Abstract:TGF-β signaling is tightly regulated to ensure cellular functions. Role of DENV on the TGF-β/Smad signaling has not been well established. Therefore, we aimed to study the association between DENV infection and TGF-β/Smad signaling. We observed significant impairment in the expression of Smad2, Smad3, Smad4, Smad6 and Smad7 during DENV replication, which are the key players in TGF-β signaling. Significant reduction in the expression of phosphorylated Smad3 was also documented. Overexpression of Smad2/3/4/6 pro… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.