Dentin erosion prevention by matrix metalloproteinase and cysteine cathepsin inhibition

Zn-containing polymer nanogels promote cervical dentin remineralization

“…Erosion plus demineralization has been considered the main etiological factor for DH, because of the opening and enlarging of the dentin tubules [8]. In erosion, the most important role seems to be played by MMPs that reduces dentin loss [45]. Host enzyme MMPs have been demonstrated to degrade the exposed organic matrix [46].…”

Polymeric zinc-doped nanoparticles for high performance in restorative dentistry

“…Host enzyme MMPs degrade the exposed organic matrix [48], as explained before. In erosion, MMPs reduce dentin loss [132]. In partially demineralized dentin, Zn intensely reduces MMPmediated collagen degradation [48].…”

Role of Host-Derived Proteinases in Dentine Caries and Erosion

“…Those include MMP activation with pH changes, dentine collagen degradation by activated dentinal or salivary enzymes, inhibition of dentinal and salivary MMPs by specific inhibitors, a significant increase in MMP and cathepsin levels and activities in caries-infected and -affected dentine, an increase in MMP-2, -9 and -20 in dentinal fluid in tubules under caries lesions, increased MMP levels in saliva of Sjögren syndrome patients, a strong correlation between caries lesions and salivary MMP-8, identification of MMPs among dental caries susceptibility genes, and MMP-2-related defence responses in the dentine-pulp border. In erosion, the most important role seems to be played by MMPs, as revealed by a recent in vitro study where MMP but not the specific cathepsin inhibitors reduced dentine loss [Hannas et al, 2014]. The direct evidence is still relatively limited, consisting of reduction in dentinal caries progression by MMP inhibitors in animal experiments, and partial or complete reduction of dentine erosion in situ [for details, see Buzalaf et al, 2012b;Tjäderhane et al, 2013bTjäderhane et al, , 2015Hedenbjörk-Lager et al, 2015].…”