Dental X-ray exposure and Alzheimer’s disease: A hypothetical etiological association

Rodgers, Caroline

doi:10.1016/j.mehy.2011.03.016

Cited by 3 publications

(3 citation statements)

References 69 publications

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“…Recent data showed that rats exposed to fractionated radiation dose present reduction of neurogenesis in DG and SVZ associated with schizophrenia-like behavior [77]. Finally, it should be remarked that neural stem cells and microglial cells can be impaired several years before clinically overt neurodegenerative diseases such as sporadic Alzheimer’s and Parkinson’s disease [66,78]. At a molecular level, the major fundamental mechanism triggered in the irradiated brain and responsible for structural alterations is DNA damage followed by pro-oxidant, pro-inflammatory and enhanced apoptotic response [79].…”

Section: Reviewmentioning

confidence: 99%

“…Thus, an accurate investigation of fractionated vs acute radiation damage to neuronal/neural cells in different brain areas is needed in order to understand the link between molecular mechanisms of radiation-induced alterations and cognitive impairment. This represents an important topic, since outside the field of radiation therapy [83], the evidence linking radiation exposure to cognitive disorders is weak, especially in the case of occupationally exposed medical workers [76,78]. Yamada et al reported no relationship between radiation exposure (< 4 Gy) and dementia in 2,286 aging atomic bomb survivors [84].…”

Section: Reviewmentioning

confidence: 99%

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Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

et al. 2012

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BackgroundAccording to a fundamental law of radiobiology (“Law of Bergonié and Tribondeau”, 1906), the brain is a paradigm of a highly differentiated organ with low mitotic activity, and is thus radio-resistant. This assumption has been challenged by recent evidence discussed in the present review.ResultsIonizing radiation is an established environmental cause of brain cancer. Although direct evidence is lacking in contemporary fluoroscopy due to obvious sample size limitation, limited follow-up time and lack of focused research, anecdotal reports of clusters have appeared in the literature, raising the suspicion that brain cancer may be a professional disease of interventional cardiologists. In addition, although terminally differentiated neurons have reduced or mild proliferative capacity, and are therefore not regarded as critical radiation targets, adult neurogenesis occurs in the dentate gyrus of the hippocampus and the olfactory bulb, and is important for mood, learning/memory and normal olfactory function, whose impairment is a recognized early biomarker of neurodegenerative diseases. The head doses involved in radiotherapy are high, usually above 2 Sv, whereas the low-dose range of professional exposure typically involves lifetime cumulative whole-body exposure in the low-dose range of < 200 mSv, but with head exposure which may (in absence of protection) arrive at a head equivalent dose of 1 to 3 Sv after a professional lifetime (corresponding to a brain equivalent dose around 500 mSv).ConclusionsAt this point, a systematic assessment of brain (cancer and non-cancer) effects of chronic low-dose radiation exposure in interventional cardiologists and staff is needed.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

et al. 2012

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“…However, exact mechanisms of A β peptide-induced alterations are still obscure. On the list of other possible causative agents and factors for the development of AD is ionizing radiation (IR), particularly dental X-rays and related IR capable of destroying dividing microglial cells that support neurons [ 21 ], by damaging microglia telomeres causing premature death as proposed by Rodgers [ 22 ]. Furthermore, mitochondria are very important targets of ionizing radiation [ 23 ] and their direct damage leads to further nuclear DNA damage [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Oxygen Concentration and Oxidative Stress Modulate the Influence of Alzheimer’s Disease Aβ_1–42 Peptide on Human Cells

Džinić

Dencher

2018

Oxidative Medicine and Cellular Longevity

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Reactive oxygen species (ROS) generated after exposure to ionizing radiation and toxic peptides, in mitochondrial metabolism and during aging contribute to damage of cell's structural and functional components and can lead to diseases. Monomers and small oligomers of amyloid beta (Aβ) peptide, players in Alzheimer's disease, are recently suggested to be involved in damaging of neurons, instead of extracellular Aβ plaques. We demonstrate that externally applied disaggregated Aβ 1–42 peptide interacts preferentially with acidic compartments (lysosomes). We compared standard cell cultivation (21% O2) to more physiological cell cultivation (5% O2). Cells did not exhibit a dramatic increase in ROS and change in glutathione level upon 4 μM Aβ peptide treatment, whereas exposure to 2 Gy X-rays increased ROS and changed glutathione level and ATP concentration. The occurrence of the 4977 bp deletion in mtDNA and significant protein carbonylation were specific effects of IR and more pronounced at 21% O2. An increase in cell death after Aβ peptide treatment or irradiation was unexpectedly restored to the control level or below when both were combined, particularly at 5% O2. Therefore, Aβ peptide at low concentration can trigger neuroprotective mechanisms in cells exposed to radiation. Oxygen concentration is an important modulator of cellular responses to stress.

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An In-depth Analysis of the Adverse Effects of Ionizing Radiation Exposure on Cardiac Catheterization Staffs

Alvandi,

Javid,

Shaghaghi

et al. 2024

CRP

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Diagnostic and interventional angiograms are instrumental in the multidisciplinary approach to CAD management, enabling accurate diagnosis and effective targeted treatments that significantly enhance patient care and cardiovascular outcomes. However, cath lab staff, including interventional cardiologists, is consistently exposed to ionizing radiation, which poses inherent health risks. Radiation exposure in the cath lab primarily results from the use of fluoroscopy and cineangiography during diagnostic and interventional procedures. Understanding these risks and implementing effective radiation protection measurements are imperative to ensure the well-being of healthcare professionals while delivering high-quality cardiac care. Prolonged and repeated exposure can lead to both deterministic and stochastic effects. Deterministic effects, such as skin erythema and tissue damage, are more likely to occur at high radiation doses. Interventional cardiologists and staff may experience these effects when safety measures are not rigorously followed. In fact, while ionizing radiation is essential in the practice of radiation cardiology ward, cath lab staff faces inherent risks from radiation exposure. Stochastic effects, on the other hand, are characterized by a probabilistic relationship between radiation exposure and the likelihood of harm. These effects include the increased risk of cancer, particularly for those with long-term exposure. Interventional cardiologists, due to their frequent presence in the cath lab, face a higher lifetime cumulative radiation dose, potentially elevating their cancer risk. Protective measures, including the use of lead aprons, thyroid shields, and radiation monitoring devices, play a crucial role in reducing radiation exposure for cath lab personnel. Adherence to strict dose optimization protocols, such as minimizing fluoroscopy time and maximizing distance from the radiation source, is also essential in mitigating these risks. Ongoing research and advancements in radiation safety technology are essential in further for minimizing the adverse effects of ionizing radiation in the cath lab.

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Dental X-ray exposure and Alzheimer’s disease: A hypothetical etiological association

Cited by 3 publications

References 69 publications

Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

Oxygen Concentration and Oxidative Stress Modulate the Influence of Alzheimer’s Disease Aβ_1–42 Peptide on Human Cells

An In-depth Analysis of the Adverse Effects of Ionizing Radiation Exposure on Cardiac Catheterization Staffs

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Dental X-ray exposure and Alzheimer’s disease: A hypothetical etiological association

Cited by 3 publications

References 69 publications

Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

Oxygen Concentration and Oxidative Stress Modulate the Influence of Alzheimer’s Disease Aβ1–42 Peptide on Human Cells

An In-depth Analysis of the Adverse Effects of Ionizing Radiation Exposure on Cardiac Catheterization Staffs

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Product

Resources

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Oxygen Concentration and Oxidative Stress Modulate the Influence of Alzheimer’s Disease Aβ_1–42 Peptide on Human Cells