Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation

Zhou, Hao; Fan, Zhiyuan; Li, Peter Y.; Deng, Junjie; Arhontoulis, Dimitrios C.; Li, Christopher Y.; Bowne, Wilbur B.; Cheng, Hao

doi:10.1021/acsnano.8b04947

Cited by 164 publications

(145 citation statements)

References 68 publications

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“…The use of longer and more densely packed dextran did not cause any relevant amount of complement activation through any pathway. These results somewhat consolidate what was previously established for PEG (Zhou et al, 2018).…”

Section: Synthetic Approachessupporting

confidence: 91%

Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of “Stealthy” Nanomaterials

Rampado

Crotti

Caliceti

et al. 2020

Front. Bioeng. Biotechnol.

245

166

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In the last decades, the staggering progress in nanotechnology brought around a wide and heterogeneous range of nanoparticle-based platforms for the diagnosis and treatment of many diseases. Most of these systems are designed to be administered intravenously. This administration route allows the nanoparticles (NPs) to widely distribute in the body and reach deep organs without invasive techniques. When these nanovectors encounter the biological environment of systemic circulation, a dynamic interplay occurs between the circulating proteins and the NPs, themselves. The set of proteins that bind to the NP surface is referred to as the protein corona (PC). PC has a critical role in making the particles easily recognized by the innate immune system, causing their quick clearance by phagocytic cells located in organs such as the lungs, liver, and spleen. For the same reason, PC defines the immunogenicity of NPs by priming the immune response to them and, ultimately, their immunological toxicity. Furthermore, the protein corona can cause the physical destabilization and agglomeration of particles. These problems induced to consider the PC only as a biological barrier to overcome in order to achieve efficient NP-based targeting. This review will discuss the latest advances in the characterization of PC, development of stealthy NP formulations, as well as the manipulation and employment of PC as an alternative resource for prolonging NP half-life, as well as its use in diagnostic applications.

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Section: Synthetic Approachessupporting

confidence: 91%

Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of “Stealthy” Nanomaterials

Rampado

Crotti

Caliceti

et al. 2020

Front. Bioeng. Biotechnol.

245

166

View full text Add to dashboard Cite

show abstract

“…Click reaction between azide and alkyne was then performed to decorate the micelle with anti‐PD‐1 antibodies via matrix metalloproteinase‐2 (MMP‐2) sensitive peptide linker and sheddable long‐chain PEG (PEG 20k ) via acid‐labile bond. Owing the long circulation of stealth nanoparticles with PEG corona, the micelle named sAMcP may co‐deliver aPD‐1 and PTX into tumor site via passive tumor accumulation. Then, PEG 20k shedding and aPD‐1 release may be triggered by the weak acidity (pH ≈ 6.5) and enriched MMP‐2 (10–50 × 10 −9 m ) of tumor microenvironment, respectively, which may also turn the negatively charged micelle to a positively charged one (McP) for an easy internalization into cancer cells because of the detachment of negatively charged antibody and partial protonation of Dip groups.…”

Section: Introductionmentioning

confidence: 99%

Codelivery of Anti‐PD‐1 Antibody and Paclitaxel with Matrix Metalloproteinase and pH Dual‐Sensitive Micelles for Enhanced Tumor Chemoimmunotherapy

Xiao

Wang

et al. 2020

Small

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Immune checkpoint blockade (ICB) is demonstrating great potential in cancer immunotherapy nowadays. Yet, the low response rate to ICB remains an urgent challenge for tumor immunotherapy. A pH and matrix metalloproteinase dual‐sensitive micellar nanocarrier showing spatio‐temporally controlled release of anti‐PD‐1 antibody (aPD‐1) and paclitaxel (PTX) in solid tumors is prepared to realize synergistic cancer chemoimmunotherapy. Antitumor immunity can be activated by PTX‐induced immunogenic cell death (ICD), while aPD‐1 blocks the PD‐1/PD‐L1 axis to suppress the immune escape due to PTX‐induced PD‐L1 up‐regulation, thus resulting in a synergistic antitumor chemoimmunotherapy. Through decoration with a sheddable polyethylene glycol (PEG) shell, the nanodrug may better accumulate in tumors to boost the synergistic antitumor treatment in a mouse melanoma model. The present study demonstrates a potent antitumor chemoimmunotherapy utilizing tumor microenvironment‐sensitive micelles bearing a sheddable PEG layer to mediate site‐specific sequential release of aPD‐1 and PTX.

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“…Measurements of the interaction of these nanoparticles with fetal bovine serum showed that all the PEGylated particles generated adsorbed a similar quantity of proteins, which was smaller than the amount of protein found in the non-PEGylated particles (as previously shown). However, particles with a double layer of PEG bound to proteins with different binding affinities [49]. .…”

Section: Pegylated Coatingsmentioning

confidence: 99%

Recent Developments in the Design of Non-Biofouling Coatings for Nanoparticles and Surfaces

Sanchez‐Cano

Carril

2020

IJMS

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Biofouling is a major issue in the field of nanomedicine and consists of the spontaneous and unwanted adsorption of biomolecules on engineered surfaces. In a biological context and referring to nanoparticles (NPs) acting as nanomedicines, the adsorption of biomolecules found in blood (mostly proteins) is known as protein corona. On the one hand, the protein corona, as it covers the NPs’ surface, can be considered the biological identity of engineered NPs, because the corona is what cells will “see” instead of the underlying NPs. As such, the protein corona will influence the fate, integrity, and performance of NPs in vivo. On the other hand, the physicochemical properties of the engineered NPs, such as their size, shape, charge, or hydrophobicity, will influence the identity of the proteins attracted to their surface. In this context, the design of coatings for NPs and surfaces that avoid biofouling is an active field of research. The gold standard in the field is the use of polyethylene glycol (PEG) molecules, although zwitterions have also proved to be efficient in preventing protein adhesion and fluorinated molecules are emerging as coatings with interesting properties. Hence, in this review, we will focus on recent examples of anti-biofouling coatings in three main areas, that is, PEGylated, zwitterionic, and fluorinated coatings.

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Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation

Cited by 164 publications

References 68 publications

Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of “Stealthy” Nanomaterials

Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of “Stealthy” Nanomaterials

Codelivery of Anti‐PD‐1 Antibody and Paclitaxel with Matrix Metalloproteinase and pH Dual‐Sensitive Micelles for Enhanced Tumor Chemoimmunotherapy

Recent Developments in the Design of Non-Biofouling Coatings for Nanoparticles and Surfaces

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