Dental problems associated with hypophosphataemic vitamin D resistant rickets

Goodman,; Gelbier,; Bennett, Malcolm J.; Winter, Andreas

doi:10.1046/j.1365-263x.1998.00059.x

Cited by 81 publications

(89 citation statements)

References 2 publications

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“…This phenomenon is associated with well documented oral and dental fi ndings 27,[30][31][32][33][34] . Hypophosphataemic vitamin D-resistant rickets have been atti ributed to the enlarged coronal pulp spaces and to the grossly defecti ve denti ne allowing ingress of micro-organism to the dental pulp once att riti on has removed the overlying protecti ve enamel 35,36 .…”

Section: Dental and Histologic Findingsmentioning

confidence: 98%

Types of Rickets, Dental and Histologic Findings: Review of the Literature

Tümen¹

2009

Pesq Bras Odontoped Clin Integr

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Introducti on: A disease that occurs during childhood, rickets is the failure of growing bone to mineralize. Many skeletal and radiographic changes can ocur because of the lack of calcifi ed osteoid and the buildup of unossifi ed carti lage. Proper bone formati on requires a complex interplay of several organs and chemicals, and vitamin D deserves special menti on because any disturbance in its producti on, absorpti on, or metabolism is paramount in the development of rickets. The pathophysiology of the disease is thought to be impaired phosphate transport, especially decreased phosphate resorpti on in the renal proximal tubule, as well as in the intesti ne. In most cases, the diagnosis is established with a thorough history and physical examinati on and confi rmed by laboratory evaluati on. Early diagnosis is essenti al because morbidity can be minimized if children are treated before eight months of age. Objecti ve: The aim of this literature review is to present various types of rickets with clinical features and the dental fi ndings, preventi ve measurements and treatments. Conclusion: The denti st as well as the pediatrician should be made aware of the features of this disorder so that early interventi on can prevent subsequent serious and more invasive dental procedures. KEYWORDS DESCRITORES Rickets;Hypophosphataemia; Oral manifestati ons; Therapeuti cs. RESUMO ABSTRACTIntrodução: O raquiti smo, uma doença que ocorre durante a infância, é a falta de crescimento ósseo necessário para a mineralização. Diversas alterações radiográfi cas esqueléti cas podem ocorrer devido a ausência de osteóide calcifi cado e a formação de carti lagem. A formação óssea adequada requer uma complexa interação de vários órgãos e produtos químicos, e a vitamina D merece uma menção especial, pois qualquer alteração na sua produção, absorção ou no seu metabolismo é fundamental para o desenvolvimento do raquiti smo. Acredita-se que a fi siopatologia da doença está no transporte inadequado do fosfato, especialmente na diminuição da reabsorção de fosfato no túbulo renal proximal bem como no intesti no. Na maioria dos casos, o diagnósti co é estabelecido com uma história completa e exame fí sico, e confi rmado por exames laboratoriais. O diagnósti co precoce é essencial, pois a morbidade pode ser minimizada se as crianças forem tratadas antes dos oito meses de idade. Objeti vo: Apresentar os vários ti pos de raquiti smo com suas característi cas clínicas, aspectos dentários, medidas preventi vas e tratamento. Conclusão: O cirurgião-denti sta, bem como o pediatra, devem ser informados das característi cas desta desordem para que a intervenção precoce possa evitar seqüelas subsequentes e procedimentos odontológicos mais invasivos.

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Section: Dental and Histologic Findingsmentioning

confidence: 98%

Types of Rickets, Dental and Histologic Findings: Review of the Literature

Tümen¹

2009

Pesq Bras Odontoped Clin Integr

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“…3). The affected teeth are characterised by a thin enamel layer [5,27,38,40,41,46] and dentinal defects [5,33,40,41,43,48] (Fig. 3).…”

Section: Search Of the Literaturementioning

confidence: 99%

“…3). Additionally, short roots [39,40,48] and root resorptions in primary dentition [37,48,49], poorly defined lamina dura [16,38,48,49] and hypoplastic alveolar ridge [16,48] are common findings.…”

Section: Search Of the Literaturementioning

confidence: 99%

Review of the dental implications of X-linked hypophosphataemic rickets (XLHR)

et al. 2015

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Objectives The aim of this article was to review the dental implications of X-linked hypophosphataemic rickets (XLHR) and to provide suggestions regarding the dental treatment of these patients. Materials and methods The following search items Bx-linked hypophosphataemia, hypophosphataemic rickets, vitamin Dresistant rickets^were used for literature search. Only full-text articles were analysed and summarized to get an overview of the different treatments and outcomes of hypophosphataemic patients. Results Radiographically, very large pulp chambers with an abnormally high pulp volume/tooth volume ratio, suggesting taurodontism, are often evident. The affected teeth are characterised by a thin enamel layer and dentinal defects. The gender distribution of hypophosphataemic patients is almost equal, but postpubertary males seem to show a trend to develop more severe dental symptoms of the disease. Abscesses without any signs of dental caries or trauma are frequent findings. The most often affected teeth are incisors followed by molars and premolars. Conclusions Treatment options include frequent dental examination, application of topical fluoride varnish and sealing of pits and fissures to prevent microbial invasion that may result in pulpitis and further endodontic complications. Clinical relevance X-linked hypophosphataemic rickets is associated with marked structural alterations of dental hard tissues and the development of multiple abscesses and sinus tracts of dental origin. Therefore, profound knowledge of the various dental implications of XLHR is required to provide these patients with the best possible treatment options.

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“…Usually males are affected to a greater extent, as would be expected of an X-dominant condition, and tend to show the most severe dental changes, including taurodontism. 53,56 The risks of an individual to dental abscess formation may be assessed by history and dental radiographic signs. 45 Usually, the younger the patient when the first abscesses occur, the more severe the dental manifestation.…”

Section: Familial Hypophosphataemic Rickets Clinical and Pathologicalmentioning

confidence: 99%