Dental enamel defects and oral cavity manifestations in Asian patients with celiac disease

Ahmed, Anam; Singh, Alka; Kajal, Smile; Chauhan, Abhinavsingh; Rajput, Mahendra Singh; Banyal, Vikas; Ahuja, Vineet; Makharia, Govind

doi:10.1007/s12664-021-01175-7

Cited by 10 publications

(26 citation statements)

References 22 publications

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“…Conversely, the other seventeen studies [11,[20][21][22][23][24]26,30,31,33,34,36,[39][40][41][42]44] presented data indicating that the occurrence of RAS in the study group was statistically significantly higher when compared to the control group.…”

Section: Recurrent Aphthous Stomatitis (Ras)mentioning

confidence: 99%

“…The reviewed studies reported several other oral manifestations in patients with CD. Cheilitis, an inflammation of the lips, was reported in five of the studies [21,24,35,36,50], as detailed in Table 7. In the study by Ahmed et al [21], 13.6% (16/118) of CD patients had cheilosis/angular cheilitis, while none of the controls did.…”

Section: Other Oral Manifestationsmentioning

confidence: 99%

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Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease

Lucchese

Stasio

Stefano

et al. 2023

JCM

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Background: Celiac disease (CD) is a chronic immune-mediated gluten-sensitive enteropathy, affecting about 1% of the population. The most common symptoms include diarrhea, abdominal pain, weight loss, and malabsorption. Extra-intestinal symptoms include oral manifestations. This systematic review aims to catalog and characterize oral manifestations in patients with CD. Methods: a systematic literature review among different search engines using PICOS criteria has been performed. The studies included used the following criteria: tissues and anatomical structures of the oral cavity in humans, published in English and available in full text. Review articles and papers published before 1990 were excluded. Results: 209 articles were identified in the initial search. In the end, 33 articles met the selection criteria. The information extracted from the articles was classified based on the type of oral manifestation. Recurrent aphthous stomatitis (34.6%), atrophic glossitis and geographic tongue (15.26%), enamel defects (42.47%), delayed dental eruption (47.34%), xerostomia (38.05%), glossodynia (14.38%), and other manifestations including cheilitis, fissured tongue, periodontal diseases, and oral lichen planus were found in the celiac subjects of the studies analyzed. The quality of articles on the topic should be improved; however, oral manifestations in CD patients are widely described in the literature and could help diagnose celiac disease.

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Section: Recurrent Aphthous Stomatitis (Ras)mentioning

confidence: 99%

Section: Other Oral Manifestationsmentioning

confidence: 99%

Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease

Lucchese

Stasio

Stefano

et al. 2023

JCM

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“…В настоящее время широко признано, что целиакия может поражать полость рта и зубы, что проявляется в виде дефектов зубной эмали и рецидивирующих афтозных язв [20][21][22][23]. Оральные поражения при целиакии могут вызвать значительные функциональные и эстетические нарушения, а также ухудшить качество жизни пациента [4].…”

Section: специфические стоматологические проявления целиакииunclassified

Diseases of the oral mucosa and dental tissues as a manifestation of celiac disease

V.I.¹,

Gaydukova²,

Inamova³

et al. 2022

Russian Medical Inquiry

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Celiac disease, or gluten-sensitive enteropathy, is a chronic autoimmune disease characterized by immune response when taking gluten. Celiac disease is a multifactorial disorder that results from the interaction of genetic and environmental factors. The review examines the etiology and pathogenesis of celiac disease from the view of the oral mucosal lesions. Based on the data of medical literature sources, the analysis of the incidence, severity and structure of oral cavity changes in celiac disease was conducted. It has been shown that tooth enamel defects and recurrent aphthous stomatitis may be the only manifestation of celiac disease The most common oral cavity disorders in celiac disease are recurrent aphthous stomatitis, teething retention, tooth enamel defects, in particular hypoplasia. Angular cheilitis and atrophic glossitis are considered the very rare. The caries prevalence in patients diagnosed with celiac disease either does not differ from the prevalence in healthy patients, or the caries prevalence indices are significantly lower in patients with celiac disease than in the control group. Oral lesions in celiac disease can cause significant functional and aesthetic disorders, as well as worsen the patient’s life quality. KEYWORDS: celiac disease, gluten enteropathy, oral mucosa, caries, recurrent aphthous stomatitis, teething retention, cheilitis, atrophic glossitis FOR CITATION: Mazurov V.I., Gaydukova I.Z., Inamova O.V. et al. Diseases of the oral mucosa and dental tissues as a manifestation of celiac disease. Russian Medical Inquiry. 2022;6(8):451–457 (in Russ.). DOI: 10.32364/2587-6821-2022-6-8-451-457.

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Section: Introductionmentioning

confidence: 99%

“…Celiac disease (CD), a multifaceted autoimmune disorder triggered by the consumption of gluten in genetically susceptible individuals, presents an intricate interplay of systemic and localized manifestations ( Figure 1 ) [ 1 ]. This comprehensive exploration delves into the intricate correlation between celiac disease and dental enamel defects (DED), shedding light on pathophysiological mechanisms, oral health implications, and the critical role of dentists in early diagnosis [ 1 ]. As we navigate through the complexities of celiac disease and its impact on dental enamel, the importance of a systematic review becomes evident, aiming to consolidate existing knowledge, address diagnostic challenges, and empower dental practitioners in the identification of potential celiac patients [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Celiac Disease-Related Enamel Defects: A Systematic Review

Inchingolo,

Dipalma,

Viapiano

et al. 2024

JCM

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Introduction: This systematic review aims to elucidate the intricate correlation between celiac disease (CD) and dental enamel defects (DED), exploring pathophysiological mechanisms, oral health implications, and a dentist’s role in early diagnosis. Materials and methods: Following PRISMA guidelines, a comprehensive search from 1 January 2013 to 1 January 2024 across PubMed, Cochrane Library, Scopus, and Web of Science identified 153 publications. After exclusions, 18 studies met the inclusion criteria for qualitative analysis. Inclusion criteria involved study types (RCTs, RCCTs, case series), human participants, English language, and full-text available. Results: The search yielded 153 publications, with 18 studies meeting the inclusion criteria for qualitative analysis. Notable findings include a high prevalence of DED in CD patients, ranging from 50 to 94.1%. Symmetrical and chronological defects, according to Aine’s classification, were predominant, and significant associations were observed between CD severity and enamel defect extent. Conclusions: The early recognition of oral lesions, particularly through Aine’s classification, may signal potential CD even in the absence of gastrointestinal symptoms. Correlations between CD and dental health conditions like molar incisor hypomineralization (MIH) emphasize the dentist’s crucial role in early diagnosis. Collaboration between dentists and gastroenterologists is essential for effective monitoring and management. This review consolidates current knowledge, laying the groundwork for future research and promoting interdisciplinary collaboration for improved CD-related oral health outcomes. Further large-scale prospective research is recommended to deepen our understanding of these issues.

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Dental enamel defects and oral cavity manifestations in Asian patients with celiac disease

Cited by 10 publications

References 22 publications

Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease

Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease

Diseases of the oral mucosa and dental tissues as a manifestation of celiac disease

Celiac Disease-Related Enamel Defects: A Systematic Review

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