Understanding the nucleon-nucleon () interaction is a fundamental task in nuclear physics, as -interaction models are a crucial input to modern nuclear structure calculations. While great progress has been made toward understanding this interaction, the available state-of-the-art models predict significantly different behaviors at short distances and high momenta (scale-and-scheme dependence), where two-nucleon Short-Range Correlations (SRCs) dominate the nuclear wave function. Thus, SRCs are a unique tool to constrain the interaction and vice versa. SRCs are naturallyoccurring high-local-density pairs that, as a result of their short-distance ( 1 fm) repulsive interaction, fly apart with high momenta, hence populating momentum states above the Fermi level ( ≈ 250 MeV/ ). The study of SRCs also has significant implications for other fields, such as the astrophysics of neutron stars and the behavior of cold atomic gasses. This thesis describes experimental and phenomenological studies of the short-distance / high-momentum structure of the interaction through the study of SRCs and vice versa. Experimentally, I report the first measurement of the 3 He and 3 H( , ′ ) reactions in Hall A of the Thomas Jefferson National Accelerator Facility in kinematics in which the measured cross sections should be sensitive to the underlying nucleon momentum distributions in the range 40 to 500 MeV/ . The resulting cross-section ratios and absolute cross sections were compared to momentum-distribution ratios and precise cross-section calculations respectively. Phenomenologically, I report the generalization of the Contact Formalism (GCF) to nuclear systems, which exploits scale separation and universality to describe nucleons at short distances and high momenta.