Dental radiographic findings in cats with chronic gingivostomatitis (2002–2012)

Farcas, Nicodin; Lommer, Milinda J.; Kass, Philip H.; Verstraete, Frank J.M.

doi:10.2460/javma.244.3.339

Cited by 46 publications

(43 citation statements)

References 25 publications

(55 reference statements)

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“…In humans, it seems that many oral/oropharyngeal SCC arise from pre-existing disorders such as leukoplakia and erythroplakia [ 34 ]. Such progression has not been identified in feline oral SCC, although inflammatory conditions like periodontal disease and stomatitis are common [ 39 ]. It is possible that there are similar pre-malignant lesions in cats which, if identified, may be models for chemoprevention or other intervention strategies.…”

Section: Feline Oral Squamous Cell Carcinomamentioning

confidence: 99%

Cats, Cancer and Comparative Oncology

Cannon

2015

Veterinary Sciences

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Naturally occurring tumors in dogs are well-established models for several human cancers. Domestic cats share many of the benefits of dogs as a model (spontaneous cancers developing in an immunocompetent animal sharing the same environment as humans, shorter lifespan allowing more rapid trial completion and data collection, lack of standard of care for many cancers allowing evaluation of therapies in treatment-naïve populations), but have not been utilized to the same degree in the One Medicine approach to cancer. There are both challenges and opportunities in feline compared to canine models. This review will discuss three specific tumor types where cats may offer insights into human cancers. Feline oral squamous cell carcinoma is common, shares both clinical and molecular features with human head and neck cancer and is an attractive model for evaluating new therapies. Feline mammary tumors are usually malignant and aggressive, with the ‘triple-negative’ phenotype being more common than in humans, offering an enriched population in which to examine potential targets and treatments. Finally, although there is not an exact corollary in humans, feline injection site sarcoma may be a model for inflammation-driven tumorigenesis, offering opportunities for studying variations in individual susceptibility as well as preventative and therapeutic strategies.

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Section: Feline Oral Squamous Cell Carcinomamentioning

confidence: 99%

Cats, Cancer and Comparative Oncology

Cannon

2015

Veterinary Sciences

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“…Ulceration of the tongue and palate may also be present. In addition, FCGS has been shown to be associated with more widely distributed and severe periodontitis and with a higher prevalence of external inflammatory root resorption and retained roots than other oral diseases ( 2 ). The presence of caudal stomatitis distinguishes FCGS from other feline oral conditions ( 1 , 2 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Feline calicivirus Load, Oral Lesions, and Outcome in Feline Chronic Gingivostomatitis (Caudal Stomatitis): Retrospective Study in 104 Cats

Druet¹,

Hennet²

2017

Front. Vet. Sci.

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ObjectiveThis study was performed to assess the relationship between oral Feline calicivirus (FCV) load and severity of lesions at the time of presentation of cats suffering from feline chronic gingivostomatitis (FCGS) (part 1) and treatment outcome after dental extractions (part 2). We hypothesized that a higher FCV viral load would be positively correlated with the severity of lesions at presentation and negatively correlated with treatment outcome. In addition, the effect of dental extractions on outcome and the influence of preoperative severity of lesions on the outcome were investigated.Materials and methodsCats with FCGS were included in the study if they had been diagnosed with caudal stomatitis, had been tested positive for FCV using a real-time reverse transcriptase-PCR test on oropharyngeal swab, and had dental extractions performed within the authors’ department. General practitioners provided all previous medical treatments. Cats with recheck examinations were included in part 2 of the study. Multivariate statistical analysis was performed to assess the relationship between the different parameters.ResultsOne hundred four cats met the requirements for part 1 and 56 cats for part 2 of the study. Data collected from patients’ record included patient history, viral testing results, extent and severity of oral lesions, extent of teeth extraction. Signalment, history, preoperative treatment, and severity of caudal and alveolar stomatitis score were not associated with FCV load (P > 0.05). Presence of lingual ulcers was significantly correlated with FCV load (P = 0.0325). Clinical cure (32.1%) or very significant improvement (19.6%) was achieved in 51.8% of cats within 38 days. Concomitantly, 60.7% of the owners considered their cat cured (41.1%) or significantly improved (19.6%). Extent of teeth extraction was not found to influence the clinical outcome (P > 0.05).ConclusionThe results of this study did not support the hypothesis that FCV oral load is correlated with the severity of oral lesions or with the outcome following dental extractions. In addition, the severity of caudal inflammation was not correlated with healing time or achievement of cure.

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“…The etiology of FCGS remains elusive, but it is generally accepted that FCGS arises from an inappropriate immune response to oral antigenic stimulation, potentially multifactorial in nature and possibly with varying inciting causes ( 12 , 14 , 15 ). Myriad maladies have been implicated, from systemic pathogens (feline calicivirus, herpesvirus, leukemia virus, immunodeficiency virus, and Bartonella ), to dental disease (feline resorptive lesions, periodontal disease), to hypersensitivity (overreaction to plaque bacteria, food allergies) ( 12 , 14 , 16 – 27 ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature

2016

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Feline chronic gingivostomatitis (FCGS) is a disease characterized by protracted and potentially debilitating oral inflammation in cats, the etiology of which is currently unknown. The purpose of this review is to apply an evidence-based medicine approach to systematically review and critically evaluate the scientific literature reporting the outcome of medical and surgical management of FCGS. Those articles meeting inclusion criteria were reviewed and assigned an “Experimental Design Grade” (EDG) and an “Evidence Grade” (EG) in order to score relative strength of study design and produced data. Studies were evaluated and compared, especially highlighting the treatments, the outcomes, and the therapeutic success rates. This review found a lack of consistency between articles’ data, rendering direct comparison of results unreliable. The field of FCGS research, and ultimately patient care, would benefit from standardizing studies by adopting use of a consistent semi-quantitative scoring system and extending follow-up duration. Future researchers should commit to large prospective studies that compare existing treatments and demonstrate the promise of new treatments.

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Dental radiographic findings in cats with chronic gingivostomatitis (2002–2012)

Cited by 46 publications

References 25 publications

Cats, Cancer and Comparative Oncology

Cats, Cancer and Comparative Oncology

Relationship between Feline calicivirus Load, Oral Lesions, and Outcome in Feline Chronic Gingivostomatitis (Caudal Stomatitis): Retrospective Study in 104 Cats

Therapeutic Management of Feline Chronic Gingivostomatitis: A Systematic Review of the Literature

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