Dental abnormalities associated with familial expansile osteolysis: A clinical and radiographic study

Mitchell, Christina A.; Kennedy, John G.; Wallace, R. G. H.

doi:10.1016/0030-4220(90)90145-i

Cited by 28 publications

(21 citation statements)

References 10 publications

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“…Surprisingly, no impact on the immune system has been reported to date. Early tooth loss was also observed in some cases associated with idiopathic external resorption, localized at either the apical or cervical levels (Mitchell et al, 1990; Hughes et al, 1994; Whyte, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, these diseases are characterized by uncontrolled bone remodeling, with the presence of many and often enlarged osteoclasts, accompanied by areas of active bone formation. Premature permanent tooth loss and root external resorption have been described in these pathologies as consequences of the increased osteoclast activity (Mitchell et al, 1990; Nakatsuka et al, 2003). However, a fine analysis of growth alterations of the complex formed by tooth and alveolar bone has, so far, not been done.…”

mentioning

confidence: 99%

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Bone resorption control of tooth eruption and root morphogenesis: Involvement of the receptor activator of NF‐κB (RANK)

Castañeda

Simon

Jacques

et al. 2010

Journal Cellular Physiology

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Activation of the receptor activator of NF-κB (RANK) is a crucial step in osteoclastogenesis. Loss- and gain-of-function mutations in the Rank gene cause, respectively, osteopetrosis and several forms of extensive osteolysis. Tooth and alveolar bone alterations are associated with these pathologies but remain to be better characterized. The aim of the present study was to establish the tooth and alveolar bone phenotype of a transgenic mouse model of RANK over-expression in osteoclast precursors. Early tooth eruption and accelerated tooth root elongation were observed subsequent to an increase in osteoclast numbers surrounding the tooth. The final root length appeared not to be affected by RANK over-expression, but a significant reduction in root diameter occurred in both control and root-morphogenesis-defective Msx2 null mutant mice. These results indicate that root length is independent of the surrounding bone resorption activity. In contrast, root diameter is sensitive to the activity of alveolar bone osteoclasts. These data suggest that early eruption and thin root are phenotypic features that could be associated with extensive osteolytic pathologies.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Bone resorption control of tooth eruption and root morphogenesis: Involvement of the receptor activator of NF‐κB (RANK)

Castañeda

Simon

Jacques

et al. 2010

Journal Cellular Physiology

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“…Familial expansile osteolysis (FEO) was first described in a family from Northern Ireland and is inherited as an autosomal dominant trait [87][88][89][90][91]. The disease becomes manifest in the second decade and is characterized by osteoclastic resorption with cancellous bone expansion and elevation in serum alkaline phosphatase.…”

Section: Osteitis Deformans (Paget Disease)mentioning

confidence: 99%

Benign Fibro-Osseous Lesions of the Craniofacial Complex A Review

Eversole

El‐Mofty

2008

Head and Neck Pathol

276

357

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Benign fibro-osseous lesions of the craniofacial complex are represented by a variety of disease processes that are characterized by pathologic ossifications and calcifications in association with a hypercellular fibroblastic marrow element. The current classification includes neoplasms, developmental dysplastic lesions and inflammatory/reactive processes. The definitive diagnosis can rarely be rendered on the basis of histopathologic features alone; rather, procurement of a final diagnosis is usually dependent upon assessment of microscopic, clinical and imaging features together. Fibrous dysplasia and osteitis deformans constitute two dysplastic lesions in which mutations have been uncovered. Other dysplastic bone diseases of the craniofacial complex include florid osseous dysplasia, focal cemento-osseous dysplasia and periapical cemental dysplasia, all showing a predilection for African descent individuals; although no specific genetic alterations in DNA coding have yet to be uncovered and most studies have been derived from predominant high African descent populations. Ossifying fibromas are neoplastic lesions with four subtypes varying with regard to behavior and propensity for recurrence after surgical excision. The clinicopathologic and molecular features of this unique yet heterogeneous group of diseases are reviewed.

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“…Idiopathic resorption in multiple roots is far rare than the resorption seen in one or two teeth and occurs in a pattern completely different from that seen in physiologic resorption. The authors have theorized on causes such as microbiologically induced osteoclastic (13) or chronic inflammatory activity (14), familial disorders (15, 16), occlusal trauma (17), orthodontic movement (14), systemic disorders or drug use (18). Although infrequently reported, two types of idiopathic root resorption have been observed: apical and cervical (17).…”

Section: Reported Cases Of Idiopathic Multiple External Root Resorptmentioning

confidence: 99%

Idiopathic root resorption of the entire permanent dentition: systematic review and report of a case

Soğur

Akdeniz³

et al. 2008

Dental Traumatology

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A rare case of idiopathic root resorption affecting the entire dentition was described. Root resorptions of all of the maxillary and mandibular teeth were coincidentally diagnosed on patient's radiographic examination. The patient's medical and dental findings were non-contributory, other than the increased mobility of upper incisors. No significant familial findings could be identified. Detailed radiographic examination revealed resorption affecting the apical part of the roots, resulting in vertical shortening of the teeth. The character of the resorption was as if a tapering occurred throughout the lateral root surfaces. Involved teeth were endodontically treated and the patient was subsequently followed-up for 18 months. Following endodontic therapy, all periapical lesions demonstrated clinical and radiographic evidence of healing. Endodontic therapy resulted in a high degree of success to stop resorption process and maintain the dentition.

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Dental abnormalities associated with familial expansile osteolysis: A clinical and radiographic study

Cited by 28 publications

References 10 publications

Bone resorption control of tooth eruption and root morphogenesis: Involvement of the receptor activator of NF‐κB (RANK)

Bone resorption control of tooth eruption and root morphogenesis: Involvement of the receptor activator of NF‐κB (RANK)

Benign Fibro-Osseous Lesions of the Craniofacial Complex A Review

Idiopathic root resorption of the entire permanent dentition: systematic review and report of a case

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