Dense nanolipid fluid dispersions comprising ibuprofen: Single step extrusion process and drug properties

Morrison, Eric D.; Guo, Min; Maia, João M.; Nelson, Daniel A.; Swaminathan, Suresh Kumar; Kandimalla, Karunya K.; Lee, Han Seung; Zasadzinski, Joseph A.; McCormick, Alon V.; Marti, James; Garhofer, Brian

doi:10.1016/j.ijpharm.2021.120289

Cited by 2 publications

(1 citation statement)

References 56 publications

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“…The study mainly focused on the fabrication of DNLF dispersions and the mechanism of DNLF for enhanced transdermal delivery was not explored. In vitro and in vivo efficacy evaluations were also absent (Morrison et al, 2021). Flurbiprofen has also been delivered by nanolipids.…”

Section: Transdermal Delivery Of Nanomedicines For Arthritic Injuriesmentioning

confidence: 99%

Recent advances on transdermal delivery systems for the treatment of arthritic injuries: From classical treatment to nanomedicines

Shang

Younas

Zhang

2022

WIREs Nanomed Nanobiotechnol

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Arthritic injuries happen frequently during a lifetime due to accidents, sports, aging, diseases, etc. Such injuries can be cartilage/bone injuries, tendon injuries, ligament injuries, inflammation, pain, and/or synovitis. Oral and injective administration of therapeutics are typically used but cause many side effects. Transdermal administration is an alternative route for safe and efficient delivery. Transdermal formulations of non-steroidal anti-inflammatory drugs have been available on market for years and show promising efficacy in pain relieving, inflammation alleviation, infection control, and so on. Innovative transdermal patches, gels/films, and microneedles have also been widely explored as formulations to deliver therapeutics to combat arthritic injuries. However, transdermal formulations that halt disease progression and promote damage repair are translated slowly from lab bench to clinical applications. One major reason is that the skin barrier and synovial capsule barrier limit the efficacy of transdermal delivery. Recently, many nanocarriers, such as nanoparticles, nanolipids, nanoemulsions, nanocrystals, exosomes, etc., have been incorporated into transdermal formulations to advance drug delivery. The combined transdermal formulations show promising safety and efficacy.Therefore, this review will focus on stating the current development of nanomedicine-based transdermal formulations for the treatment of arthritic injuries. The advances, limitations, and future perspectives in this field will also be provided to inspire future studies and accelerate clinical translational studies.

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Section: Transdermal Delivery Of Nanomedicines For Arthritic Injuriesmentioning

confidence: 99%

Recent advances on transdermal delivery systems for the treatment of arthritic injuries: From classical treatment to nanomedicines

Shang

Younas

Zhang

2022

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

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Current analytical approaches for characterizing nanoparticle sizes in pharmaceutical research

Chaturvedi,

Maheshwari,

Chawathe

et al. 2024

J Nanopart Res

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Dense nanolipid fluid dispersions comprising ibuprofen: Single step extrusion process and drug properties

Cited by 2 publications

References 56 publications

Recent advances on transdermal delivery systems for the treatment of arthritic injuries: From classical treatment to nanomedicines

Recent advances on transdermal delivery systems for the treatment of arthritic injuries: From classical treatment to nanomedicines

Current analytical approaches for characterizing nanoparticle sizes in pharmaceutical research

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