Dentinogenesis imperfecta in Osteogenesis imperfecta type XI in South Africa: a genotype–phenotype correlation

Abstract

Background The maxillofacial and dental manifestations of Osteogenesis imperfecta (OI) have significant implications in terms of management. Although the occurrence of abnormal dentine in some forms of OI is well documented, there is scant information on the association of abnormal dentine in the Black African persons with phenotypic OI III and genotypic OI XI in South Africa. Methods This was a cross-sectional analytic study. A series of 64 Black South African individuals with a confirmed phenotypic diagnosis of OI III, ages ranging from 3 months to 29 years, were assessed clinically, radiographically, and at a molecular level. Results A total number of 64 saliva samples were analyzed and 3 DNA variations were identified in exon 5 of the FKBP10 gene. The homozygous mutation, c.[831dupC]; [831dupC], was identified in 23 affected persons who had no clinically obvious features of DI in their primary and secondary teeth. Radiologically, mild features of DI were evident in 10 persons in whom radiographic images were obtained and were given a Clinical–radiological score of 2. A compound heterozygous mutation, c. [831delC]; [831dupC], was identified in three siblings. An intraoral examination of these affected persons revealed no clinically apparent features of DI in their primary and secondary teeth. Due to the lack of radiological facilities, the presence or absence of DI could not be confirmed or negated. A second compound heterozygous mutation, c.[831dupC]; [1400-4C>G], was identified in a female of 29 years belonging to the Xhosa linguistic group. Her teeth appeared clinically normal but it was not possible to obtain radiographs. In 37 affected individuals, no disease-causing mutations were identified. Conclusion Black African individuals in SA with the homozygous mutation in the FKBP10 gene have clinically unaffected teeth yet exhibited radiographic features of DI to varying degrees. This characterization is suggestive of a relationship between the genetic abnormality and the clinical manifestations of DI. The authors suggest that this diagnosis must include teeth that are clinically and/or radiologically aberrant, and should not exclude the presence of other, milder, dentinal aberrations associated with OI. There was no correlation between severity of OI and DI in this cohort of individuals.

Morphological Study of Dental Structure in Dentinogenesis Imperfecta Type I with Scanning Electron Microscopy

“…In addition, in recent decades, genetic studies have been carried out that have allowed a better understanding of both the etiopathogenesis of OI and its relationship with the systemic and dental phenotypes [ 32 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. Secondary to the early diagnosis of current OI, often even during pregnancy, the vast majority of these subjects have received pharmacological treatment from birth, usually with intravenous bisphosphonates, so it is not surprising that a relationship is found between the period or dose of administration of these drugs and the radiographic results of DGI-I [ 44 ].…”

The genetic determinants of oral diseases in Africa: The gaps should be filled

“…Recent studies in South Africa assessed osteogenesis imperfecta (OI) type 3, which has an unusually high frequency in the Black Southern African populations ( 105 ) Out of 91 patients with a confirmed phenotypic diagnosis of OI type 3, 45% of affected individuals had a pathogenic variant of the FKBP10 gene ( 105 ). Interestingly, the individuals with a homozygous mutation in the FKBP10 gene have clinically unaffected teeth yet exhibited radiographic features of dentinogenesis imperfecta to varying degrees ( 106 ). Another study evaluating the physical features of 125 individuals with Noonan syndrome found that Black Africans had the most distinctive features ( 107 ) however, the molecular detection rate in this study was only 31.2% compared to the expected >70% using whole exome sequencing (WES).…”

BDJ Open (2019-2020) and the advantages of open access publishing

“…Again, open access publishing removes those barriers. There were four such papers published in 2019-2020, 40,41,42,43 including Chetty et al's 'Dentinogenesis imperfecta in osteogenesis imperfecta type XI in South Africa: a genotype-phenotype correlation' 41 and Khan et al's ' Analysis of different characteristics of smile' . 43…”