Dengue vaccine: priorities and progress

Guzmán, María G.; Muné, Mayra; Kourı́, Gustavo

doi:10.1586/14789072.2.6.895

Cited by 16 publications

(14 citation statements)

References 151 publications

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“…Since there is no vaccine to protect against dengue, the only method for controlling or preventing dengue virus transmission is to combat the vector mosquitoes (Guzmán and Kouri 2002, Guzmán et al 2004, WHO 2009). Setting ovitraps serves as a method of vector detection (Kitron et al 1989, Chadee and Corbet 1990, Chadee et al 1995, Reiter et al 1995.…”

Section: Introductionmentioning

confidence: 99%

Prevention of Dengue Outbreaks Through Aedes aegypti Oviposition Activity Forecasting Method

Estallo

Ludueña-Almeida

Visintin

et al. 2011

Vector-Borne and Zoonotic Diseases

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Dengue has affected the north provinces of Argentina, mainly Salta province. The 2009 outbreak, with 5 deaths and >27,000 infected, was the most important, and the first to extend into the central area of the country. This article includes research on seasonal Aedes aegypti abundance variation in Orán City (Salta province), and determination of the date of mosquito population increase and an estimation of the date of maximum rate of increase as well as the intrinsic rate of natural increase (r), to detect the optimal time to apply vector control measures. Between September 2005 and March 2007, ovitraps were randomly distributed in the city to collect Ae. aegypti eggs. The variation observed in the number of collected eggs was described by fitting a third-degree polynomial by the least square method, allowing to determine the time when population increase began (week 1), after the temperate and dry season. Eggs were collected throughout the year, with the highest variation in abundance during the warm and rainy season, and the maximum value registered in February 2007. The rate of increase of the number of eggs laid per week peaked between weeks 9 and 10 after the beginning of the population increase (week 1). Week 1 depends on temperature, it occurs after getting over the thermal threshold and the needed accumulation of 160 degree-day is reached. Consequently, week 1 changes depending on temperature. Peak abundance of eggs during 2005-2006 was recorded on week 15 (after week 1); during 2006-2007, the peak was observed on week 22. Estimation of the intrinsic rate of natural increase (r) of Ae. aegypti is useful not only to determine optimal time to apply vector control measures with better cost-benefit, but also to add an insecticide control strategy against the vector to diminish the possibility of resistance.

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Section: Introductionmentioning

confidence: 99%

Prevention of Dengue Outbreaks Through Aedes aegypti Oviposition Activity Forecasting Method

Estallo

Ludueña-Almeida

Visintin

et al. 2011

Vector-Borne and Zoonotic Diseases

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“…While a vaccine is currently under development, without immediate prospects for success, vector control remains the only viable method to prevent dengue transmission [9], [10], [11], [12]. Improved knowledge regarding egg-laying behavior is relevant because it underpins the primary surveillance method, i.e., ovitraping [13], [14].…”

Section: Introductionmentioning

confidence: 99%

Indoor-Breeding of Aedes albopictus in Northern Peninsular Malaysia and Its Potential Epidemiological Implications

et al. 2010

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BackgroundThe mosquito Ae. albopictus is usually adapted to the peri-domestic environment and typically breeds outdoors. However, we observed its larvae in most containers within homes in northern peninsular Malaysia. To anticipate the epidemiological implications of this indoor-breeding, we assessed some fitness traits affecting vectorial capacity during colonization process. Specifically, we examined whether Ae. albopictus exhibits increased survival, gonotrophic activity and fecundity due to the potential increase in blood feeding opportunities.Methodology/Principal FindingsIn a series of experiments involving outdoors and indoors breeding populations, we found that Ae. albopictus lives longer in the indoor environment. We also observed increased nighttime biting activity and lifetime fecundity in indoor/domestic adapted females, although they were similar to recently colonized females in body size.Conclusion/SignificanceTaken together these data suggest that accommodation of Ae. albopictus to indoor/domestic environment may increase its lifespan, blood feeding success, nuisance and thus vectorial capacity (both in terms of increased vector-host contacts and vector population density). These changes in the breeding behavior of Ae. albopictus, a potential vector of several human pathogens including dengue viruses, require special attention.

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“…albopictus ranks also among the world's worst invasive species (http://www.issg.org/database). Currently, in the absence of a vaccine against dengue (Deen 2004;Guzmán et al 2004), vector control continues to be the only feasible option for the control of dengue transmission (McCall & Kittayapong 2007). This has made dengue to become one of the most insecticides targeted vector borne diseases (van den Berg et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Purification and expression of glutathione S-transferase from a Malaysian population of Aedes albopictus (Diptera: Culicidae)

et al. 2014

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Glutathione S-transferase (GST) from the 4 th instar larvae of the dengue vector Aedes albopictus was purified by glutathione-agarose affinity chromatography and characterised using SDS-PAGE. The expression of the purified enzyme in the life stages and insecticide treated populations of Ae. albopictus as well as its cross-reactivity with larval GST of two dipteran species Aedes aegypti and Batrocera papayae were observed using western blotting. The purified GST had a specific activity of 196.0 ± 11 µmol/min/mg with a purification fold and yield of 28 and 69%, respectively. The SDS-PAGE analysis of the purified GST depicted a single band size of 23 kDa. The GST was expressed in all the larval and adult stages of Ae. albopictus with the exception of the pupal stage. However, the expression level in the adult stage was visibly reduced as compared to the larval stages. Western blotting analysis showed no cross-reactivity with the GST of Ae. aegypti (4 th instar) and B. papayae (3 rd instar) larvae. The expression of this enzyme was not inducible by exposure to the insecticides dichlorodiphenyltrichloroethane (1.25 mg/L) and malathion (0.3125 mg/L).

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Dengue vaccine: priorities and progress

Cited by 16 publications

References 151 publications

Prevention of Dengue Outbreaks Through Aedes aegypti Oviposition Activity Forecasting Method

Prevention of Dengue Outbreaks Through Aedes aegypti Oviposition Activity Forecasting Method

Indoor-Breeding of Aedes albopictus in Northern Peninsular Malaysia and Its Potential Epidemiological Implications

Purification and expression of glutathione S-transferase from a Malaysian population of Aedes albopictus (Diptera: Culicidae)

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