Dengue viruses: their evolution, history and emergence as a global public health problem.

Gubler, Duane J.; Ooi, Eng Eong; Vasudevan, Subhash G.; Farrar, Jeremy

doi:10.1079/9781845939649.0001

Cited by 94 publications

(101 citation statements)

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“…The 3’NTR, in which different substitutions were observed defining the 1992/94 viruses and group III viruses, interacts with viral and/or cellular proteins in viral RNA synthesis, replication and genome cyclization (Alvarez et al 2006; Friebe et al 2011). Other studies implicate different genetic alterations in dengue viruses associated with changes in epidemic intensity: Steel et al (2010) report changes in prM, NS2A and NS4A genes associated with attenuation, as measured by number of cases and virus isolation rates, of DENV-2 viruses from the 1970s causing a series of outbreaks in the south Pacific (Gubler and Kuno, 1997; Gubler, 2014); changes in the envelope gene and the untranslated regions of DENV-2 have been associated with increased epidemic intensity within human populations (Leitmeyer et al 1999; Bennett et al 2006). A change in the circulating strains of DENV-3 have been associated with the onset of clinical severity in Sri Lanka (Lanciotti et al 1994; Messer et al 2003), and attenuation in Indonesia (Gubler et al 1981).…”

Section: Discussionmentioning

confidence: 99%

“…DENV is a fast-evolving single-stranded, positive sense RNA virus of the genus Flavivirus in the family Flaviviridae . Evidence suggests that the four distinct serotypes of DENV (DENV-1 to DENV-4) originally diverged in canopy-dwelling mosquitoes and nonhuman primates in the rainforests of Asia, before colonizing humans several hundred years ago, each serotype undergoing a burst of evolutionary change associated with adaptations to new vectors and/or humans, and their demographic expansions (Wang et al 2000; Twiddy et al 2002a; Twiddy, et al 2002b; Vasilakis et al 2008; Gubler, 2014). …”

Section: Introductionmentioning

confidence: 99%

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Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence

Martin

Chirivella

et al. 2016

Virus Research

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Dengue has emerged globally as a major human health problem since the 1950s and is now the most important arboviral disease of humans, infecting nearly 400 million people annually. While some cases are asymptomatic, others can develop a febrile illness (dengue fever) or even progress to severe and fatal dengue. Dengue is caused by any of four closely related but distinct viruses, known as Dengue virus serotype 1 to 4 (DENV-1 to DENV-4) which are maintained in endemic transmission to humans in large urban centers of the tropics by Aedes mosquitoes. Since the early 1960s, Puerto Rico, a major metropolitan center in the Caribbean, has experienced increasingly larger and clinically more severe epidemics following the introduction of all four dengue serotypes. The first dengue hemorrhagic fever epidemic in 1986, and a particularly severe outbreak in 1998 were dominated by novel DENV-4 strains that evolved in Puerto Rico, replacing earlier strains and spreading throughout the region. Sequence characterization of 54 complete DENV-4 genomes and their comparative evolution against 74 previously published viral sequences from the region over several decades shows that DENV-4 strains from these periods were genetically distinct based on unique changes in the envelope and non-structural genes. Their replacement of earlier strains in Puerto Rico progressed rapidly, suggesting that strong natural selection played a role in their fixation. This study confirms that DENVs evolve through rapid lineage turnover driven in part by natural selection and genetic drift.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence

Martin

Chirivella

et al. 2016

Virus Research

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“…Clinical manifestations of dengue range from asymptomatic or mild acute febrile illness (AFI) to circulatory failure and death from dengue hemorrhagic fever (DHF). Urbanization, rapid movement of humans facilitated by modern transportation and other socioeconomic factors, and geographic expansion of dengue’s primary vector, Aedes aegypti , have fueled the current global dengue pandemic [2]. …”

