Dental abnormalities in children treated for acute lymphoblastic leukemia

Kaste, Sue C.; Hopkins, Kenneth P.; Jones, Dana; Crom, Deborah B.; Greenwald, Carol; Santana, Víctor M.

doi:10.1038/sj.leu.2400670

Cited by 95 publications

(128 citation statements)

References 1 publication

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“…[13][14][15][16]24,25 The known long-term effects associated with chemotherapy include agenesis, microdontia, root stunting, enamel hypoplasia, and alteration of facial growth, taurodontia, over-retention of primary teeth, and an increased caries index in survivors of childhood cancer. [13][14][15][16] Impaired root development decreases the growth of alveolar bone, thus impairing the vertical development of the mandible and the lower third of the face. 17 Other reported adverse sequelae include malocclusion, 18 narrowing of the pulp canal, 19 and reduced temporomandibular joint mobility.…”

Section: Discussionmentioning

confidence: 99%

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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Summary:The purpose of our study was to describe the types and frequencies of altered dental development in pediatric patients preparing for bone marrow transplantation (BMT). Retrospective review of the medical records and panoramic radiographs of all patients who underwent BMT at St Jude Children's Research Hospital between 1990 and 2000 for whom pre-BMT dental examination and panoramic radiography records were available. All patients were treated on institutional protocols. We recorded patient demographics and radiographic evidence of microdontia, hypodontia, taurodontia, root stunting, caries, enamel pearls, and pulpal calcifications. The 259 patients identified (150 male and 109 female) had a median age of 12.82 years (range, 3.18-25.93 years) at the time of BMT. In total, 203 were Caucasian, 38 were African-American, and 18 were of other races. In all, 150 (57.9%) had abnormal dentition. The most common dental abnormalities were caries (n ¼ 84), pulpal calcifications (n ¼ 34), and dental extractions (n ¼ 33). Developmental abnormalities occurred less frequently: taurodontia (n ¼ 8), hypodontia (n ¼ 10), microdontia (n ¼ 11), and root stunting (n ¼ 11). Dental abnormalities are prevalent in children undergoing BMT. Pre-transplant oral hygiene and dental examination should be standard care in order to minimize potential sites of infection.

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Section: Discussionmentioning

confidence: 99%

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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“…[3][4][5][6] These late effects potentially include secondary neoplasms; pulmonary effects; cardiovascular effects including anthracyclineinduced cardiomyopathy, ischemic heart disease, and obesity; osteopenia and osteoporosis; endocrine disorders including growth hormone deficiency and thyroid disease; cognitive dysfunction; and dental and periodontal disease. [7][8][9][10][11][12][13][14][15] The potential of being afflicted by these late health effects emphasizes the need for preventive health practices among childhood cancer survivors. Because recurrent or secondary tumors will have such a profound impact on a survivor's health, cancer screening is of particular importance.…”

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confidence: 99%

The cancer screening practices of adult survivors of childhood cancer

Yeazel

Oeffinger

Gurney

et al. 2004

Cancer

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BACKGROUNDThe current study characterized the self‐reported cancer screening practices of adult survivors of childhood cancer.METHODSA cohort of 9434 long‐term survivors of childhood cancer and a comparison group of 2667 siblings completed a 289‐item survey that included items regarding cancer‐screening practices.RESULTSOverall, 27.3% of female respondents reported performing breast self‐examination (BSE) regularly, 78.2% reported undergoing a Papanicolaou smear within the previous 3 years, 62.4% underwent a clinical breast examination (CBE) within the last year, and 20.9% had gotten a mammogram at least once in their lifetime. Approximately 17.4% of male respondents reported performing regular testicular self‐examination (TSE). Women age ≥ 30 years who had been exposed to chest or mantle radiation therapy were more likely to report undergoing CBE (odds ratio [OR], 1.59; 95% confidence interval [95% CI], 1.32–1.92) and mammography (OR, 1.92; 95% CI, 1.47–2.56). Compared with the sibling comparison group, survivors demonstrated an increased likelihood of performing TSE (OR, 1.52; 95% CI, 1.22–1.85) or BSE (OR, 1.30; 95% CI, 1.10–1.52), of having undergone a CBE within the last year (OR, 1.18; 95% CI, 1.02–1.35), and of ever having undergone a mammogram (OR, 1.82; 95% CI, 1.52–2.17).CONCLUSIONSThe results of the current study demonstrate that the cancer screening practices among survivors of childhood cancer are below optimal levels. Primary care physicians who include childhood cancer survivors among their patients could benefit these individuals by informing them about future cancer risks and recommending appropriate evidence‐based screening. Cancer 2004. © 2003 American Cancer Society.

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“…Hypodontia, microdontia, enamel hypoplasia, root stunting, taurodontia, over-retention of primary teeth, and an increased caries index have been reported in survivors of childhood cancer. [10][11][12][13] Impaired root development reduces the growth of alveolar bone, which adversely affects the subsequent vertical development of the mandible and the lower one-third of the face. 14 Other reported abnormalities include malocclusion, 15 narrowing of the pulp canal, 16 and decreased temporomandibular joint mobility.…”

mentioning

confidence: 99%

Dental abnormalities after pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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Summary:Our purpose was to describe the types and frequencies of altered dental development in pediatric patients following bone marrow transplantation (BMT). A retrospective review of the medical records and panoramic radiographs of all patients who underwent BMT at St Jude Children's Research Hospital between 1990 and 2000, for whom pre-BMT and post-BMT dental examination and panoramic radiography records were available, is presented. All patients were treated on institutional protocols. We recorded patient demographics and radiographic evidence of microdontia, hypodontia, taurodontia, root stunting, caries, enamel pearls, dental restorations/extractions and pulpal calcification. The 99 patients identified (52 males, 47 females) had a median age of 13.5 years (range, 3.4-25.9 years) at the time of BMT. In all, 73 were Caucasian, 15 were African-American, and 11 were of other races. The frequency of radiographically evident root stunting in permanent teeth was significantly increased after BMT (Po0.001), but there was no significant change in the frequency of other dental abnormalities after BMT. Dental abnormalities are prevalent in survivors of childhood BMT, but only root stunting appeared to progress with BMT. Bone Marrow Transplantation (2005) 36, 725-729.

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Dental abnormalities in children treated for acute lymphoblastic leukemia

Cited by 95 publications

References 1 publication

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Dental abnormalities in children preparing for pediatric bone marrow transplantation

The cancer screening practices of adult survivors of childhood cancer

Dental abnormalities after pediatric bone marrow transplantation

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