Densified collagen tubular grafts for human tissue replacement and disease modelling applications

Justin, Alexander W.; Cammarata, Federico; Guy, Andrew A.; Estevez, Silas R.; Burgess, Sebastian; Davaapil, Hongorzul; Stavropoulou-Tatla, Agavi; Ong, John; Jacob, Aishwarya G.; Saeb‐Parsy, Kourosh; Sinha, Sanjay; Markaki, Athina E.

doi:10.1016/j.bioadv.2022.213245

Cited by 2 publications

(2 citation statements)

References 61 publications

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“…This strategy allowed customizable collagen constructs with superior mechanical properties and stability, due to densification, to be obtained. Moreover, they showed that the method and densified collagen was adequate for cell culture, allowing high concentration cellularization with different cell lines [ 109 ].…”

Section: Natural Biomaterials For Vascular Tissue Engineeringmentioning

confidence: 99%

Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Di Francesco,

Pigliafreddo,

Casarella

et al. 2023

Biomolecules

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The clinical demand for tissue-engineered vascular grafts is still rising, and there are many challenges that need to be overcome, in particular, to obtain functional small-diameter grafts. The many advances made in cell culture, biomaterials, manufacturing techniques, and tissue engineering methods have led to various promising solutions for vascular graft production, with available options able to recapitulate both biological and mechanical properties of native blood vessels. Due to the rising interest in materials with bioactive potentials, materials from natural sources have also recently gained more attention for vascular tissue engineering, and new strategies have been developed to solve the disadvantages related to their use. In this review, the progress made in tissue-engineered vascular graft production is discussed. We highlight, in particular, the use of natural materials as scaffolds for vascular tissue engineering.

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Section: Natural Biomaterials For Vascular Tissue Engineeringmentioning

confidence: 99%

Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Di Francesco,

Pigliafreddo,

Casarella

et al. 2023

Biomolecules

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“…Most tubular scaffolds fail to reach the concentration of ColI in native tissues. To address this issue, Justin et al developed a densification method that generates a new type of highly concentrated collagenous tubular materials259 . The resulting tubes are seamless, provided with relevant mechanical properties and display homogeneous fibril density along the tube.…”

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confidence: 99%

Biomimetic materials to replace tubular tissues

Martinier,

Trichet,

Fernandes

2024

Preprint

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Repairing tubular tissues—the trachea, the esophagus, urinary and gastrointestinal tracts, and the circulatory system—from trauma or severe pathologies that require resection, calls for new, more effective graft materials. Currently, the relatively narrow family of materials available for these applications relies on synthetic polymers that fail to reproduce the biological and physical cues found in native tissues. Mimicking the structure and the composition of native tubular tissues to elaborate functional grafts is expected to outperform the materials currently in use, but remains one of the most challenging goals in the field of biomaterials. Despite their apparent diversity, tubular tissues share extensive compositional and structural features. Here, we assess the current state of the art through a dual layer model, reducing each tissue to an inner epithelial layer and an outer muscular layer. Based on this model, we examine the current strategies developed to mimic each layer and we underline how each fabrication method stands in providing a biomimetic material for future clinical translation. The analysis provided here, addressed to materials chemists, biomaterials engineers and clinical staff alike, sets new guidelines to foster the elaboration of new biomimetic materials for effective tubular tissue repair.

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Densified collagen tubular grafts for human tissue replacement and disease modelling applications

Cited by 2 publications

References 61 publications

Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Biomimetic materials to replace tubular tissues

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