Dental rehabilitation of children with congenital facial defects on the background of immunotropic therapy

Митропанова, М. Н.

doi:10.37988/1811-153x_2018_3_8

Cited by 1 publication

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“…Patients with orofacial cleft are traditionally divided into three groups: cleft lip, cleft palate, and cleft lip and palate with an approximate distribution 25%, 30% and 45%, respectively [4]. CCLPs are one of the important problems of medicine due to their high prevalence, the severity of anatomical and functional disorders, the difficulty of social adaptation of patients, and the cost of treatment [5]. A wide range of gene defects has been identified as a risk factor for the development of both isolated and syndromic clefts.…”

Section: Introductionmentioning

confidence: 99%

Osteocalcin and regulatory cytokine imbalance in children with congenital cleft lip and palate

Нестерова

Митропанова

Чудилова

et al. 2020

Immunological Medicine

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The aim of the work was a comprehensive assessment of the cytokine system and peripheral blood osteocalcin with the establishment of features of their interconnections in children with congenital cleft lip and palate (CCLP) in comparison with corresponding controls at different age periods. Levels of IL17, IL4, IL6, IL1b, IFNc and osteocalcin were analyzed by enzyme immunoassay in the peripheral blood of 80 children (0-12 months, 1-3 years, 4-9 years, 10-15 years) with CCLP and age-appropriate control of healthy individuals (40 people). An analysis of the obtained data shows that in children with CCLP we revealed significant differences between pro-inflammatory (IL1b, IL6, IL17), regulatory (IFNc), anti-inflammatory (IL4) cytokines and osteocalcin compared with controls. Differences were found in the content of IL17, IFNc, IL4 and osteocalcin in healthy children and in children with CCLP in postnatal ontogenesis. Cytokine deregulation of immunosteogenesis in CCLP, leading to a significant deficit of osteocalcin in the first year of life due to imbalance of the cytokine profile: discordant IL17, IFNc and IL4 were detected. Obtained data are undoubtedly important in the future for developing new strategies for targeted therapy aimed at normalizing osteocalcin levels at different age periods in children with CCLP.

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Section: Introductionmentioning

confidence: 99%