Section: Introductionmentioning

confidence: 99%

Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua

et al. 2016

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BackgroundDengue is an emerging infectious disease of global significance. Suspected dengue, especially in children in Nicaragua’s heavily-urbanized capital of Managua, has been well documented, but unsuspected dengue among children and adults with undifferentitated fever has not.Methodology/Principal FindingsTo prospectively study dengue in semi-urban and rural western Nicaragua, we obtained epidemiologic and clinical data as well as acute and convalescent sera (2 to 4 weeks after onset of illness) from a convenience sample (enrollment Monday to Saturday daytime to early evening) of consecutively enrolled patients (n = 740) aged ≥ 1 years presenting with acute febrile illness. We tested paired sera for dengue IgG and IgM and serotyped dengue virus using reverse transcriptase-PCR. Among 740 febrile patients enrolled, 90% had paired sera. We found 470 (63.5%) were seropositive for dengue at enrollment. The dengue seroprevalance increased with age and reached >90% in people over the age of 20 years. We identified acute dengue (serotypes 1 and 2) in 38 (5.1%) patients. Only 8.1% (3/37) of confirmed cases were suspected clinically.Conclusions/SignificanceDengue is an important and largely unrecognized cause of fever in rural western Nicaragua. Since Zika virus is transmitted by the same vector and has been associated with severe congenital infections, the population we studied is at particular risk for being devastated by the Zika epidemic that has now reached Central America.

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“…De hecho, en los diferentes países en que ha aparecido esta enfermedad se le ha aplicado distintos nombres. Por ejemplo, los ingleses la llamaron "dandyfever" y "pantomimefever"; los norteamericanos "breakbone fever" (fiebre rompe huesos) y "broken-wing" (ala rota); los brasileros "fiebre-polka" y los españoles "la piadosa", "pantomima", "calentura roja", "fiebre de aclimatación", "fiebre datilera" o "fiebre de Don Simón" (Gubler, 2014).…”

Section: Arbovirosis De Mayor Repercusión En La Salud Pública De La Runclassified

“…Empero, la primera epidemia americana de dengue confirmada serológicamente (DEN-3) no tendría lugar hasta 1963, afectando, entre otras zonas, a Jamaica, Puerto Rico, las islas de las Antillas Menores y Venezuela, aunque no llegó a Cuba, La Española ni Trinidad. Anteriormente sólo se había aislado el DEN-2 en Trinidad en 1951, en una situación no epidémica (Gubler, 2014).…”

Section: Arbovirosis De Mayor Repercusión En La Salud Pública De La Runclassified

Arbovirosis Transmitidas Por Mosquitos (Diptera: Culicidae) en La República Dominicana: Una Revisión

Alarcón-Elbal¹,

Paulino-Ramírez²,

Diéguez-Fernández³

et al. 2017

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Among the emerging infectious diseases, the arboviral diseases group has a significant impact worldwide due to its epidemic potential and unprecedented spread. These diseases, mostly zoonoses, represent a serious public health problem in the Americas and especially in the Caribbean, which have a nearly uninterrupted transmission pattern throughout the year and are becoming an obstacle to economic development. In fact, in recent decades there has been a significant increase in the number of epidemiological outbreaks caused by emerging and reemerging arbovirus in many Caribbean countries, as in the case of Dominican Republic, where the incidence of diseases such as dengue, chikungunya and most recently Zika and Mayaro viruses have grown considerably causing great concern in public health. Clearly, other factors such as the lack of sources and proper action plans, among other reasons, have a negative influence in the control of these viruses. The current work aims to provide a picture of the main arboviral diseases spread by mosquitoes (Diptera: Culicidae) that affect the Caribbean islands, particularly the island of Hispaniola, the second largest of the Antilles.

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Dengue viruses: their evolution, history and emergence as a global public health problem.

Cited by 94 publications

References 0 publications

Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence

Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence

Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua

Arbovirosis Transmitidas Por Mosquitos (Diptera: Culicidae) en La República Dominicana: Una Revisión

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