The surface tension and wettability of liquid Fe-16 mass%Cr-S alloy with alumina substrate at 1823 K and the temperature dependence of surface tension of liquid Fe-16 mass% Cr-S alloy in the temperature range of 1808-1883 K were measured using the sessile drop technique. The surface tension and contact angle of liquid Fe-16 mass%Cr-S alloys with alumina substrate decreased markedly with increasing sulphur concentration in the alloys. The variation of surface tension of liquid Fe-16 mass% Cr-S alloys with sulphur activity can be described by the following equation: ' 1g ¼ 1640 À 182 lnð1 þ 157a S Þ (mass% O=0.0037-0.0075, mass% S 0.195) (mN/m). The interfacial tension between liquid Fe-16 mass% Cr-S alloys and alumina substrate, calculated using Young's equation, can be expressed by the following equation: ' s1 ¼ 2170 À 220 lnð1 þ 237a S Þ (mass% O=0.0037-0.0075, mass% S 0.195) (mN/m). The work of adhesion between liquid Fe-16 mass% Cr-S alloys and alumina had a tendency to increase with increasing sulphur concentration. The temperature coefficient of surface tension, d'=dT, for Fe-16 mass% Cr-S system in the temperature range of 1808-1883 K increased with increasing sulphur concentration, and changed from negative to positive value when the sulphur concentration exceeded 20 mass ppm.