Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol‐containing chewing gum

Holgerson, Pernilla Lif; Sjöström, Inger; Stecksén‐Blicks, Christina; Twetman, Svante

doi:10.1111/j.1365-263x.2006.00808.x

Cited by 58 publications

(59 citation statements)

References 24 publications

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“…Three months after the end of the chewing period, no significant difference was found between the 2 groups. These results were expected, and reinforce previous findings [Mäkinen et al, 1989;Holgerson et al, 2007].…”

Section: Discussionsupporting

confidence: 83%

“…The interdental plaque pH was recorded in a group of children submitted to different xylitol chewing gum exposures. Previously, 6 g in a single dose was demonstrated to produce significantly less reduction in pH, after a sucrose 5% rinse, in comparison to a lower dosage [Holgerson et al, 2007]. The data from the present study show that xylitol chewing gum appears to be capable of producing a reduction in oral MS in children at high risk of caries.…”

Section: Discussionsupporting

confidence: 62%

“…The exact reason for the reduction in plaque acidogenicity was not evaluated in the present study, but can be attributed to several factors, such as change in number and virulence of cariogenic microorganisms, change in plaque composition or reduced plaque amount. In a sample of Sweden schoolchildren using a xylitol-containing chewing gum for 4 weeks, the amount of visible plaque and acid production were significantly reduced for children using xylitol as well as sorbitol and maltitol chewing gums, yet only the xylitol-containing gum produced a modification in microbial composition [Holgerson et al, 2007]. Therefore, the significantly lower plaque acidogenicity recorded in the xylitol group of the present study might be related to other factors.…”

Section: Discussionmentioning

confidence: 55%

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Six Months of Daily High-Dose Xylitol in High-Risk Schoolchildren: A Randomized Clinical Trial on Plaque pH and Salivary Mutans Streptococci

et al. 2009

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A randomized clinical trial was designed to evaluate the effect of daily high-dose xylitol chewing gum on plaque pH and salivary mutans streptococci (MS) in a sample of schoolchildren at high risk of caries. The study was performed on 204 subjects (acceptance rate 88.3%). Inclusion criteria were: >1 and <4 carious lesions, and a salivary MS concentration >10⁵ CFU/ml. Subjects were randomly assigned to the xylitol or control group. Study design included one examination at baseline (t₀), one after 3 months of chewing (t₁), one after 6 months of chewing (t₂) and the last 3 months after the end of chewing period (t₃). Plaque pH was assessed using the MicroTouch technique, following a sucrose challenge. The area under the curve (AUC_5.7 and AUC_6.2) was recorded. Whole saliva was collected in sterile vials and MS CFU/ml were counted. Data were analysed using repeated-measures ANOVA. The main result was that plaque acidogenicity was reduced in both groups. The differences between treatments were statistically significant both for plaque pH and MS concentration; the interaction term for treatment and time was statistically significant (p < 0.01). At t₂, the xylitol group children with a salivary MS concentration >10⁵ and those with ≤10⁵ showed significantly lower AUC_5.7 and AUC_6.2 values than the control group. These results suggest that the long-term use of high-dose non-sucrose chewing gums had beneficial effects on plaque pH, and that this effect was statistically greater when using xylitol chewing gums, both on plaque pH and MS salivary concentration.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 55%

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Six Months of Daily High-Dose Xylitol in High-Risk Schoolchildren: A Randomized Clinical Trial on Plaque pH and Salivary Mutans Streptococci

et al. 2009

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“…4,10,[26][27][28][29]31 However, xylitol also reduces both biofilm and S. mutans levels when added to a patients' diet as a sweetener, thus preventing early development of caries. 11,13,32,33 The results found in the present study corroborate these findings, since groups G1 (XYL) and G2 (CHX + XYL) showed enhanced reduction in biofilm levels in the sixth month compared to other groups (p <0.05).…”

Section: Discussionsupporting

confidence: 88%

Antimicrobial effects of the combination of chlorhexidine and xylitol

et al. 2010

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“…Ksilitol, sorbitol ya da maltitollü sakız çiğ-nenmesinin çürüklü ve çürüksüz olarak ayırılan 7-12 yaşındaki okul çocuklarında plak miktarı ve tükürük asit yapımını azalttığı; ancak sadece ksilitollü sakız (günlük dozu 6.18 g) çiğnemesi-nin MS ve total bakteri sayısında anlamlı azalmaya yol açtığı saptanmıştır (7) . Azalmanın çürüksüz çocuklarda daha belirgin olduğu bulunmuştur.…”

Section: Discussionunclassified

Effect of Chewing Xylitol Chewing Gum on Cariogenic Microorganisms

Topçuoğlu¹,

Çıftçı²,

Külekçi³

2012

ANKEM Derg

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ÖZET Bu çalışmanın amacı, on-on iki yaşlarındaki ilköğretim okulu öğrencilerinin piyasada satılan ksilitollü ve ksilitolsüz sakızları gözetim altında günde üç kez beş dakika olmak üzere dört hafta boyunca çiğnemeleri sonucu, tükürük mutans streptokokları (MS), laktobasil (LB) ve maya düzeyleri ile Streptococcus mutans ve Anahtar sözcükler: diş çürüğü, ksilitol, mutans streptokokları, sakız SUMMARY Effect of Chewing Xylitol Chewing Gum on Cariogenic Microorganisms The aim of this study was to investigate the effect of chewing gums with and without xylitol three times daily for 5 min on probation for 4 weeks, on salivary levels of mutans streptococci (MS), lactobacilli (LB) and yeast and the presence of Streptococcus mutans and Streptococcus sobrinus in primary school children at 10-12 years old.The study group was consisted of 29 students (mean age=10.6 years) among the 98 students whose salivary MS level was detected as >10 5 cfu/ml in a boarding primary school. After oral and dental examination, the group was randomly divided into three sub-groups as chewing the gum with xylitol (G1, n:12), chewing the gum without xylitol (G2, n:11) and chewing no gum (G3, n:6). G1 and G2 were chewed the gums three times daily for 4 weeks (5 days a week)

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Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol‐containing chewing gum

Abstract: The results suggest that chewing gum with xylitol or sorbitol/maltitol can reduce the amount of dental plaque and acid production in saliva in schoolchildren, but only the xylitol-containing gum may also interfere with the microbial composition.

Cited by 58 publications

References 24 publications

Six Months of Daily High-Dose Xylitol in High-Risk Schoolchildren: A Randomized Clinical Trial on Plaque pH and Salivary Mutans Streptococci

Six Months of Daily High-Dose Xylitol in High-Risk Schoolchildren: A Randomized Clinical Trial on Plaque pH and Salivary Mutans Streptococci

Antimicrobial effects of the combination of chlorhexidine and xylitol

Effect of Chewing Xylitol Chewing Gum on Cariogenic Microorganisms

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