Dental pulp stem cells for treating neurodegenerative diseases

Shamir, Christopher; Venugopal, Chaitra; Dhanushkodi, Anandh

doi:10.4103/1673-5374.169629

Cited by 9 publications

(15 citation statements)

References 19 publications

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“…Despite the recent advances in the biology of neurodegenerative diseases, these disorders remains incurable, and most of the existing drugs provide only symptomatic relief and do not affect the progression of the disease [ 36 ]. For this reason, there is a pressing need to identify alternative therapies to treat these disorders [ 36 ].…”

Section: Extracellular Vesicles As Therapeutic Approach For Neurodmentioning

confidence: 99%

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Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology

Araldi

D’Amélio

Vigerelli

et al. 2020

Cells

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The aging population has contributed to the rapid rise in the global incidence of neurodegenerative diseases. Despite the medical advances, there are no effective treatments for these disorders. Therefore, there is an urgent need for new treatments for these diseases. In this sense, cell therapy has been recognized as the best candidate for treating incurable diseases, such as neurodegenerative disorders. However, the therapeutic use of these cells can be limited by several factors. Thus, there has been a rediscovery that extracellular vesicles, including exosomes, can be alternatively explored in the treatment of these diseases, overcoming the limits of cell-based therapy. In this sense, this review aims to revisit all areas from biology, including biogenesis and the content of exosomes, to biotechnology, proposing the minimal information required to isolate, characterize, and study the content of these vesicles for scientific and/or clinical purposes.

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Section: Extracellular Vesicles As Therapeutic Approach For Neurodmentioning

confidence: 99%

“…Furthermore, MSCs exhibit a homing potential to the injury sites [ 49 ]. For these reasons, the MSCs have been widely explored for cell-based treatment for different diseases, including neurodegenerative disorders [ 36 , 51 , 52 , 53 ].…”

Section: Stem Cells: the Main Source Of Exosomes For Clinical Purpmentioning

confidence: 99%

Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology

Araldi

D’Amélio

Vigerelli

et al. 2020

Cells

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“…8 Therefore, dental pulp offers a biologic therapy option with benefits of minimally processed tissue, successful cryopreservation, high density of pluripotent cells, avoidance of on the farm processing and product variability, and lack of donor morbidity. Additionally, this promising tissue source of allogeneic stem or progenitor cells has been studied in human tissue and cells ( 33 , 39 – 48 ). The high concentration of human progenitor cells in un-erupted dental pulp resulted in robust harvest yields of undifferentiated cells that have been characterized ( 39 ).…”

Section: Introductionmentioning

confidence: 99%

“…The high concentration of human progenitor cells in un-erupted dental pulp resulted in robust harvest yields of undifferentiated cells that have been characterized ( 39 ). Dental pulp has recently served as a source of human pluripotent cells destined for differentiation into bone ( 40 – 42 ), blood vessels ( 43 , 44 ), ligament ( 45 ), and, uniquely, neural tissue ( 46 – 48 ) resulting in a menu of homologous applications. Human dental pulp has been expanded in culture or immediately cryopreserved and banked ( 33 ).…”

Section: Introductionmentioning

confidence: 99%

“…We predicted that dental pulp, minimally and mechanically processed, used as an injectable treatment for painful ST injury (tendonitis or desmitis) or OA, would affect those events associated with tissue injury (pain and inflammation) and result in less lameness. Growth factors within or stimulated by the dental pulp tissue treatment may also have the potential to prevent tissue degeneration and be disease-modifying ( 48 – 50 ).…”

Section: Introductionmentioning

confidence: 99%

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Equine Dental Pulp Connective Tissue Particles Reduced Lameness in Horses in a Controlled Clinical Trial

et al. 2017

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ObjectiveTo assess if injection of allogeneic dental pulp tissue particles would improve lameness in horses with naturally occurring osteoarthritis (OA) or soft tissue (ST) injury.DesignProspective, randomized, blinded, and controlled clinical trial and client survey assessment.AnimalsForty lame client-owned horses.ProceduresSterile dental pulp, recovered from otherwise healthy foals that perish during dystocia, was processed under good manufacturing processing to produce mechanically manipulated, unexpanded pulp tissue particles containing viable cells surrounded in extracellular matrix. Forty lame client-owned horses with confirmed OA (n = 20), or ST injury (desmitis or tendonitis) received a 2 mL intra-articular (n = 20 OA) or intra-lesional (n = 20) injection of control transport vehicle (n = 20) or 10 × 106 dental pulp tissue particles (n = 20). Acclimatized horses had baseline measurements performed and were then injected on day 0. Horses were treadmill exercised for 2 weeks, evaluated by clinical parameters, lameness score, edema (score and circumference), pain on flexion (OA) or pressure (ST), and clients’ scores for pain and discomfort before and through 45 days after pulp injection. Twenty horses were available for >2.5-year follow-up.ResultsPulp-treated horses showed decrease in lameness compared to baseline (P < 0.009) or placebo controls (P < 0.013) for at least 2 weeks. Client assessments of comfort were improved between before and 45 days after pulp injection (P < 0.001). Clinical improvement with ST injury was significantly greater than OA (P < 0.001). At >2.5-year follow-up, at least 10 horses were in work.Conclusion and clinical relevanceDental pulp tissue particles can be considered as a treatment option for equine lameness due to OA, desmitis, or tendonitis.

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Mesenchymal Stem Cells and Calcium Phosphate Bioceramics: Implications in Periodontal Bone Regeneration

Millán

Vivanco

Benjumeda-Wijnhoven

et al. 2018

Advances in Experimental Medicine and Biology

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In orthopedic medicine, a feasible reconstruction of bone structures remains one of the main challenges both for healthcare and for improvement of patients' quality of life. There is a growing interest in mesenchymal stem cells (MSCs) medical application, due to their multilineage differentiation potential, and tissue engineering integration to improve bone repair and regeneration. In this review we will describe the main characteristics of MSCs, such as osteogenesis, immunomodulation and antibacterial properties, key parameters to consider during bone repair strategies. Moreover, we describe the properties of calcium phosphate (CaP) bioceramics, which demonstrate to be useful tools in combination with MSCs, due to their biocompatibility, osseointegration and osteoconduction for bone repair and regeneration. Also, we overview the main characteristics of dental cavity MSCs, which are promising candidates, in combination with CaP bioceramics, for bone regeneration and tissue engineering. The understanding of MSCs biology and their interaction with CaP bioceramics and other biomaterials is critical for orthopedic surgical bone replacement, reconstruction and regeneration, which is an integrative and dynamic medical, scientific and bioengineering field of research and biotechnology.

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Dental pulp stem cells for treating neurodegenerative diseases

Cited by 9 publications

References 19 publications

Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology

Stem Cell-Derived Exosomes as Therapeutic Approach for Neurodegenerative Disorders: From Biology to Biotechnology

Equine Dental Pulp Connective Tissue Particles Reduced Lameness in Horses in a Controlled Clinical Trial

Mesenchymal Stem Cells and Calcium Phosphate Bioceramics: Implications in Periodontal Bone Regeneration

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