Dengue Outbreak in Key West, Florida, USA, 2009

Radke, Elizabeth G.; Gregory, Christopher J.; Kintziger, Kristina W.; Sauber-Schatz, Erin K.; Hunsperger, Elizabeth; Gallagher, Glen R.; Barber, Jean M.; Biggerstaff, Brad J.; Stanek, Danielle; Tomashek, Kay M.; Blackmore, Carina

doi:10.3201/eid1801.110130

Cited by 142 publications

(120 citation statements)

References 9 publications

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“…All patients aged between 18-and 75-years-old with fever > 37.5 °C for less than 72 h were invited to participate in the study. Anti-dengue IgM and IgG enzyme-linked immunosorbent assay kits were employed to confirm dengue infection (Radke et al, 2012). We obtained 168 serum samples during the dengue outbreak in Guangzhou in 2014.…”

Section: Sample Collectionmentioning

confidence: 99%

Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

Pan

et al. 2017

Virol. Sin.

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The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic inGuangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope (E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype I strains, including 8 genotype I and 9 genotype V strains. Additionally, 6 genotype I strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype I strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype V strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou.

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Section: Sample Collectionmentioning

confidence: 99%

Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

Pan

et al. 2017

Virol. Sin.

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“…During 2009-2010, the Florida Department of Health reported 93 autochthonous cases of dengue fever in Key West, FL, the first autochthonous dengue fever cases since 1934. 5,6 Since November 2010, no cases of dengue have been reported from Key West; however, autochthonous cases have been reported annually since 2010 in other counties in Florida underscoring risk of continued local transmission in parts of Florida. 7 In response to the potential threat of further dengue transmission in the Keys and other regions of Florida, during the fall of 2012, we conducted a survey with decision makers, ranging from local to federal levels, who were involved with the response to the outbreak in Key West.…”

Section: Introductionmentioning

confidence: 99%

Post Outbreak Review: Dengue Preparedness and Response in Key West, Florida

Hayden

Cavanaugh

Tittel

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. Dengue is the most prevalent mosquito-borne viral infection. Recent outbreaks in the southern United States illustrate the risk of reemergence. The first autochthonous cases since 1934 in Key West, FL, occurred in 2009-2010. We conducted a survey in 2012 with decision makers instrumental to the control of the outbreak to 1) determine their awareness of the multiple strategies used to control the outbreak and 2) assess their perceptions of the relative effectiveness of these strategies. An online survey was delivered to a predefined list of decision makers from multiple sectors to better understand dengue preparedness and response. Thirty-six out of 45 surveys were returned for an 80% response rate. Results indicate the need to focus prevention strategies on educational campaigns designed to increase population awareness of transmission risk. Respondents remain concerned about future dengue transmission risk in Key West and lack of resources to respond.

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“…In addition, the detection of IgM and IgG antibodies is also considered the main technique for the laboratory diagnosis, to know the immune response model and to differentiate between primary and secondary infections for dengue [7,20].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Ades albopictus also called, "Asian Tiger" mosquito, is an epidemiologically important vector in tropical and subtropical countries of South East Asia for the transmission of many viral pathogens including dengue virus. [7].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Profile and Laboratory Characteristics of Dengue Virus Infection during 2011 Outbreak in Rawalpindi, Islamabad Pakistan

Suleman¹

2016

JHVRV

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A total of 215 serum samples of clinically suspected dengue patients who presented to the tertiary care hospitals over a period of July-November 2011 were analyzed for the detection of dengue NS1 antigen, dengue IgM and IgG antibodies and 180 (83.7%) samples were found positive by one or more than one testing parameters. Of the 180 samples, 98 (54.4%) were positive to NS1, 168 (93.3%) were positive to IgM and 93 (51.6%) cases were positive to IgG only. Similarly, 93 (51.6%) were positive to both NS1 and IgM, 48 (26.6%) to NS1 and IgG, and 83 (46.1%) were positive to both IgM and IgG and 48(26%) were positive for NS1, IgM and IgG.A randomly selected subset of 50 serology positive samples were tested by, one step TaqMan real time fourplex RT-PCR assay. A total of 35/50 (70%) samples were found positive by PCR. Positive rates of dengue serotypes were 15/35 (42.8%), 11/35 (31.4%) and 9/35 (25.7%) for DENV-1, DENV-2 and DENV-3 respectively. No DENV-4 serotype was detected.

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Dengue Outbreak in Key West, Florida, USA, 2009

Cited by 142 publications

References 9 publications

Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China

Post Outbreak Review: Dengue Preparedness and Response in Key West, Florida

Epidemiological Profile and Laboratory Characteristics of Dengue Virus Infection during 2011 Outbreak in Rawalpindi, Islamabad Pakistan

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