Dental Implants Loaded With Bioactive Agents Promote Osseointegration in Osteoporosis: A Review

Abstract

Implant-supported dentures are widely used in patients with defect or loss of dentition because these have higher chewing efficiency and do not damage the adjacent teeth compared with fixed or removable denture. An implant-supported denture carries the risk of failure in some systemic diseases, including osteoporosis, because of a non-ideal local microenvironment. Clinically common physical and chemical modifications are used to change the roughness of the implant surface to promote osseointegration, but they have limitations in promoting osteoinduction and inhibiting bone resorption. Recently, many researchers have focused on the study of bioactive modification of implants and have achieved promising results. Herein we have summarized the progress in bioactive modification strategy to promote osseointegration by regulating the local osteoporotic microenvironment.

Advances in Barrier Membranes for Guided Bone Regeneration Techniques

“…However, in recent years, rhBMP-9 has shown better osteogenic differentiation ability compared with rhBMP-2 ( Fujioka-Kobayashi et al, 2017 ). Another important growth factor, VEGF, is considered to be the most potent growth factor known to induce angiogenesis ( Zhang et al, 2021 ). It not only affects the differentiation of osteoblasts, but also plays an important role in cartilage resorption and promoting the early and late chondroossification of angiogenesis.…”

Therapeutic Treatments for Osteoporosis—Which Combination of Pills Is the Best among the Bad?

“…Here, some of the most important techniques should be briefly discussed. These methods are used in modern tissue engineering approaches for both scaffolds and drug release material manufacturing [228][229][230]. The following techniques are the best known: Both bulk and surface of the scaffolds can be tailored using certain fabrication methods.…”

Engineering Multifunctional Hydrogel With Osteogenic Capacity for Critical-Size Segmental Bone Defect Repair

“…The treatment of critical-size segmental bone defects caused by high-energy trauma, infection, revision arthroplasty, and after resection of bone tumor is one of the most challenging clinical issues, especially for patients with poor osteogenic capability ( Zhang et al, 2021 ; Li et al, 2022 ). Although autologous bone tissue possesses a certain self-healing capacity, it may still be insufficient under some special states such as critical-size segmental bone defects ( Russow et al, 2019 ).…”