Dentate granule cell neurogenesis after seizures induced by pentylenetrazol in rats

Jiang, Wen; Wan, Qi; Zhang, Zhijun; Wang, Weidong; Huang, Yuan-Gui; Rao, Zhi-Ren; Zhang, Xia

doi:10.1016/s0006-8993(03)02438-7

Cited by 56 publications

(35 citation statements)

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“…The pro-proliferative effects of EC stimulation had distinct temporal and anatomical profiles. Similar to electroconvulsive shock (Ma et al, 2009), induced seizures (Parent et al, 1997;Jiang et al, 2003), and targeted brain stimulation (Bruel-Jungerman et al, 2006;Toda et al, 2008), increased proliferation occurred in a delayed manner and peaked 3-5 d after stimulation before returning to baseline. Furthermore, after unilateral stimulation, increased proliferation was limited to the side ipsilateral to the electrode site.…”

Section: Discussionmentioning

confidence: 97%

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Stone

Teixeira²,

DeVito³

et al. 2011

J. Neurosci.

351

284

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Deep brain stimulation (DBS)is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.

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Section: Discussionmentioning

confidence: 97%

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Stone

Teixeira²,

DeVito³

et al. 2011

J. Neurosci.

351

284

View full text Add to dashboard Cite

show abstract

“…Immunohistochemical detection of single BrdU labeling was conducted with previously described protocols (Jiang et al, 2003). Briefly, free floating sections were pretreated in 50% formamide/23 SSC buffer (0.3 M NaCl, 0.03 M sodium citrate) at 658C for 2 h and were incubated in 2 M HCl at 378C for 30 min.…”

Section: Tissue Fixation and Immunohistochemistrymentioning

confidence: 99%

“…Among all of seizure types, convulsive status epilepticus (SE) is the most severe seizure type. We have known those seizures, whether originating from the limbic system or not (Bengzon et al, 1997;Nakagawa et al, 2000;Jiang et al, 2003), whether displaying a single afterdischarge induced by hippocampal stimulation or SE induced by the chemoconvulsant (Bengzon et al, 1997;Gray and Sundstrom, 1998), can stimulate the proliferation of neural progenitors in the DG. It is not clear, however, whether different seizure severity has different effects on the proliferation, differentiation, and migration of neural progenitors in the DG.…”

Section: Introductionmentioning

confidence: 99%

Different effects of mild and severe seizures on hippocampal neurogenesis in adult rats

et al. 2008

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Recent evidence shows that functional neurogenesis exists in the adult hippocampus and that epileptic seizures can increase neurogenesis in the dentate gyrus (DG). However, it is unknown whether different seizure severity has different effects on neurogenesis in the DG of adult rats. In this study, we examined hippocampal neurogenesis in the rat mild and severe seizure preparations characterized with frequent wet dog shakes and severe status epilepticus, respectively. Both mild and severe seizures promoted the mitotic activity in the DG, but severe seizures caused a stronger cell proliferative response than mild seizures. Less than 20% of newborn cells in the DG differentiated into neurons in rats suffering severe seizures, whereas more than 60% of newborn dentate cells differentiated into neurons in control and mild seizure groups. Most newborn neurons migrated into the granular cell layer in control and mild seizure groups, but severe seizures were associated with an aberrant migration of newborn neurons into the dentate hilus. Severe seizures induced astrocyte activation and the expression of nestin and the migration directional molecules netrin 1 and Sema-3A in the hilus, which were not present in the hilus of control and mild seizure-attacked rats, suggesting that these molecules are involved in the aberrant migration of newborn neurons.

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“…Increases in hippocampal cell proliferation have been reported after kainate-or pilocarpine-induced seizures [92][93][94][95]. Jiang et al showed that increased proliferation was maintained for up to 14 days after seizures, gradually declining to the control level [96]. Parent et al have demonstrated that increased neurogenesis after seizures might contribute to aberrant reorganization of hippocampal network; later this point of view was supported and further developed by other authors [97][98][99].…”

Section: Potential Mechanisms Of First Seizure Effects On Cognitive Fmentioning

confidence: 88%

Single Seizure and Cognition: Clinical and Translational Implications

2016

ARC Journal of Neuroscience

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Dentate granule cell neurogenesis after seizures induced by pentylenetrazol in rats

Cited by 56 publications

References 50 publications

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Different effects of mild and severe seizures on hippocampal neurogenesis in adult rats

Single Seizure and Cognition: Clinical and Translational Implications

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