Dengue viruses in Papua New Guinea: evidence of endemicity and phylogenetic variation, including the evolution of new genetic lineages

Moore, Peter W.; Hurk, Andrew F. van den; Mackenzie, John S.; Pyke, Alyssa T.

doi:10.1038/emi.2017.103

Cited by 29 publications

(36 citation statements)

References 46 publications

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“…DENV‐3 was reported as the dominant serotype in regions including Bali (2015), Central Java (2015), Yogyakarta (2015), East Borneo (2015), and in returning Taiwanese travellers in 2014. Data from Australian travellers returning from Indonesia also suggested that DENV‐2 and ‐3 were the predominant serotypes during 2013 to 2015 . There were similar findings in a study of international travellers visiting Bali (2015 to 2017) .…”

Section: Resultssupporting

confidence: 66%

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

Harapan

Michie

Yohan

et al. 2019

Reviews in Medical Virology

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Although epidemiological and molecular epidemiological (serotype, genotype, and lineage information) data are available for several major cities in Indonesia, there is yet to be a comprehensive national study of dengue in Indonesia over time. This study was conducted to provide a comprehensive epidemiology of circulating dengue viruses (DENV) in Indonesia between 1973 and 2016. This was conducted through a systematic review of the literature and phylogenetic analysis of available DENV sequences. Available data from National Disease Surveillance System have indicated an increasing trend of dengue incidence in Indonesia over the past 50 years. Incidence rates appear to be cyclic, peaking approximately every 6 to 8 years. In contrast, the case fatality rate has decreased approximately by half with each decade since 1980.Over this 50-year time span, serotype shifts, genotype displacement within DENV-1 and DENV-2, and introduction of DENV-1 and DENV-3 genotype from other countries occurred. These events were associated with increased incidence of dengue cases. Our study also provides a valuable national snapshot of DENV genetic diversity in Indonesia that may contribute to development of more effective dengue vaccine compositions for the region.

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Section: Resultssupporting

confidence: 66%

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

Harapan

Michie

Yohan

et al. 2019

Reviews in Medical Virology

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“…A neighbor-joining phylogenetic tree ( Figure 4) made with a mix of other DENV-2 genotype references placed the new sequences within the cosmopolitan genotype (17,19). However, this strain differed from other DENV-2 cosmopolitan strains reported previously in Sri Lanka (18,20) and was more closely related to variants isolated from Singapore and China during 2014-2017.…”

Section: Phylogenetic Analysiscontrasting

confidence: 63%

Severe Dengue Epidemic, Sri Lanka, 2017

Tissera¹,

Jayamanne²,

Raut³

et al. 2020

Emerg. Infect. Dis.

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G lobal incidence of dengue has increased 7-fold, from 8.3 million cases in 1990 to >58.4 million in 2013 (1). Currently, ≈390 million new infections occur annually in 128 dengue-endemic countries (2). Worldwide, ≈14,000-20,000 dengue-related deaths occur each year (1,2). In dengue-endemic countries, Aedes (Stegomyia) aegypti and Ae. (Stegomyia) albopictus mosquito vectors transmit the disease. Sri Lanka, a tropical island in the Indian Ocean (population 21 million) (3), has reported dengue cases since the 1960s; seasonal epidemics predominantly affect areas that have annual rainfall >2,500 mm (4). However, until 1988, the more severe form of dengue virus (DENV) infection, dengue hemorrhagic fever, was reported only sporadically (5,6). During 1991-2008, dengue epidemics occurred once every few years on the background of endemic transmission (6). A disproportionate epidemic occurred in 2009 comprising 35,008 suspected cases (incidence 170 cases/100,000 population) and 346 deaths (case-fatality rate 1%) (7). During 2010-2016, dengue became a major public health problem; cases increased steadily (from 28,473 in 2011 to 55,150 in 2016) throughout the country but disproportionately affected the most populated Western province (7). In 2017, a total of 186,101 suspected cases and 440 dengue-related deaths were reported to the Central Epidemiology Unit of the Ministry of Health, Sri Lanka (7). This number is the highest number of suspected cases reported in a single calendar year in Sri Lanka since dengue was designated a notifiable disease in 1996. We compared the temporal, epidemiologic, virologic, entomologic, and climatic characteristics of the 2017 dengue epidemic with those of the epidemics during the preceding 5 years (2012-2016). Methods Data Sources Epidemiology We obtained epidemiologic data from the integrated national communicable disease surveillance system, which captures symptomatic dengue patients classified according to a standard case definition based on the 1997-2011 World Health Organization classification (8). Etiologic screening was conducted with NS1 antigen testing or dengue antibody assays. However, given the limited diagnostic test availability, especially in remote areas of the country, many cases were clinically diagnosed using the surveillance case

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“…Likely origins of outbreaks were determined following sequence alignment and phylogenetic tree analysis as previously described 8,9 .…”

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confidence: 99%

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confidence: 99%

“…Queensland is vulnerable to outbreaks of dengue viruses (DENVs) and indeed, due to endemic populations of the mosquito vector Aedes aeypti, Likely origins of outbreaks were determined following sequence alignment and phylogenetic tree analysis as previously described 8,9 .Outbreak strains were considered to have been sourced from a particular region after demonstrating very high percentage sequence identities (99%) and evolutionary relatedness with the strain identified and sequenced from the index case (where available) or clusters of strains (two or more) which were themselves …”

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confidence: 99%

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The origins of dengue outbreaks in northern Queensland, Australia, 1990–2017

Pyke¹

2018

Microbiol. Aust.

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Dengue is one of the world's major infectious mosquitoborne diseases and although not endemic in Australia, is a significant public health concern. Queensland is vulnerable to outbreaks of dengue viruses (DENVs) and indeed, due to endemic populations of the mosquito vector Aedes aeypti, Likely origins of outbreaks were determined following sequence alignment and phylogenetic tree analysis as previously described 8,9 .Outbreak strains were considered to have been sourced from a particular region after demonstrating very high percentage sequence identities (99%) and evolutionary relatedness with the strain identified and sequenced from the index case (where available) or clusters of strains (two or more) which were themselves

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Dengue viruses in Papua New Guinea: evidence of endemicity and phylogenetic variation, including the evolution of new genetic lineages

Cited by 29 publications

References 46 publications

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

Severe Dengue Epidemic, Sri Lanka, 2017

The origins of dengue outbreaks in northern Queensland, Australia, 1990–2017

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