Densitometric, tomographic and mechanical parameters of the female Wistar rat skeletal system after lactoferrin and colostrum treatment in the condition of gonadectomy-induced osteopenia

Pharmacological and Non-Pharmacological Agents versus Bovine Colostrum Supplementation for the Management of Bone Health Using an Osteoporosis-Induced Rat Model

“…It is believed that the positive effects on bone induced by BC occur mainly due to some of its constituents [ 23 , 24 , 25 , 26 ], especially the lactoferrin [ 22 ]. Bone anabolic effects of lactoferrin have been well studied and established by several in vitro [ 28 , 42 , 43 ] and in vivo studies performed in mice [ 43 , 44 ], rats [ 37 , 45 , 46 ], and in postmenopausal women [ 47 ]. Nevertheless, although positive effects of BC on bone metabolism have been reported, the question remains as to whether BC could be used as a supplement to manage osteoporosis.…”

Bovine Colostrum Supplementation Improves Bone Metabolism in an Osteoporosis-Induced Animal Model

“…In vitro studies have shown that LF stimulates osteoblast differentiation and proliferation [ 41 , 42 , 55 , 56 ] and decreases osteoblast apoptosis [ 57 ]. Moreover, it has been shown that LF also inhibits differentiation of osteoclasts [ 41 , 58 , 59 ] and reduces their resorbing activity [ 47 , 52 , 58 , 60 , 61 , 62 , 63 ]. In vivo, oral administration of LF has been shown to improve bone mass, microarchitecture, biomechanical, and strength parameters in OVX mice [ 58 , 62 ] and rats [ 47 , 52 , 61 ].…”

“…Moreover, it has been shown that LF also inhibits differentiation of osteoclasts [ 41 , 58 , 59 ] and reduces their resorbing activity [ 47 , 52 , 58 , 60 , 61 , 62 , 63 ]. In vivo, oral administration of LF has been shown to improve bone mass, microarchitecture, biomechanical, and strength parameters in OVX mice [ 58 , 62 ] and rats [ 47 , 52 , 61 ]. In a randomized controlled trial, postmenopausal women receiving an RNA-se enriched LF supplementation improved bone-specific formation markers (ALP increased by 45% and OC by 16%), while reducing bone-specific resorption markers (urine D-Pyr decreased by 14%) [ 63 ].…”