DENTAL DISEASE | Etiology of Dental Caries

Duggal, M. S.; Curson, M.E.J.

doi:10.1016/b0-12-227055-x/00325-4

Cited by 3 publications

(1 citation statement)

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“…To the best of our knowledge, no previous research studied the antibacterial effect of remineralizing agents against commensal oral bacteria. Philip et al [34] stated that actinomyces were considered as anaerobic, nonvirulent commensal bacteria that were normally found in the oropharynx and gastrointestinal tract as a resident microbial flora. Actinomyces viscosus was one of the clinically relevant species.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antibacterial Activity and the Remineralizing Potentiality of Two Natural Extracts and Their Mixture (In Vitro Study)

Saleh

Nagi

Elgamily

et al. 2022

Open Access Maced J Med Sci

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AIM: This study aimed to assess the antibacterial activity against the cariogenic Streptococcus mutans (ATCC 25175) and the commensal Actinomyces viscous (1300 EMCCN) oral bacteria and to determine the remineralizing effect of the previously demineralized bovine enamel lesion of ginger extract, eggshell extract as well as their mixture. METHODS: The two different extracts; eggshell extract and ginger extract were prepared as well as their mixture in an equal volume. Their antibacterial activity against S. mutans and A. viscous was assessed by well diffusion test and clear zones diameters measurement (mm). Chlorhexidine and Dimethyl sulfoxide solution were utilized as positive and negative control, respectively. Thirty-six anterior bovine teeth were subjected to artificial caries pH cycling regimen including alternate demineralization and remineralization for 5 days. Then they were randomly divided into three groups (G) (n = 12): G1: Ginger, G2: Eggshell, and G3: Mixture. Specimens of each group were separately immersed in 50 ml of the tested extract for 12 h seven successive days. Vickers Microhardness and Energy Dispersive X-ray (EDX) Analysis were assessed at baseline, after demineralization and remineralization. RESULTS: Both extracts had antibacterial effect against the profile growth of S. mutants. However, the mixture showed the highest statistically significant mean inhibition zone diameters (mm), followed by ginger and eggshell extracts with no statistically significant difference between them. Regarding the remineralizing efficacy; G1:(Ginger) group showed the highest statistically significant mean microhardness followed by G3:(Mixture) group, then eggshell treated specimens; which showed the least statistically significant mean microhardness values. Regarding EDIX analysis results, a statistically significant increase in F (wt%) after remineralization in both eggshell and ginger treated specimens. CONCLUSION: Ginger as well as mixture extracts not only have antibacterial effect against cariogenic bacteria but also have a strong remineralizing ability of demineralized enamel.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Antibacterial Activity and the Remineralizing Potentiality of Two Natural Extracts and Their Mixture (In Vitro Study)

Saleh

Nagi

Elgamily

et al. 2022

Open Access Maced J Med Sci

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Blue light photoinhibition of Streptococcus mutans: potential chromophores and mechanisms

Mohamad,

Megson,

Kean

2023

Laser Dent Sci

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The direct application of blue light (λ = 400–500 nm) provides a promising antimicrobial modality, the effects of which are mediated through generation of reactive oxygen species. Porphyrins are organic compounds essential for bacterial synthesis of heme and are understood to be the main blue light chromophores within bacteria, which are critical to the sensitivity to blue light. However, Streptococcus mutans — the principal etiological species of dental caries — has shown susceptibility towards blue light despite reportedly lacking heme synthesis pathways, raising a question as to how this susceptibility is mediated. S. mutans lacks heme-containing cytochromes for full aerobic respiration, instead relying mainly on flavin adenine dinucleotide enzymes for oxygen-dependent metabolism. This review article investigates the potential target chromophores and mechanisms underpinning the inhibitory effects of blue light in S. mutans. Multiple reports support the proposition that bacteria with blocked heme synthetic pathways still possess the genetic antecedents capable of generating porphyrins and heme proteins under appropriate conditions. Blue light is absorbed by flavins, and hence, the flavoenzymes also represent potential chromophores. In conclusion, depending on in-vitro growth and metabolic conditions, there is more than one blue light chromophore within S. mutans. To optimise clinical application of blue light-induced antimicrobial effects, future investigations should focus on in-vivo models and clinical trials.

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Farmers from southwestern Carpathian Basin: Neolithic lifeways in the light of new radiocarbon and stable isotope evidence from the sites of Golokut Vizić, Donja Branjevina, and Bezdan-Bački Monoštor in northern Serbia

Jovanović,

Blagojević,

Marković

et al. 2024

Journal of Archaeological Science: Reports

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DENTAL DISEASE | Etiology of Dental Caries

Cited by 3 publications

References 0 publications

Evaluation of the Antibacterial Activity and the Remineralizing Potentiality of Two Natural Extracts and Their Mixture (In Vitro Study)

Evaluation of the Antibacterial Activity and the Remineralizing Potentiality of Two Natural Extracts and Their Mixture (In Vitro Study)

Blue light photoinhibition of Streptococcus mutans: potential chromophores and mechanisms

Farmers from southwestern Carpathian Basin: Neolithic lifeways in the light of new radiocarbon and stable isotope evidence from the sites of Golokut Vizić, Donja Branjevina, and Bezdan-Bački Monoštor in northern Serbia

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