“…Early-life events ( 49 ), medical condition ( 26 ), severe diseases during the period 0–3 years ( 58 ), and high frequency of pediatric disease ( 21 ) appear to be associated with aDDE. This may involve serious/chronic childhood diseases ( 11 , 14 , 59 ), such as the following factors cited in the literature: vitamin D deficiencies ( 17 ), hypocalcemia ( 60 ), chicken pox ( 61 ), infectious episodes ( 38 , 53 ), high fever ( 6 , 62 ), hospital admission ( 40 ), ear infection ( 27 , 63 ), renal disorders ( 64 ), liver failure/ liver transplant ( 65 ), thyroid dysfunction (both hypothyroidism and hyperthyroidism) ( 66 ), infantile eczema ( 33 ), tonsillectomy ( 67 ), intestinal disturbance [parasitic helminth infection ( 68 ) and pyloric spasm ( 63 ), celiac disease ( 69 , 70 ), vomiting and diarrhea ( 61 )], electric burns ( 71 ), idiopathic epilepsy ( 72 ), and the use of some drugs: antiretroviral therapy ( 24 ), antibiotic use ( 6 , 14 , 33 , 73 ), specifically penicillins ( 74 , 75 ) and cephalosporins ( 76 ).…”