Dental plaque-inspired versatile nanosystem for caries prevention and tooth restoration

Xu, Yue; You, Yongning; Yi, Luyao; Wu, Xiaoyi; Zhao, Yaning; Yu, Jianming; Liu, He; Shen, Ya; Guo, Jingyi; Huang, Cui

doi:10.1016/j.bioactmat.2022.06.010

Cited by 33 publications

(40 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cariogenic bacteria adhering to the tooth surface and the subsequent formation of dental biofilms are major contributors to the occurrence and progression of caries [ 61 , 62 ]. Although tubule occlusion approaches could prevent the invasion of external bacteria and stimuli, continuous biofilm formation with acid production and reduced pH atmosphere is likely to compromise the sealing efficacy and induce re-exposure of dentin.…”

Section: Resultsmentioning

confidence: 99%

Epigallocatechin-3-gallate/mineralization precursors co-delivery hollow mesoporous nanosystem for synergistic manipulation of dentin exposure

Bian

Zhao

et al. 2023

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Epigallocatechin-3-gallate/mineralization precursors co-delivery hollow mesoporous nanosystem for synergistic manipulation of dentin exposure

Bian

Zhao

et al. 2023

Bioactive Materials

Self Cite

View full text Add to dashboard Cite

“…The most extensively used polymers in dendrimers in the dentistry field are polypropylene imine (PPI) and polyamidoamine (PAMAM). In dentistry, the dendrimers represent a promising tool for enhancing of mechanical properties of adhesives and resin structures as drug delivery platforms for antimicrobial drugs for the treatment of periodontal diseases and in peripheral dental implant areas and in dental biomaterials for biomimetic remineralization of enamel and dentin ( Table 3 ) [ 85 ].…”

Section: Drug Delivery Systems Used In the Prevention And Treatment O...mentioning

confidence: 99%

“…Xu and coworkers [ 85 ] successfully developed a dental plaque-inspired micellar nanosystem to treat caries and to act as a restorative biomaterial, encapsulating tannic acid (see anti-bacterial properties [ 111 , 112 ]) and sodium fluoride (NaF). After obtention, PMs were chemically conjugated to a salivary-acquired peptide (SAP), as a strategy to increase enamel adhesion.…”

Section: Drug Delivery Systems Used In the Prevention And Treatment O...mentioning

confidence: 99%

New Technological Approaches for Dental Caries Treatment: From Liquid Crystalline Systems to Nanocarriers

et al. 2023

View full text Add to dashboard Cite

Dental caries is the most common oral disease, with high prevalence rates in adolescents and low-income and lower-middle-income countries. This disease originates from acid production by bacteria, leading to demineralization of the dental enamel and the formation of cavities. The treatment of caries remains a global challenge and the development of effective drug delivery systems is a potential strategy. In this context, different drug delivery systems have been investigated to remove oral biofilms and remineralize dental enamel. For a successful application of these systems, it is necessary that they remain adhered to the surfaces of the teeth to allow enough time for the removal of biofilms and enamel remineralization, thus, the use of mucoadhesive systems is highly encouraged. Among the systems used for this purpose, liquid crystalline systems, polymer-based nanoparticles, lipid-based nanoparticles, and inorganic nanoparticles have demonstrated great potential for preventing and treating dental caries through their own antimicrobial and remineralization properties or through delivering drugs. Therefore, the present review addresses the main drug delivery systems investigated in the treatment and prevention of dental caries.

show abstract

“…In order to combat tooth decay and enhance enamel restoration, Xu et al. synthesized the micellars, 3-maleimidopropionic acid-poly(ethyleneglycol)-block-poly(L-lysine)/phyenylboronic acid (MAL-PEG-b-PLL/PBA), which contained pH-cleavable boronate ester bond ( Xu et al., 2022b ). The antibacterial agent tannic acid, NaF, and salivary-acquired peptide (SAP) were conjugated with MAL-PEG-b-PLL/PBA to form PMs@NaF-SAP.…”

Section: Ph-responsive Antibiofilm Strategiesmentioning

confidence: 99%

“…Dental caries start with the break of the oral eubiosis, shifting from commensal biofilm to cariogenic biofilm with abundant acidogenic and aciduric microbes ( Selwitz et al., 2007 ; Pitts et al., 2017 ; Tanner et al., 2018 ). There is a prolonged drop in pH value of cariogenic biofilm, leading to demineralization of dental hard tissue and development of dental caries when the value falls below 5.5 and lower ( Margolis et al., 1999 ; Selwitz et al., 2007 ; Pitts et al., 2017 ; Xu et al., 2022b ). Study confirmed that the pH at active caries niches was reduced to about 4.5 - 5.5 ( Bowen, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

pH-activated antibiofilm strategies for controlling dental caries

Wang

Li²,

Zhang³

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Dental biofilms are highly assembled microbial communities surrounded by an extracellular matrix, which protects the resident microbes. The microbes, including commensal bacteria and opportunistic pathogens, coexist with each other to maintain relative balance under healthy conditions. However, under hostile conditions such as sugar intake and poor oral care, biofilms can generate excessive acids. Prolonged low pH in biofilm increases proportions of acidogenic and aciduric microbes, which breaks the ecological equilibrium and finally causes dental caries. Given the complexity of oral microenvironment, controlling the acidic biofilms using antimicrobials that are activated at low pH could be a desirable approach to control dental caries. Therefore, recent researches have focused on designing novel kinds of pH-activated strategies, including pH-responsive antimicrobial agents and pH-sensitive drug delivery systems. These agents exert antibacterial properties only under low pH conditions, so they are able to disrupt acidic biofilms without breaking the neutral microenvironment and biodiversity in the mouth. The mechanisms of low pH activation are mainly based on protonation and deprotonation reactions, acids labile linkages, and H+-triggered reactive oxygen species production. This review summarized pH-activated antibiofilm strategies to control dental caries, concentrating on their effect, mechanisms of action, and biocompatibility, as well as the limitation of current research and the prospects for future study.

show abstract

Dental plaque-inspired versatile nanosystem for caries prevention and tooth restoration

Cited by 33 publications

References 62 publications

Epigallocatechin-3-gallate/mineralization precursors co-delivery hollow mesoporous nanosystem for synergistic manipulation of dentin exposure

Epigallocatechin-3-gallate/mineralization precursors co-delivery hollow mesoporous nanosystem for synergistic manipulation of dentin exposure

New Technological Approaches for Dental Caries Treatment: From Liquid Crystalline Systems to Nanocarriers

pH-activated antibiofilm strategies for controlling dental caries

Contact Info

Product

Resources

About