Dengue virus transmission from live donor liver graft

Mathew, Johns Shaji; Menon, Vidya; Menon, Veena; Mallick, Shweta; Amma, Binoj Sivasankara Pillai Thankamony; Balakrishnan, Dinesh; Gopalakrishnan, Unnikrishnan; Ramachandran, Riju; Athira, Padmanabhan P; Jagan, Ozhiparambil A; Sudhindran, S.

doi:10.1111/ajt.15270

Cited by 20 publications

(8 citation statements)

References 29 publications

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“…In addition, the 3–14-day incubation period of DENV and the poorly understood respiratory transmission mechanism makes the epidemiological investigation more difficult [ 36 ]. Importantly, people may have ignored the potential of alternate transmission routes for DENV, such as intranasal, aerosol, and sexual transmission routes, which may explain why the majority of atypical transmission cases occur in hospitals, laboratories, and non-endemic areas where mosquito control strategies are well implemented [ 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Effective Infection with Dengue Virus in Experimental Neonate and Adult Mice through the Intranasal Route

Qiu

Zhao

Zhang

et al. 2022

Viruses

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Dengue virus, the causative agent of dengue fever, life-threatening hemorrhagic fever, and shock syndrome, is mainly transmitted to humans through mosquito vectors. It can also be transmitted through atypical routes, including needle stick injury, vertical transmission, blood transfusion, and organ transplantation. In addition, sporadic cases which have no clear infectious causes have raised the respiratory exposure concerns, and the risks remain unclear. Here, we analyze the respiratory infectivity of the dengue virus in BALB/c suckling and adult immunodeficient mice by the intranasal inoculation of dengue virus serotype 2. The infected mice presented with clinical symptoms, including excitement, emaciation, malaise, and death. Viremia was detected for 3 days post inoculation. Histopathological changes were observed in the brain, liver, and spleen. The virus showed evident brain tropism post inoculation and viral loads peaked at 7 days post inoculation. Furthermore, the virus was isolated from the infected mice; the sequence homology between the origin and isolates was 99.99%. Similar results were observed in adult IFN-α/β receptor-deficient mice. Overall, dengue virus can infect suckling mice and adult immune-deficient mice via the nasal route. This study broadens our perception of atypical dengue transmission routes and provides evidence of nasal transmission of dengue virus in the absence of mosquito vectors.

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Section: Discussionmentioning

confidence: 99%

Effective Infection with Dengue Virus in Experimental Neonate and Adult Mice through the Intranasal Route

Qiu

Zhao

Zhang

et al. 2022

Viruses

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“…Many studies have described emerging and re-emerging viral pathogens like dengue, rabies, HTLV, Zika and others in the transplant recipients with their severity and complications in post-transplant period [ 4 ]. Although many authors reported dengue transmission through graft in solid organ transplants like liver, kidney & heart [ 5 ]. Until now only two case reports have discussed the transmission of dengue virus through HSCT graft [ 2 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

Dengue virus transmission from donor to recipient during haploidentical stem cell transplantation

Yadav

Rastogi

Upasana

et al. 2021

IDCases

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Dengue fever is endemic in tropical and subtropical countries. Dengue virus transmission through hematopoietic stem cells is very rare and just two such cases have been reported previously. We report here only third case of dengue virus transmission in a 2-year-old child with thalassemia major who underwent hematopoietic stem cell transplant (HSCT) from a haploidentical related donor. One week after HSCT, the recipient developed fever, pancytopenia and signs of capillary leak. On day 10, his dengue NS1 antigen test was positive which confirmed diagnosis of dengue fever. Donor also had fever few days prior to stem cell donation which was later diagnosed to be due to dengue fever. Child had a severe clinical course of dengue leading to primary graft failure. However, he had autologous recovery of his own bone marrow and is alive and well on day+200 post HSCT. Our report highlights the transmission of dengue virus from donor to recipient through hematopoietic stem cell graft although rare but possible. We suggest that in tropical and subtropical countries where dengue is endemic, hematopoietic stem cell donors should be screened for it.

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“…Table 1 represents a review of cases in the literature of potential or confirmed dengue transmission through organ transplantation. [19][20][21][22][23][24][25][26] . Most cases are documented based on the early onset of symptoms in the recipient after transplantation and, in several instances, the occurrence of dengue fever in more than one recipient from the same donor.…”

Section: Transmission Of Dengue By the Donor And Mitigation Measuresmentioning

confidence: 99%

“…However, in most reports, it is impossible to unequivocally confirm the transmission of dengue by the donor due to the lack of confirmation of viral PCR in the donor and recipients. Genetic sequencing was carried out in just one case, with 99.9% homology found when comparing the donor and recipient viruses 23 . Furthermore, there are cases of possible transmission from donors with negative PCR-DENV in the blood performed during laboratory screening.…”

Section: Transmission Of Dengue By the Donor And Mitigation Measuresmentioning

confidence: 99%

Recommendations for Dengue Screening Protocol for Donors and Recipients in Solid Organ Transplantation

Santos,

Stucchi,

Clemente

et al. 2024

BJT

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Dengue, an infection characterized by recurrent epidemic spanning 3 to 5 years, stands out as a one of the most prominent problem due to its escalating case number and geographic extension. Despite its vast distribution, the disease occurs most intensely in the Americas and Southeast Asia. Within this scenario, it is imperative to carefully assess the potential repercussions of this epidemic on transplant activity. Although literature on this matter remains sparse, a review of probable and confirmed cases of dengue transmission through infected donors was carried out, addressing clinical characteristics and outcomes in recipients of such organs. Considering the strategies adopted in other countries that have already experienced dengue epidemics with the transmission of the virus through organ transplantation, the Comissão de Infecção em Transplante (COINT) da Associação Brasileira de Transplante (ABTO) delineates a protocol for screening potential donors and transplant candidates. This protocol involves the combined use of NS1/IgM on blood, alongise stringent criteria for evaluating donor and recipient suitability.

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Dengue virus transmission from live donor liver graft

Cited by 20 publications

References 29 publications

Effective Infection with Dengue Virus in Experimental Neonate and Adult Mice through the Intranasal Route

Effective Infection with Dengue Virus in Experimental Neonate and Adult Mice through the Intranasal Route

Dengue virus transmission from donor to recipient during haploidentical stem cell transplantation

Recommendations for Dengue Screening Protocol for Donors and Recipients in Solid Organ Transplantation

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