistent with malignancy were identified. CTNNB1 mutation and β‐catenin nuclear translocation were observed in both benign and malignant components. Final diagnosis was GCOC arising in DGCT, peripheral. GCOC shows similar histological features to DGCT. In this unique case without invasion, the cytological atypia and high proliferative activity supports the diagnosis of malignant transformation from DGCT.

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Central dentinogenic ghost cell tumor of the maxilla: a case report with new imaging findings and review of the literature

Yoshida,

Takeshita,

Kawazu

et al. 2024

Oral Radiol

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A dentinogenic ghost cell tumor (DGCT) is a rare benign odontogenic tumor that commonly shows characteristics of solid proliferation and has a relatively high risk of recurrence after surgical treatment. We herein report a case of a central DGCT that occurred in the maxilla and resulted in bone expansion. This study highlights new imaging findings (particularly magnetic resonance imaging) along with histopathological observations. In addition, we conducted a review of the existing literature on this rare tumor. A 37-year-old man developed swelling around the right cheek. A benign odontogenic tumor such as ameloblastoma was suspected based on the imaging examination findings (including bone expansion and the internal characteristics of the tumor) on panoramic imaging, computed tomography, and magnetic resonance imaging. The lesion was surgically excised from the right maxilla. Postoperative histopathological examination led to a definitive diagnosis of central DGCT. The tumor comprised epithelial neoplastic islands, resembling ameloblastoma, inside tight fibroconnective tissue; masses of ghost cells and formation of dentin were also observed. We had suspected that the minute high-density region around the molars on the imaging examinations represented alveolar bone change; however, it represented dentin formation. This led to difficulty diagnosing the lesion. Although DGCT may present characteristic findings on imaging examinations, its occurrence is infrequent, and in some cases, the findings may include the presence or absence of an impacted tooth without obvious calcification. The present case suggests that we should consider the possibility of an odontogenic tumor with calcification when high-density structures are observed inside the lesion.

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Dentinogenic Ghost Cell Tumor associated with Odontoma: A unique Histopathological Entity and its Surgical Management

Cited by 5 publications

References 0 publications

A rare case of dentinogenic ghost cell tumor with concomitant odontoma

A rare case of dentinogenic ghost cell tumor with concomitant odontoma

Ghost cell odontogenic carcinoma arising in dentinogenic ghost cell tumor, peripheral: A case report

Central dentinogenic ghost cell tumor of the maxilla: a case report with new imaging findings and review of the literature

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