Dengue: The Continual Re-Emergence of a Centuries-Old Disease

Morens, David M.; Folkers, Gregory K.; Fauci, Anthony S.

doi:10.1007/s10393-013-0825-7

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…In addition to globalization, climate change is affecting the temperature pattern in some areas making them more vulnerable to mosquito-borne diseases like dengue fever (Semenza et al 2019;Lillepold et al 2019). Mosquito-borne illnesses have plagued humanity throughout history, with some of the most devastating human epidemics, such as malaria and dengue wreaking havoc on the human population in the form of death and diseases (Morens, et al 2013;Salgueiro et al 2019). New and far more dreadful mosquito-borne viruses, such as the zika virus and yellow fever, have begun to in ict mayhem on human populations in many regions around the globe (Baud et al 2017; Douam and Ploss 2018; Ahmed et al…”

Section: Introductionmentioning

confidence: 99%

A 90-day subchronic oral toxicity assessment of cry11Ba protein expressed in genetically modified Chlamydomonas reinhardtii by using Han Wistar rats.

Khan

Ahmed

et al. 2022

Preprint

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Mosquito-borne diseases are a persistent risk to humanity all over the world. A genetically modified algae (Chlamydomonas reinhardtii) producing mosquito larvicidal cry11Ba protein was constructed in Biopharmaceutical Laboratories of CEMB, University of Punjab, Pakistan. The current study aims at the biosafety assessment of this transgenic algae in Han Wistar rats for a 90-days trial period. Thirty male Han Wistar rats were used in the experiment, divided into three groups which were given transgenic algae mixed water (at 1x105cell mL− 1 concentration), non-transgenic algae mixed water (at 1x105cell mL− 1 concentration), and simple water without algae respectively for 90-days. Han Wistar rats were regularly clinically observed for any mortality, allergenicity, moribundity, water consumption, feed consumption, body weight, hematology, serum chemistry (LFT, RFT, serum electrolytes), urine analysis, molecular analysis, necropsy analysis (organs morphology, organ weight, and histopathology of vital organs) and found no substantial difference among any of the groups. In conclusion, there was no adverse effect found on the overall health of male Han Wistar rat feeding on transgenic algae (Chlamydomonas reinhardtii) producing the cry11Ba protein.

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Section: Introductionmentioning

confidence: 99%

A 90-day subchronic oral toxicity assessment of cry11Ba protein expressed in genetically modified Chlamydomonas reinhardtii by using Han Wistar rats.

Khan

Ahmed

et al. 2022

Preprint

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“…Later, and in the same context, Focks et al [11,12] closed this loophole by using dynamic table models to illustrate the evolution of these populations. Because of its continued re-emergence [13], the study of the dengue's spread has not stopped at this stage, and even it remains until now an active research subject that inspires several recent papers, see [14,15,16,17] and the references given there. For example, in [14] the authors constructed a deterministic dengue's propagation model and parametrized it by employing real data from the 2017 dengue outbreak in Pakistan.…”

Section: Introduction and Model Formulationmentioning

confidence: 99%

A novel mathematical analysis and threshold reinforcement of a stochastic dengue epidemic model with Lévy jumps

Kiouach¹,

El-idrissi²,

Sabbar³

2021

Preprint

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The rampant phenomenon of overpopulation and the remarkable increase of human movements over the last decade have caused an aggressive re-emergence of dengue fever, which made it the subject of several research fields. In this regard, mathematical modeling, and notably through compartmental systems, is considered as an eminent tool to obtain a clear overview of this disease's prevalence behavior. In reality, and like all epidemics, the dengue spread phenomenon is often subject to some randomness due to the different natural environment fluctuations. For this reason, a mathematical formulation that considers suitably as much as possible the external stochasticity is indeed required. By this token, we strive in this work to present and analyze a generalized stochastic dengue model that incorporates both slight and huge environmental perturbations. More precisely, our proposed model is represented under the form of an Itô-Lévy stochastic differential equations system that we demonstrate its mathematical wellposedness and biological significance. Based on some novel analytical techniques, we prove, and under appropriate hypothetical frameworks, of course, two important asymptotic properties, namely: extinction and persistence in the mean. The theoretical findings show that the dynamics of our disturbed dengue model are mainly determined by the parameters that are narrowly related to the small perturbations' intensities and the jumps magnitudes. In the end, we give certain numerical illustrative examples to support our theoretical findings and to highlight the effect of the adopted mathematical techniques on the results.

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“…mosquito vectors. Currently, it is estimated that at least 2.5 billion people live in the tropical and contiguous temperate areas where dengue occurs, and even more people will be in harm's way as the range of DENV vectors expands (Gupta et al, 2012;Morens, 1994;Morens and Fauci, 2008;Morens et al, 2013).…”

mentioning

confidence: 99%

Dengue vaccine clinical trials in India — An opportunity to inform the global response to a re-emerging disease challenge

Fauci

Erbelding²,

Whitehead³

et al. 2019

International Journal of Infectious Diseases

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Dengue: The Continual Re-Emergence of a Centuries-Old Disease

Cited by 8 publications

References 5 publications

A 90-day subchronic oral toxicity assessment of cry11Ba protein expressed in genetically modified Chlamydomonas reinhardtii by using Han Wistar rats.

A 90-day subchronic oral toxicity assessment of cry11Ba protein expressed in genetically modified Chlamydomonas reinhardtii by using Han Wistar rats.

A novel mathematical analysis and threshold reinforcement of a stochastic dengue epidemic model with Lévy jumps

Dengue vaccine clinical trials in India — An opportunity to inform the global response to a re-emerging disease challenge

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