Dengue virus infections

Fonseca, Benedito Antônio Lopes da; Fonseca, Sílvia Nunes Szente

doi:10.1097/00008480-200202000-00012

Cited by 45 publications

(46 citation statements)

References 28 publications

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“…3 belonging to mosquito-born flaviviruses are single-stranded positive-polarity RNA viruses that cause serious infectious diseases all over the world especially in Asian and Latin American countries (1,2). Infection by DV may result in benign course called dengue fever (DF) or life-threatening presentations such as dengue hemorrhagic fever (DHF) and dengue shock syndrome.…”

Section: Engue Viruses (Dv)mentioning

confidence: 99%

Dengue Virus Type 2 Antagonizes IFN-α but Not IFN-γ Antiviral Effect via Down-Regulating Tyk2-STAT Signaling in the Human Dendritic Cell

Ho¹,

Hung²,

Weng

et al. 2005

The Journal of Immunology

136

128

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The immunopathogenesis mechanism of dengue virus (DV) infection remains elusive. We previously showed that the target of DV in humans is dendritic cells (DCs), the primary sentinels of immune system. We also observed that despite the significant amount of IFN-α induced; DV particles remain massively produced from infected DCs. It suggests that DV may antagonize the antiviral effect of IFN-α. Recent work in animal studies demonstrated the differential critical roles of antiviral cytokines, namely IFN-α/IFN-β and IFN-γ, in blocking early viral production and in preventing viral-mediated disease, respectively. In this study, we examined the effects of IFN-α and IFN-γ in DV infection of monocyte-derived DCs. We showed that the preinfection treatment with either IFN-α or IFN-γ effectively armed DCs and limited viral production in infected cells. However, after infection, DV developed mechanisms to counteract the protection from lately added IFN-α, but not IFN-γ. Such a selective antagonism on antiviral effect of IFN-α, but not IFN-γ, correlated with down-regulated tyrosine-phosphorylation and DNA-binding activities of STAT1 and STAT3 transcription factors by DV. Furthermore, subsequent studies into the underlying mechanisms revealed that DV attenuated IFN-α-induced tyrosine-phosphorylation of Tyk2, an upstream molecule of STAT activation, but had no effect on expression of both IFN-α receptor 1 and IFN-α receptor 2. Moreover, DV infection by itself could activate STAT1 and STAT3 through IFN-α-dependent and both IFN-α-dependent and IFN-α-independent mechanisms, respectively. These observations provide very useful messages with physiological significance in investigation of the pathogenesis, the defense mechanisms of human hosts and the therapeutic considerations in DV infection.

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Section: Engue Viruses (Dv)mentioning

confidence: 99%

Dengue Virus Type 2 Antagonizes IFN-α but Not IFN-γ Antiviral Effect via Down-Regulating Tyk2-STAT Signaling in the Human Dendritic Cell

Ho¹,

Hung²,

Weng

et al. 2005

The Journal of Immunology

136

128

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“…A more severe clinical presentation, dengue haemorrhagic fever/ dengue shock syndrome (DHF/DSS), is characterized by increased vascular permeability, thrombocytopenia (platelets <100,000), bleeding tendency, and, in a small percentage of patients, circulatory shock. [2][3][4][5] In addition, especially during large outbreaks, atypical clinical manifestations have been described, such as encephalitis, Guillain-Barré syndrome, and fulminant hepatitis. 6,7 Cardiac involvement in dengue has been reported in few studies, usually resulting in a benign and self-limited disease.…”

Section: Introductionmentioning

confidence: 99%

A case presentation of a fatal dengue myocarditis showing evidence for dengue virus-induced lesion

Miranda

Borges

Schmidt

et al. 2013

European Heart Journal: Acute Cardiovascular Care

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Dengue is a prevalent arthropod-borne viral disease in tropical and subtropical areas of the globe. Dengue clinical manifestations include asymptomatic infections; undifferentiated fever; dengue fever, which is characterized by fever, headache, retroorbital pain, myalgia, and arthralgia; and a severe form of the disease denominated dengue haemorrhagic fever/dengue shock syndrome, characterized by haemoconcentration, thrombocytopenia, and bleeding tendency. However, atypical manifestations, such as liver, central nervous system, and cardiac involvement, have been increasingly reported. We report an atypical and rare presentation of dengue disease marked by a dramatic and fatal cardiogenic shock due to acute myocarditis. Histopathological analysis of heart tissue showed several multifocal areas of muscle necrosis and intense interstitial oedema associated with clusters of virus particles inside the cardiomyocytes and in the interstitial space, providing evidence of a possible direct action of dengue virus on myocardium.

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“…With the rapid growth of population, urbanization, and modernization, countries that are located in the tropical and subtropical areas, both developing and developed, may have the problems of increasing prevalence of chronic kidney disease (CKD)/ESRD (9) and be at risk from dengue endemics (10,11). In the 2002 outbreak of dengue fever in southern Taiwan, most of these patients were adults and several patients who died had the concomitant underlying disease of chronic renal failure (CRF).…”

mentioning

confidence: 99%

Impact of Renal Failure on the Outcome of Dengue Viral Infection

Kuo¹,

Lu²,

Chang³

et al. 2008

Clinical Journal of the American Society of Nephrology

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Background and objectives: In the 2002 dengue outbreak in Taiwan, some fatal cases had the underlying disease of renal failure (RF). Physicians faced difficulty in diagnosis and treatment of these patients; however, the impacts of RF on the clinical presentations and outcomes of dengue infection have not been reported previously.Design, setting, participants, & measurements: A retrospective review was conducted of medical records, clinical presentations, laboratory findings, and underlying diseases for all cases of dengue infection in a medical center. Characteristics and outcomes of dengue-infected patients with and without RF were compared.Results: From January 2002 through January 2003, 519 dengue-infected patients were enrolled, including 412 patients with classical dengue fever (DF) and 107 patients with dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Twelve patients died in this outbreak, and all had DHF/DSS. Twenty-one (4.0%) patients were defined as being in the RF group. The RF group had a higher mortality rate than non-RF group (28.6 versus 1.2%; P < 0.001). The severity of GFR impairment was associated with higher percentages of DHF/DSS (P ‫؍‬ 0.029) and mortality (P < 0.001). Differences in symptoms/signs and laboratory abnormalities between DF and DHF/DSS were significant in the non-RF group but not apparent in the RF group.Conclusions: The diagnosis and management of dengue infection among patients with RF must be cautious, because complicated clinical courses with a higher mortality rate were well observed.

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Dengue virus infections

Cited by 45 publications

References 28 publications

Dengue Virus Type 2 Antagonizes IFN-α but Not IFN-γ Antiviral Effect via Down-Regulating Tyk2-STAT Signaling in the Human Dendritic Cell

Dengue Virus Type 2 Antagonizes IFN-α but Not IFN-γ Antiviral Effect via Down-Regulating Tyk2-STAT Signaling in the Human Dendritic Cell

A case presentation of a fatal dengue myocarditis showing evidence for dengue virus-induced lesion

Impact of Renal Failure on the Outcome of Dengue Viral Infection

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