Dengue outbreaks in South Asia amid Covid-19: Epidemiology, transmission, and mitigation strategies

Manna, Subhanwita; Satapathy, Prakasini; Bora, Ishani; Padhi, Bijaya Kumar

doi:10.3389/fpubh.2022.1060043

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…Despite the efforts of dengue control programs, the burden of dengue still becomes a problem for several tropical countries, including Indonesia. Moreover, the COVID-19 pandemic that affected people worldwide has masked the increase i dengue incidence and poses new challenges in dengue control, especially in dengue-endemic regions with highly transmitted COVID-19 infections and limited resources [ 4 , 5 , 6 ]. Several factors can be related to dengue outbreaks, including demography, environment, and social and ecological factors [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Way to Develop Dengue Virus Detection in Aedes Larvae as an Alternative for Dengue Active Surveillance: A Literature Review

Rachmawati,

Ekawardhani,

Fauziah

et al. 2024

TropicalMed

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The burden of dengue has emerged as a serious public health issue due to its impact on morbidity, mortality, and economic burden. Existing surveillance systems are inadequate to provide the necessary data for the prompt and efficient control of dengue. Passive surveillance of dengue cases may lead to underreporting and delayed mitigation responses. Improved dengue control program requires sensitive and proactive methods for early detection of dengue. We collected and reviewed existing research articles worldwide on detecting dengue virus in Aedes species larvae. Searches were conducted in PUBMED and Google Scholar, including all the studies published in English and Bahasa Indonesia. Twenty-nine studies were included in this review in terms of assay used, positivity rate, and dengue serotype detected. The presence of dengue virus in immature mosquitoes was mostly detected using reverse transcription PCR (RT-PCR) in pooled larvae. In one study, dengue virus was detected in larvae from laboratory-infected mosquitoes using enzyme-linked immunosorbent assay (ELISA). The positivity rate of dengue virus detection ranged from 0 to 50% in field-caught larvae. Although various methods can detect the dengue virus, further research encourages the use of low-cost and less laborious methods for active surveillance of dengue in larvae.

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Section: Introductionmentioning

confidence: 99%

Potential Way to Develop Dengue Virus Detection in Aedes Larvae as an Alternative for Dengue Active Surveillance: A Literature Review

Rachmawati,

Ekawardhani,

Fauziah

et al. 2024

TropicalMed

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“…Over the past three centuries, isolated epidemics have occurred on several continents, such as the Americas, Asia, and Europe, and in several countries, such as Australia, with an exacerbation in Southeast Asian countries. There has been an increase in the intensity of the disease in the form of epidemics or endemics, which have caused thousands of deaths, predominantly in children [ 10 , 11 , 12 ]. One of the factors associated with this characteristic is the fact that dengue is a disease that manifests itself mainly in periods of heavy rainfall and, depending on the social determinants, can cause serious harm to the population; thus, public health actions become essential for its control [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil

et al. 2023

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Arboviruses constitute the largest known group of viruses. These viruses are the etiological agents of pathologies known as arboviruses, with dengue being one of the most prevalent. Dengue has resulted in important socioeconomic burdens placed on different countries around the world, including those in Latin America, especially Brazil. Thus, this work intends to carry out a narrative-based review of the literature, conducted using a study of the secondary data developed through a survey of scientific literature databases, and to present the situation of dengue, particularly its distribution in these localities. Our findings from the literature demonstrate the difficulties that managers face in controlling the spread of and planning a response against dengue, pointing to the high cost of the disease for public coffers, rendering the resources that are already limited even scarcer. This can be associated with the different factors that affect the spread of the disease, including ecological, environmental, and social factors. Thus, in order to combat the disease, it is expected that targeted and properly coordinated public policies need to be adopted not only in specific localities, but also globally.

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“…In 2021, prevalence of dengue has increased over three times in India (44,585 versus 193,245 cases), 19 times in Bangladesh (1,405 versus 28,429 cases), 2 times in Singapore (5,000 versus 11,000), over 1.8 times in Malaysia (87,000 versus 120,000 cases), and more than seven times (6,016 vs. 52,894 instances) in Pakistan. Taiwan, Sri Lanka, Mexico, and the Philippines have also reported notable increase, while Brazil documented a surge in severe cases and fatalities predominantly impacting younger population under 20 years of age during the period of 2021-2022 [ [1], [2], [3], [4]]. DENV circulates as four serotypes (DENV 1-4) each containing multiple distinct genotypes.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infectionin-vitroandin-vivo

Jakhar,

Sonar,

Singh

et al. 2023

Preprint

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Dengue disease is highly prevalent in tropical and subtropical regions worldwide. However, its pathogenesis is still incompletely understood, particularly in comparison to other endemic viruses. Antibody-dependent enhancement (ADE) is a well-known phenomenon for dengue viruses. Given the recent surge in dengue cases and potential cross-reactivity with SARS-CoV-2 antibodies, this study explores the impact of anti-SARS-CoV-2 antibodies on DENV-2 infection.The study assessed the cross-reactivity of SARS-CoV-2 antibodies with the DENV-2 Virus. Human convalescent plasma samples collected during different waves of COVID-19 and monoclonal and polyclonal antibodies raised against SARS-CoV-2 were examined for their potential to cause ADE of DENV-2 infection using cell-based assays. The study found that anti-SARS-CoV-2 antibodies acquired from natural infection in humans or through experimental immunization in animals were cross-reactive with DENV-2 and had the potential to enhance DENV-2 infection in K562 and U937 cells. In-silico and in-vitro studies indicated a strong interaction between SARS-CoV-2 antibodies and DENV-2 E-protein, providing a molecular basis for these findings. This study is the first to demonstrate that anti-SARS-CoV-2 antibodies can cross-react with DENV-2 and can enhance its infection through ADE. These findings have implications for SARS-CoV-2 vaccine development and deployment strategies in regions where dengue is endemic.SummaryAntibodies against SARS-CoV-2 (RBD and Spike) showed significant cross reactivity with DENV-2 (E protein). Also, anti-SARS-CoV-2-commercial antibodies, immunised animal sera and 46 human convalescent plasma samples (from different waves of pandemic) demonstrated antibody-dependent enhancement (ADE) of DENV-2 infection.

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Dengue outbreaks in South Asia amid Covid-19: Epidemiology, transmission, and mitigation strategies

Cited by 4 publications

References 11 publications

Potential Way to Develop Dengue Virus Detection in Aedes Larvae as an Alternative for Dengue Active Surveillance: A Literature Review

Potential Way to Develop Dengue Virus Detection in Aedes Larvae as an Alternative for Dengue Active Surveillance: A Literature Review

Dengue as a Disease Threatening Global Health: A Narrative Review Focusing on Latin America and Brazil

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infectionin-vitroandin-vivo

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