“…In the absence of any other comparable long-term studies, our results suggested that, at best, the chance of teeth to heal in the longer-term after apical microsurgery using ProRoot MTA would be 86%, which is lower than the 94% suggested in the recent systematic review (6). This suggested prognosis is far better than that reported in previous 4-year or longer studies on apical surgery performed with other root-end filling materials and without emphasis on the microsurgical technique (8,9,11,12,13,23). Nevertheless, additional long-term, methodologically sound studies are required to augment the evidence for the prognosis after apical microsurgery using ProRoot MTA.…”