Dental implant placement through impacted teeth or residual roots as an alternative to invasive extraction surgeries: a systematic literature review

Pérez-González, Fabian; Sánchez-Labrador, Luis; Molinero‐Mourelle, Pedro; Sáez-Alcaide, Luis Miguel; Cortés-Bretón-Brinkmann, Jorge; García-Denche, Jesús Torres; López-Quiles, Juan; Martı́nez-González, José Marı́a

doi:10.1016/j.bjoms.2020.12.018

Cited by 6 publications

(1 citation statement)

References 26 publications

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“…Within the last decade, a large variety of biomaterials have been developed, ranging from diagnostic tools [4] to dental [5] and orthopedic implants [6], organ replacement [7], Int. J. Mol.…”

Section: Introductionmentioning

confidence: 99%

Adhesion of Neurons and Glial Cells with Nanocolumnar TiN Films for Brain-Machine Interfaces

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Jahnke

et al. 2021

IJMS

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Coupling of cells to biomaterials is a prerequisite for most biomedical applications; e.g., neuroelectrodes can only stimulate brain tissue in vivo if the electric signal is transferred to neurons attached to the electrodes’ surface. Besides, cell survival in vitro also depends on the interaction of cells with the underlying substrate materials; in vitro assays such as multielectrode arrays determine cellular behavior by electrical coupling to the adherent cells. In our study, we investigated the interaction of neurons and glial cells with different electrode materials such as TiN and nanocolumnar TiN surfaces in contrast to gold and ITO substrates. Employing single-cell force spectroscopy, we quantified short-term interaction forces between neuron-like cells (SH-SY5Y cells) and glial cells (U-87 MG cells) for the different materials and contact times. Additionally, results were compared to the spreading dynamics of cells for different culture times as a function of the underlying substrate. The adhesion behavior of glial cells was almost independent of the biomaterial and the maximum growth areas were already seen after one day; however, adhesion dynamics of neurons relied on culture material and time. Neurons spread much better on TiN and nanocolumnar TiN and also formed more neurites after three days in culture. Our designed nanocolumnar TiN offers the possibility for building miniaturized microelectrode arrays for impedance spectroscopy without losing detection sensitivity due to a lowered self-impedance of the electrode. Hence, our results show that this biomaterial promotes adhesion and spreading of neurons and glial cells, which are important for many biomedical applications in vitro and in vivo.

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