Dense and Fibrous Membranes of Poly(lactic-co-glycolic acid)/Epoxidized Poly(isoprene): Chemical and Biological Evaluation

Guerra, Nayrim Brizuela; Cassel, Júlia Bünecker; Muniz, Nathália Oderich; Henckes, Nicole Andréa Corbellini; Oliveira, Fernanda dos Santos de; Cirne-Lima, Elizabeth Obino; Santos, Luís Alberto Loureiro dos

doi:10.1007/s12221-021-0971-4

Cited by 3 publications

(4 citation statements)

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“…Carrasai et al, (2021) 34 investigated the influence of the PLGA/PIepox and the connectivity on cell migration using ADSC. Additionally, Guerra et al, (2020) 28 performed another study presenting a different method of prepare PLGA/PIepox that can influence the cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…PLGA/PIepox was prepared as described previously. 26,27,28,34 The blends were obtained through the electrospinning technique, in which polyisoprene is epoxidized with PLGA (PLGA/PIepox) and dissolved in chloroform in a ratio of 3:2 (w/w). After standardizing the parameters, the metallic collector was used in a static way and the diameter of the metallic needle (0.7 mm) was maintained in all tests.…”

Section: Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…26,27 The scaffold structure in in vitro model was able to mediate cell adhesion on its surface and maintain the conditions, morphological and biochemical, exclusive to mesenchymal stem cells. 26,27,28 After this process, we identified a potential new opportunity to explore and validate in in vivo model the response in tissue host of the PLGA/PIepox combined with MSC, as proposed in the present study.…”

Section: Introductionmentioning

confidence: 99%

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Tissue engineering application combining epoxidized natural rubber blend and mesenchymal stem cells inin vivoresponse

et al. 2022

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This study aimed to investigate biocompatibility, integration, and tissue host response of the Poly (Lactic-co-Glycolic acid) (PLGA)/Poly (isoprene) (PI) epoxidized (PLGA/PIepox) innovative scaffold combined with adipose derived mesenchymal stem cells (ADSC). We implanted the scaffold subcutaneously on the back of 18 female rats and monitored them for up to 14 days. When compared to controls, PLGA/PIepox + ADSC demonstrated an earlier vascularization, a tendency of inflammation reduction, an adequate tissue integration, higher cell proliferation, and a tendency of expression of collagen decreasing. However, 14 days post-implantation we found similar levels of CD31, Ki67 and AE1/AE3 in PLGA/PIepox when compared to control groups. The interesting results, lead us to the assumption that PLGA/PIepox is able to provide an effective delivery system for ADSC on tissue host. This animal study assesses PLGA/PIepox + ADSC in in vivo tissue functionality and validation of use, serving as a proof of concept for future clinical translation as it presents an innovative and promising tissue engineering opportunity for the use in tissue reconstruction.

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Section: Discussionmentioning

confidence: 99%