Dengue virus infection changes Aedes aegypti oviposition olfactory preferences

Gaburro, Julie; Paradkar, Prasad N.; Klein, Melissa J.; Bhatti, Asim; Nahavandi, Saeid; Duchemin, Jean‐Bernard

doi:10.1038/s41598-018-31608-x

Cited by 25 publications

(18 citation statements)

References 56 publications

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“…Contrary to what has been described previously [33,78], only three members of the chemosensory gene families were differentially regulated in response to a change in infection status. While previous studies have demonstrated a connection between behavioral sensitivity and an increased transcript abundance of select ORs and OBPs [33,34], this study identified IR75k.1 as the only chemosensory gene to change (decrease) in response to DENV-1 infection. The orthologue, AgamIR75k, in Anopheles gambiae has been shown to respond to short chain carboxylic acids [79,80], which regulate host seeking in mosquitoes [81,82].…”

Section: Discussioncontrasting

confidence: 67%

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Dengue infection modulates locomotion and host seeking in Aedes aegypti

Tallon

Lorenzo

Moreira³

et al. 2020

PLoS Negl Trop Dis

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Pathogens may manipulate their human and mosquito hosts to enhance disease transmission. Dengue, caused by four viral serotypes, is the fastest-growing transmissible disease globally resulting in 50-100 million infections annually. Transmission of the disease relies on the interaction between humans and the vector Aedes aegypti and is largely dependent on the odor-mediated host seeking of female mosquitoes. In this study, we use activity monitors to demonstrate that dengue virus-1 affects the locomotion and odor-mediated behavior of Ae. aegypti, reflecting the progression of infection within the mosquito. Mosquitoes 4-6 days post-infection increase locomotion, but do not alter their odor-driven host-seeking response. In contrast, females 14-16 days post-infection are less active, yet more sensitive to human odors as assessed by behavioral and electrophysiological assays. Such an increase in physiological and behavioral sensitivity is reflected by the antennal-specific increase in abundance of neural signaling transcripts in 14 days post-infection females, as determined by transcriptome analysis. This suggests that the sensitivity of the mosquito peripheral olfactory system is altered by the dengue virus by enhancing the overall neural responsiveness of the antenna, rather than the selective regulation of chemosensoryrelated genes. Our study reveals that dengue virus-1 enhances vector-related behaviors in the early stages post-infection that aid in avoiding predation and increasing spatial exploration. On the other hand, at the later stages of infection, the virus enhances the host-seeking capacity of the vector, thereby increasing the risk of virus transmission. A potential mechanism is discussed.

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Section: Discussioncontrasting

confidence: 67%

“…While DENV-2 infection has been shown to affect the odor-mediated oviposition behavior of gravid Ae . aegypti [ 34 ], such an effect has not yet been described for the characteristic odor-mediated behavior of host seeking females.…”

Section: Introductionmentioning

confidence: 99%

Dengue infection modulates locomotion and host seeking in Aedes aegypti

Tallon

Lorenzo

Moreira³

et al. 2020

PLoS Negl Trop Dis

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“…Arbovirus infection may also be associated with changes in the expression of other categories of biological processes, such as arbovirus infection changes in Ae. aegypti blood feeding behavior and oviposition olfactory preferences [46,47,48].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Analysis of Aedes aegypti Innate Immune System in Response to Ingestion of Chikungunya Virus

Zhao

Alto

Jiang

et al. 2019

IJMS

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Aedes aegypti (L.) is the primary vector of emergent mosquito-borne viruses, including chikungunya, dengue, yellow fever, and Zika viruses. To understand how these viruses interact with their mosquito vectors, an analysis of the innate immune system response was conducted. The innate immune system is a conserved evolutionary defense strategy and is the dominant immune system response found in invertebrates and vertebrates, as well as plants. RNA-sequencing analysis was performed to compare target transcriptomes of two Florida Ae. aegypti strains in response to chikungunya virus infection. We analyzed a strain collected from a field population in Key West, Florida, and a laboratory strain originating from Orlando. A total of 1835 transcripts were significantly expressed at different levels between the two Florida strains of Ae. aegypti. Gene Ontology analysis placed these genes into 12 categories of biological processes, including 856 transcripts (up/down regulated) with more than 1.8-fold (p-adj (p-adjust value) ≤ 0.01). Transcriptomic analysis and q-PCR data indicated that the members of the AaeCECH genes are important for chikungunya infection response in Ae. aegypti. These immune-related enzymes that the chikungunya virus infection induces may inform molecular-based strategies for interruption of arbovirus transmission by mosquitoes.

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“…gambiae infected with the malaria parasite Plasmodium falciparum displayed an increased attraction to floral nectar sources and sugar uptake. Moreover, Gaburro et al ( 2018a , b ) showed that the oviposition preference of Ae. aegypti , based on larval experience, was lost following dengue virus infection.…”

Section: The Behavioural Frameworkmentioning

confidence: 99%

Modulation of odour-guided behaviour in mosquitoes

Hill

2021

Cell Tissue Res

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Mosquitoes are emerging as model systems with which to study innate behaviours through neuroethology and functional genomics. Decades of work on these disease vectors have provided a solid behavioural framework describing the distinct repertoire of predominantly odour-mediated behaviours of female mosquitoes, and their dependence on life stage (intrinsic factors) and environmental cues (extrinsic factors). The purpose of this review is to provide an overview of how intrinsic factors, including adult maturation, age, nutritional status, and infection, affect the attraction to plants and feeding on plant fluids, host seeking, blood feeding, supplemental feeding behaviours, pre-oviposition behaviour, and oviposition in female mosquitoes. With the technological advancements in the recent two decades, we have gained a better understanding of which volatile organic compounds are used by mosquitoes to recognise and discriminate among various fitness-enhancing resources, and characterised their neural and molecular correlates. In this review, we present the state of the art of the peripheral olfactory system as described by the neural physiology, functional genomics, and genetics underlying the demonstrated changes in the behavioural repertoire in female mosquitoes. The review is meant as a summary introduction to the current conceptual thinking in the field.

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Dengue virus infection changes Aedes aegypti oviposition olfactory preferences

Cited by 25 publications

References 56 publications

Dengue infection modulates locomotion and host seeking in Aedes aegypti

Dengue infection modulates locomotion and host seeking in Aedes aegypti

Transcriptomic Analysis of Aedes aegypti Innate Immune System in Response to Ingestion of Chikungunya Virus

Modulation of odour-guided behaviour in mosquitoes

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