Dengue Virus and Platelets: From the Biology to the Clinic

Losada, Paula X.; DeLaura, Isabel; Narváez, Carlos F.

doi:10.1089/vim.2021.0135

Cited by 4 publications

(6 citation statements)

References 106 publications

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“…However, the replication machinery operates differently in the case of clathrin and receptor-mediated endocytosis, in which, after internalization of DENV, the virions remain trapped in endosomes and lysosomes and are not directly released in the cytoplasm. These processes need further research to be explained this in detail [ 19 ]. However, in general, at the ER, viral RNA is used as a template strand to translate into a polyprotein structure.…”

Section: Resultsmentioning

confidence: 99%

“…The replicative complex of flaviviruses consists of viral (NS5, NS3, and other small nonstructural proteins) and cellular subunits. Both the structure and functions of flavivirus RNA-dependent RNA polymerase are well known [ 11 , 19 , 20 ]. During this translation, DENV genes and proteins (such as NS5) with cap methylation characteristics and RNA polymerase activity play a vital role in the replication process.…”

Section: Resultsmentioning

confidence: 99%

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Tracing down the Updates on Dengue Virus—Molecular Biology, Antivirals, and Vaccine Strategies

Malik¹,

Ahsan

Mumtaz

et al. 2023

Vaccines

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Background: Nearly half of the world is at risk of developing dengue infection. Dengue virus is the causative agent behind this public healthcare concern. Millions of dengue cases are reported every year, leading to thousands of deaths. The scientific community is working to develop effective therapeutic strategies in the form of vaccines and antiviral drugs against dengue. Methods: In this review, a methodological approach has been used to gather data from the past five years to include the latest developments against the dengue virus. Results: Different therapeutics and antiviral targets against the dengue virus are at different stages of development, but none have been approved by the FDA. Moreover, various vaccination strategies have also been discussed, including attenuated virus vaccines, recombinant subunit vaccines, viral vector vaccines, DNA vaccines, nanotechnology, and plant-based vaccines, which are used to develop effective vaccines for the dengue virus. Many dengue vaccines pass the initial phases of evaluation, but only two vaccines have been approved for public use. DENGVAXIA is the only FDA-approved vaccine against all four stereotypes of the dengue virus, but it is licensed for use only in individuals 6–16 years of age with laboratory-confirmed previous dengue infection and living in endemic countries. Takeda is the second vaccine approved for use in the European Union, the United Kingdom, Brazil, Argentina, Indonesia, and Thailand. It produced sustained antibody responses against all four serotypes of dengue virus, regardless of previous exposure and dosing schedule. Other dengue vaccine candidates at different stages of development are TV-003/005, TDENV PIV, V180, and some DNA vaccines. Conclusion: There is a need to put more effort into developing effective vaccines and therapeutics for dengue, as already approved vaccines and therapeutics have limitations. DENGVAXIA is approved for use in children and teenagers who are 6–16 years of age and have confirmed dengue infection, while Takeda is approved for use in certain countries, and it has withdrawn its application for FDA approval.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Tracing down the Updates on Dengue Virus—Molecular Biology, Antivirals, and Vaccine Strategies

Malik¹,

Ahsan

Mumtaz

et al. 2023

Vaccines

View full text Add to dashboard Cite

show abstract

“…Quanto aos sinais de alarme, a queda abrupta de plaquetas destacou-se, acometendo 76,3% dos pacientes, o que corrobora a associação da dengue com a plaquetopenia, a qual já é conhecida como um biomarcador de gravidade [25][26][27]. Contudo, sangramento de mucosas e outras hemorragias tiveram baixa frequência nos casos de óbitos analisados.…”

Section: Discussionunclassified

Caracterização de pacientes hospitalizados com dengue que evoluíram para óbito em um complexo hospitalar de referência

Filho,

Lima,

Mendes

et al. 2024

BJCMR

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Caracterizar casos de dengue que resultaram em óbito no complexo hospitalar da Fundação Faculdade Regional de Medicina de São José do Rio Preto, entre 2018 e 2022. Estudo descritivo e retrospectivo de óbitos por dengue, a partir da análise de notificações. Foram identificados 59 óbitos, com maior ocorrência em homens (55,9%) com faixa etária entre 70 e 79 anos (22%). No aspecto clínico, apenas febre e mialgia estiveram presentes em mais de 50% dos casos. Na dengue com sinais de alarme, a queda abrupta de plaquetas foi observada em 76,3% dos pacientes, enquanto na dengue grave, taquicardia (59,3%) e alteração da consciência (54,2%) foram mais frequentes. Constatou-se um perfil laboratorial caracterizado por anemia, leucocitose relativa, plaquetopenia, Proteína-C reativa elevada, disfunção renal e hepática. O perfil clínico-laboratorial dos pacientes reforça as manifestações típicas de gravidade da dengue e devem ser monitoradas na evolução dos casos.

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“…Dengue fever is a mosquito-borne viral disease mainly found in tropical and subtropical regions. Infection of dengue virus in patients will cause capillary leakage, bleeding, and organ compromise, and in severe cases, it can lead to shock or even death ( 77 ). Platelets are crucial in the pathogenesis of DENV, as the infection is often accompanied by thrombocytopenia ( 78 ).…”

Section: Cargoes Uptake By Platelets Endocytosismentioning

confidence: 99%

“…Platelets are crucial in the pathogenesis of DENV, as the infection is often accompanied by thrombocytopenia ( 78 ). Therefore absolute platelet count is used as lab indication to examine the disease progression of DENV ( 77 ). Researches have established that dengue induces platelet activation, mitochondrial dysfunction and apoptosis ( 79 , 80 ).…”

Section: Cargoes Uptake By Platelets Endocytosismentioning

confidence: 99%

New insights of platelet endocytosis and its implication for platelet function

Zhou,

Dong,

Wang

et al. 2024

Front. Cardiovasc. Med.

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Endocytosis constitutes a cellular process in which cells selectively encapsulate surface substances into endocytic vesicles, also known as endosomes, thereby modulating their interaction with the environment. Platelets, as pivotal hematologic elements, play a crucial role not only in regulating coagulation and thrombus formation but also in facilitating tumor invasion and metastasis. Functioning as critical components in the circulatory system, platelets can internalize various endosomal compartments, such as surface receptors, extracellular proteins, small molecules, and pathogens, from the extracellular environment through diverse endocytic pathways, including pinocytosis, phagocytosis, and receptor-mediated endocytosis. We summarize recent advancements in platelet endocytosis, encompassing the catalog of cargoes, regulatory mechanisms, and internal trafficking routes. Furthermore, we describe the influence of endocytosis on platelet regulatory functions and related physiological and pathological processes, aiming to offer foundational insights for future research into platelet endocytosis.

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Dengue Virus and Platelets: From the Biology to the Clinic

Cited by 4 publications

References 106 publications

Tracing down the Updates on Dengue Virus—Molecular Biology, Antivirals, and Vaccine Strategies

Tracing down the Updates on Dengue Virus—Molecular Biology, Antivirals, and Vaccine Strategies

Caracterização de pacientes hospitalizados com dengue que evoluíram para óbito em um complexo hospitalar de referência

New insights of platelet endocytosis and its implication for platelet function

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