Dense drug-eluting biodegradable Fe-Ag nanocomposites

Sharipova, Aliya; Unger, Ronald E.; Sosnik, Alejandro; Gutmanas, E.Y.

doi:10.1016/j.matdes.2021.109660

Cited by 8 publications

(13 citation statements)

References 44 publications

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“…Sharipova et al took a different approach to the topic because they did not use the polymer as a drug-eluting medium [ 159 ]. Instead, the iron powder was mixed with 10% Ag and VH as a model drug (used for the treatment of periprosthetic or implant-related infections).…”

Section: Iron Materials Modificationsmentioning

confidence: 99%

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

2021

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Iron, while attracting less attention than magnesium and zinc, is still one of the best candidates for biodegradable metal stents thanks its biocompatibility, great elastic moduli and high strength. Due to the low corrosion rate, and thus slow biodegradation, iron stents have still not been put into use. While these problems have still not been fully resolved, many studies have been published that propose different approaches to the issues. This brief overview report summarises the latest developments in the field of biodegradable iron-based stents and presents some techniques that can accelerate their biocorrosion rate. Basic data related to iron metabolism and its biocompatibility, the mechanism of the corrosion process, as well as a critical look at the rate of degradation of iron-based systems obtained by several different methods are included. All this illustrates as the title says, what was done within the topic of biodegradable iron-based materials and what more can be done.

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Section: Iron Materials Modificationsmentioning

confidence: 99%

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

2021

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“…People have fabricated various binary iron-based systems containing silver [ 5 , 6 , 7 ], copper [ 7 , 8 , 9 ], or zinc [ 10 , 11 ], the most common alloying elements with good antibacterial properties, though often without any intention to produce self-disinfecting products.…”

Section: Introductionmentioning

confidence: 99%

Microstructural, Mechanical and Corrosion Characteristics of Degradable PM Biomaterials Made from Copper-Coated Iron Powders

et al. 2022

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Copper-containing iron-based materials have recently been recognized as potential biomaterials possessing antimicrobial ability. Since then, iron-copper systems have been prepared by different methods and investigated. This article is focused on PM materials made from composite powders. The powders, each particle of which consisted of an iron core and a copper shell, were prepared by electroplating. Test-pieces with copper contents of 0, 3.2, and 8 wt.% were fabricated by pressing and sintering from iron and composite powders. Some microstructural, mechanical, and corrosion characteristics of test-pieces were examined. Microstructures were composed of pores and iron grains with alloyed peripheral regions and copper-free cores. As the copper content in test-pieces was increased, their density and Young’s modulus decreased, and macrohardness, corrosion potential and corrosion current density increased. Likely causes of density and Young’s modulus reduction were higher porosity, low enough copper content, and compliant inclusions in stiff matrix. The increase in macrohardness was attributed to the precipitation hardening which prevailed over softening induced by pores. The increase in corrosion potential and corrosion current density was most likely due to the presence of more noble phase providing surfaces for a faster cathodic reaction.

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“…The difference between VH-loaded Fe10Ag and Fe-Fe 2 O 3 composites is in the microstructure of Fe powders, which stems from different preparation routes of Fe10Ag and Fe-Fe 2 O 3 powders prior to the drug-loading. In the case of Fe10Ag, microstructured carbonyl Fe and Ag 2 O nanopowders undergo high-energy attrition milling, which refines them to nanostructured particles [24]. In the case of Fe-Fe 2 O 3 , microstructured carbonyl Fe was manually blended with Fe 2 O 3 nanopowders.…”

Section: (Black Plots)mentioning

confidence: 99%

“…Conversely, the fabrication of drug-loaded bulk metals is challenging because of the high temperatures used in metal processing that leads to thermal drug decomposition. Recently, we reported on the production of biodegradable vancomycin (VH)-eluting iron-silver (Fe10Ag) bulk metals by a simple high-pressure consolidation/cold sintering (CS) process at room temperature (RT) that display good mechanical strength and antibacterial activity [24]. These biodegradable drug-eluting metals showed mechanical strength comparable to that of cortical bone and extended drug delivery during five days [24].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we reported on the production of biodegradable vancomycin (VH)-eluting iron-silver (Fe10Ag) bulk metals by a simple high-pressure consolidation/cold sintering (CS) process at room temperature (RT) that display good mechanical strength and antibacterial activity [24]. These biodegradable drug-eluting metals showed mechanical strength comparable to that of cortical bone and extended drug delivery during five days [24]. At the same time, their yield strength under compression (180 MPa) and bending (118 MPa) was 4- and 8-fold lower, respectively, than drug-free Fe10Ag counterparts [25].…”

Section: Introductionmentioning

confidence: 99%

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Drug-eluting biodegradable metals and metal-ceramic composites: High strength and delayed drug release

Sharipova

Бакина

Ложкомоев

et al. 2022

Preprint

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Biodegradable metals emerged as promising temporary bone implants. The integration of additional features such as local drug delivery (LDD) can also support their osteointegration, promote bone regeneration, and prevent biomaterial-centered infections that are difficult to treat. LDD is achieved by drug-eluting coatings or porous implants where the drug is impregnated after implant fabrication because the high temperatures used during conventional production processes would result in their thermal decomposition. We produced biodegradable iron (Fe)-based vancomycin (VH)-eluting metals and metal-ceramic composites by a simple high-pressure consolidation/cold sintering (CS) process at room temperature that display high mechanical strength and antibacterial activity. Aiming to expand the application of this production method and shed light into the drug loading and release mechanisms in this type of biomaterials, this work reports on the production and characterization of VH-loaded Fe and Fe-iron oxide (Fe2O3) composites (Fe-Fe2O3). We use focus ion beam milling for the first time to investigate the drug-metal interface and investigate the mechanical and degradation properties of VH-free and VH-loaded Fe and Fe-Fe2O3. Results show very high mechanical strength of drug-eluting Fe and Fe-Fe2O3 composites (up to than 780 MPa under compression, exceeding the maximum strength of cancellous bone more than three times) accompanied by a delayed drug release. Then, we confirm the good antimicrobial activity against Staphylococcus aureus and cell compatibility with the murine embryonic fibroblast cell line NIH/3T3 in vitro. Overall results confirm the promise of drug-eluting metals and metal-ceramic composites for LDD in bone.

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Dense drug-eluting biodegradable Fe-Ag nanocomposites

Cited by 8 publications

References 44 publications

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Biodegradable Iron-Based Materials—What Was Done and What More Can Be Done?

Microstructural, Mechanical and Corrosion Characteristics of Degradable PM Biomaterials Made from Copper-Coated Iron Powders

Drug-eluting biodegradable metals and metal-ceramic composites: High strength and delayed drug release

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