Dental Medicine Nanosystems: Nanoparticles and their use in Dentistry and Oral Health Care

LBOUTOUNNE, Hassan

doi:10.25141/2471-657x-2017-10.0150

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…Nevertheless, as their highly demanded hydrophobic features cause certain incommodities (e.g., aggregation in aqueous media resulting in lower efficacy), introduction of nanosystems to the field of aPDT is a promising approach that can also combat biofilm-forming bacteria. 8,[456][457][458] The antimicrobial effectiveness using a nanosystem delivery is determined by its particle size, surface charge, and chemical composition causing interaction with the biofilm matrix and thereby greater retention leading to a higher efficacy. 459,460 Among others, the size of nanoparticles as well as its positive charge and hydrophobic nature have been found crucial for aPDT as there was described a deeper biofilm penetration by nanoparticles with these features leading to the increased antimicrobial efficacy when combined with a PS.…”

Section: Nanosystem Delivery In Antibacterial Pdtmentioning

confidence: 99%

“…As mentioned above, PSs with hydrophobic nature have been found to be the most effective in PDT and aPDT field. Nevertheless, as their highly demanded hydrophobic features cause certain incommodities (e.g., aggregation in aqueous media resulting in lower efficacy), introduction of nanosystems to the field of aPDT is a promising approach that can also combat biofilm‐forming bacteria 8,456–458 …”

Section: The Antibacterial Pdtmentioning

confidence: 99%

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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Kolarikova

Hošíková

Dilenko

et al. 2023

Medicinal Research Reviews

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Photodynamic therapy is an alternative treatment mainly for cancer but also for bacterial infections. This treatment dates back to 1900 when a German medical school graduate Oscar Raab found a photodynamic effect while doing research for his doctoral dissertation with Professor Hermann von Tappeiner. Unexpectedly, Raab revealed that the toxicity of acridine on paramecium depends on the intensity of light in his laboratory. Photodynamic therapy is therefore based on the administration of a photosensitizer with subsequent light irradiation within the absorption maxima of this substance followed by reactive oxygen species formation and finally cell death. Although this treatment is not a novelty, there is an endeavor for various modifications to the therapy. For example, selectivity and efficiency of the photosensitizer, as well as irradiation with various types of light sources are still being modified to improve final results of the photodynamic therapy. The main aim of this review is to summarize anticancer and antibacterial modifications, namely various compounds, approaches, and techniques, to enhance the effectiveness of photodynamic therapy.

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Section: Nanosystem Delivery In Antibacterial Pdtmentioning

confidence: 99%

Section: The Antibacterial Pdtmentioning

confidence: 99%

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Kolarikova

Hošíková

Dilenko

et al. 2023

Medicinal Research Reviews

View full text Add to dashboard Cite

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“…Materials in nano-size and drug-incorporated nanoparticles as well as their combination have found wide applications in dentistry for prevention, diagnosis, therapeutic, restoration, and tissue regeneration purposes [54,[123][124][125].…”

Section: Nanomaterials and Polymeric Nanoparticlesmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan²,

Akca

2021

Drug Deliv. and Transl. Res.

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Oral health reflects the general health, and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection-related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed, and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

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“…Nanomaterials and polymeric nanoparticles therapeutic, restoration and tissue regeneration purposes [52,[119][120][121].…”

Section: Micellesmentioning

confidence: 99%

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Şenel

Özdoğan

2021

Preprint

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Oral health reflects the general health and it is fundamental to well-being and quality of life. An infection in the oral cavity can be associated with serious complications in human health. Local therapy of these infections offers many advantages over systemic drug administration, targeting directly to the diseased area while minimizing systemic side effects. Specialized drug delivery systems into the oral cavity have to be designed in such a fashion that they resist to the aqueous environment that is constantly bathed in saliva and subject to mechanical forces. Additionally, a prolonged release of drug should also be provided, which would enhance the efficacy and also decrease the repeated dosing. This review is aimed to summarize the current most relevant findings related to local drug delivery of various drug groups for prevention and treatment of infections (viral, bacterial, fungal) and infection related manifestations in the oral cavity. Current therapeutic challenges in regard to effective local drug delivery systems will be discussed and the recent approaches to overcome these obstacles will be reviewed. Finally, future prospects will be overviewed to promote novel strategies that can be implemented in clinical management for prevention and treatment of oral infections.

show abstract

Dental Medicine Nanosystems: Nanoparticles and their use in Dentistry and Oral Health Care

Cited by 7 publications

References 4 publications

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

Current status and future of delivery systems for prevention and treatment of infections in the oral cavity

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